Systemic manifestations of Takayasu arteritis: The expanding spectrum

Takayasu’s arteritis

“…Erythema nodosum and pyoderma gangrenosum are the most common skin manifestations of Takayasu's arteritis [3]. Gastrointestinal symptoms are rare, although they were reported in 1% to 19% of patients in a large series [1•].…”

“…Compared with healthy Japanese controls, 50% of Japanese patients with Takayasu's arteritis were shown to have Bw52 and Dw12 antigens [2,3]. It has been suggested that Bw52 indicates a poor prognosis when it is found in association with aortic regurgitation and left ventricular perfusion abnormalities (52% and 76%, respectively).…”

Possible activation of an intramyocardial inflammatory process (Staphylococcus aureus) after treatment with infliximab in a boy with Crohn disease

“…Patients with Crohn disease do carry additional risks as they are more susceptible to bacterial infections possibly due to their disturbed mucosal barrier and to concomitant immunosuppressive therapy [6,18]. In addition, Crohn disease itself may lead to vasculitic changes of the aorta [5,10,15], which might have further favoured the development of the intramyocardial abscess in our patient. The size of the abscess suggested its persistence for several weeks, however, it gained only destructive activity shortly after infliximab was given.…”

The Efficacy of Tocilizumab for Takayasu Arteritis: Review of the Literatures

“…Elevated CRP and/or ESR are not routine findings but may reflect the degree of inflammation and also may guide the therapy. At the onset of the disease fever, weight loss, fatigue, malaise, myalgia and arthralgia are frequent as a result of systemic inflammation [14]- [16]. Arterial inflammation may lead to headache, thoracic pain, and carotidynia.…”

“…Arterial inflammation may lead to headache, thoracic pain, and carotidynia. Furthermore, the clinical symptoms associated to arterial compromise (abdominal and cardiac angina, heart failure, dizziness, symptoms from an enlarging aneurysm, dissection, transient ischemic attack, or stroke) may also occur frequently [16].…”