Systemic Lupus Erythematosus with Takayasu’s Arteritis - A Rare Co-existance

Biswas, Sarmistha; Hafiz, SM; Basu, Kamalesh Chandra; Khan, Ahm Ejrarul Alam; Sarker, Mouri; Ahmed, Tanveer

doi:10.3329/jom.v22i2.56706

Cited by 1 publication

(3 citation statements)

References 7 publications

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“…Hence, it has been hypothesised that T cell-mediated immunity may play a role in the coexistence of Takayasu arteritis and SLE (15,16). Notably, the coexistence of TA and SLE predominantly affects females (10,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). This is consistent with the nding of marked female preponderance seen in isolated cases of Takayasu's arteritis and SLE and is thought to be due to endocrinological variables (12).…”

Section: Discussionsupporting

confidence: 67%

“…(i) Unequal pulses in the upper extremities with ANA, anti-dsDNA and had anti-ribonucleoprotein antibodies (13) (ii) Increased upper limb BP , lower abdominal bruit, butter y rash, and photosensitive dermatitis with ANA and LE cell antibodies (16) (iii) Unequal pulses in both upper limbs and diarrhea with a high ANA titer as well as a positive lupus band test on skin (17) (iv) Severe chest pain along with a wide mediastinum on CXR (18) Most patients with a combination of diseases exhibit symptom improvement, and some even achieve complete recovery; however, a few patients experience severe outcomes, such as unresponsiveness to aggressive treatment or renal issues (10,12,15,16,(18)(19)(20)(21)(22). Renal involvement in such patients can include ESRD or persistent proteinuria and indicates a worse prognosis (16,20).…”

Section: Discussionmentioning

confidence: 99%

“…The management of patients with both TA and SLE involves a combination of glucocorticoids and nonglucocorticoid immunosuppressive agents along with speci c treatments tailored to individual patient needs (10,(12)(13)(14)(15)(16)(18)(19)(20)(21)(22). Intravenous immunoglobulins have also been used (19).…”

Section: Discussionmentioning

confidence: 99%

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Unusual Coexistence of Takayasu's Arteritis and Systemic Lupus Erythematosus in a Woman: A Case Report

Jindal,

Suresh,

Kamaraj

et al. 2024

Preprint

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Takayasu’s arteritis (TA) and systemic lupus erythematosus (SLE) are distinct autoimmune disorders with similar age and gender predisposition. However, their coexistence is exceedingly rare, and presents unique diagnostic and therapeutic challenges. Here, we report the case of a 44-year-old female with nodular episcleritis, breathlessness, and palpitations who was ultimately diagnosed with both TA and SLE. The presence of a range of antibodies in various cases underscores the heterogeneity of the disease presentation and the need for comprehensive testing. While many patients with this dual diagnosis experience symptom improvement and complete recovery, some face severe outcomes. In our case, aortic root replacement surgery was planned because of severe aortic regurgitation; however, the patient's condition deteriorated, resulting in death. This case underscores the need for clinicians to recognise and thoroughly evaluate patients with overlapping symptoms of TA and SLE. Although challenging, the coexistence of these autoimmune diseases provides valuable insights into the complexities of autoimmune conditions. Further research and collaboration are essential to advance our understanding and to improve patient outcomes in these complex clinical scenarios.

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