Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates

Kinoshita, Mari; Stempel, Katarzyna S; Nascimento, Israel Júnior Borges do; Bruschettini, Matteo

doi:10.1002/14651858.cd014876

Cited by 12 publications

(2 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The opioids morphine, fentanyl, and remifentanil are the most frequently employed analgesic agents in neonates [4,8]. Typically, they are used for procedural or post-operative pain, either as monotherapy or in combination with other drugs [88,89]. Overall, the use of specific pain scales in neonates revealed that opioids reduce procedural pain.…”

Section: Opioidsmentioning

confidence: 99%

Antibiotic Analgesic-Sedative and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review

Kontou,

Agakidou,

Chatziioannidis

et al. 2024

Preprint

View full text Add to dashboard Cite

Several studies have shown that antibiotics, analgesic – sedative, and antiseizure medications are among the most commonly used medications in preterm and sick neonates. These infants are at high risk of developing nosocomial infections, central nervous system complications, and are exposed to numerous painful/stressful procedures. These severe, potentially life-threatening complications may have serious short- and long-term consequences and should be prevented and/or promptly treated. Previous studies and reviews have revealed significant variability in medications used in neonatal intensive care units (NICUs) worldwide, especially concerning the indications and dosages of first-line medications. This variability indicates the lack of adequate studies regarding the effectiveness and safety of these medications in neonates, especially the preterm ones. Important obstacles contributing to inadequate studies in preterm infants include difficulties in obtaining parental consent, physicians’ unwillingness to recruit preterm infants, the lack of license for use in neonates, and other scientific and ethical concerns. This review is an update on the use of antimicrobials – antifungals, analgesics – sedatives, and antiseizure medications used in neonates, focusing on existing evidence or knowledge gaps regarding their pharmacokinetics, indications, safety, dosage regimen (dose, dosing interval, route of administration), and evidence-based guidelines for the optimal use in neonates.

show abstract

Section: Opioidsmentioning

confidence: 99%

Antibiotic Analgesic-Sedative and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review

Kontou,

Agakidou,

Chatziioannidis

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The management of neonatal pain is a critical health issue that is increasingly recognized by clinicians and researchers ( Hall and Anand, 2014 ; Carter and Brunkhorst, 2017 ; Shah and Siu, 2019 ; Carbajal, 2020 ; Mencía et al, 2022 ). However, the use of classical pain medications has some adverse effects in both the short and long term, thereby making their use controversial ( Bastaki et al, 2018 ; Shah and Siu, 201; Kinoshita et al, 2021 ). Therefore, identifying appropriate pain management methods for this vulnerable population is both ethically and clinically important.…”

Section: Introductionmentioning

confidence: 99%