Systemic methotrexate: An effective alternative to surgery for management of unruptured ectopic pregnancy

Talwar, Pankaj; Kharb, Simmi; Naredi, Nikita; Duggal, BS; Jose, Tony

doi:10.1016/j.mjafi.2012.08.032

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…today, advanced laboratory and imaging methods allow for early diagnosis and medical treatment with mtX in the cases with eP 8 . mtX is successfully used for the treatment of unruptured ePs as an effective, safe and noninvasive method with minimal or no side effects 9 . in the treatment of eP, mtX use has been reported to have no unfavorable effect on the subsequent ovarian reserve, ovarian responsiveness, or success of in vitro fertilization [10][11][12] .…”

Section: Discussionmentioning

confidence: 99%

Fertility Outcomes after Medical and Surgical Management of Tubal Ectopic Pregnancy

Düz

2021

ACC

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and gynecology, division of reproductive endocrinology and infertility, inonu university Faculty of medicine, malatya, turkey SummAry -The objective was to investigate whether the method of treatment (surgical or medical) affects achieving a new pregnancy, as well as the time to and prognosis of the new pregnancy, in women with ectopic pregnancy (eP). information on patients treated in our hospital between 2013 and 2014 for eP was retrieved from the computerized patient records. data on whether these patients achieved pregnancy after eP treatment, time from treatment to new pregnancy, and prognosis of pregnancy were collected by phone interviews. A total of 101 women were analyzed. in addition to descriptive analysis, the χ 2 -test and Kruskal Wallis test were used to compare the groups. A new pregnancy was present in 84 (83.2%) of the women after eP treatment. There was no significant difference among the women having undergone medical treatment (methotrexate), surgical treatment, medical treatment followed by surgical treatment, or observational management approach in terms of achieving a new pregnancy after treatment and time to and prognosis of the new pregnancy. The study could not determine which treatment method would be superior in women with eP and in planning future pregnancy, but concluded that close clinical and laboratory monitoring is appropriate before deciding on aggressive interventions.

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Section: Discussionmentioning

confidence: 99%

Fertility Outcomes after Medical and Surgical Management of Tubal Ectopic Pregnancy

Düz

2021

ACC

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“…This was probably because most of these patients were undergoing IVF and were on close follow up. 6 In another study by Vaswani, 54.6% patients had primary surgery and in the study by Bonin, 57.2% patients were treated with primary surgical therapy. 7,8 These figures are comparable to our study.…”

Section: Discussionmentioning

confidence: 94%

Success of medical management of tubal ectopic pregnancy with Methotrexate in a tertiary hospital in North India

Juneja

Jain

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Unruptured ectopic pregnancy can be managed with surgery as well as systemic methotrexate. We aimed to study efficacy of medical management and factors affecting success in strictly selected patients.Methods: It was a three-year prospective observational study. 171 patients with ectopic pregnancy were screened and those fulfilling the strict study criteria were given systemic methotrexate. The single dose regimen was followed. Patients were observed for side effects and signs of rupture. Serial measurement of HCG levels was done to determine success or failure. Various factors were studied which had potential bearing on results.Results: Thirty-one patients received methotrexate. We had an overall success rate of 93%. Two of the participants had surgery due to failure. No major side effects were observed.Conclusions: Carefully selected patients of unruptured ectopic pregnancy can be safely and successfully treated with systemic methotrexate.

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“…Найчастіше при лікуванні ПВ метотрексатом зустрічаються такі побічні ефекти, як стоматит, гастрит і ентеропатія (діарея), а також транзиторне підвищення рівня печінкових трансаміназ, що свідчить про ураження печінки. Так, при чотирикратному внутрішньом'язовому введенні метотрексату в дозі 1 мг/кг подібні ускладнення зареєстровані у 50% хворих [1,2,9].…”

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Some aspects of drug treatment of ectopic pregnancy

Бойчук¹,

Якимчук²,

Коптюх³

et al. 2019

Reproductive Endocrinology

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Systemic methotrexate: An effective alternative to surgery for management of unruptured ectopic pregnancy

Abstract: Methotrexate therapy is a safe and effective alternative for the management of unruptured ectopic pregnancies with minimal or no side-effects and associated advantage of avoiding invasive surgery.

Cited by 11 publications

References 9 publications

Fertility Outcomes after Medical and Surgical Management of Tubal Ectopic Pregnancy

Fertility Outcomes after Medical and Surgical Management of Tubal Ectopic Pregnancy

Success of medical management of tubal ectopic pregnancy with Methotrexate in a tertiary hospital in North India

Some aspects of drug treatment of ectopic pregnancy

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