Systemic Pharmacology of Adrenergic Activators and Inhibitors: Effects on the Respiratory System

Aviado, Domingo M.; Micozzi, M. S.

doi:10.1007/978-3-642-67584-3_1

Cited by 3 publications

(2 citation statements)

References 99 publications

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“…The pharmacological effects of sympathomimetic drugs upon the respiratory system have been studied extensively (Aviado & Micozzi, 1981) but while the action of a-or P-adrenoceptor agonists is reasonably characterized, the effects of dopamine on airway smooth muscle have received little attention compared with those on the cardiovascular system (Goldberg, 1972). However these effects could be important from a clinical as well as a pharmacological standpoint since patients receiving dopamine for haemodynamic reasons also may have airway disease and because dopamine is present in the lung (Eyre & Deline, 1971) and is released in anaphylaxis, at least in some animal species (Falck et al, 1964).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological analysis of the responsiveness of guinea‐pig lung parenchymal strip to dopamine

Cortijo

Esplugues

Morcillo

et al. 1984

British J Pharmacology

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1 Responses to dopamine were examined in the guinea-pig isolated lung parenchymal strip. 2 Complete cumulative concentration-response curves to dopamine exhibited a biphasic pattern with a small initial contraction at concentrations below 1o-5 M followed by a dose-dependent relaxation at higher concentrations. 3 Phentolamine (10-s M) completely abolished the contractile component and enhanced sensitivity and maximal relaxation to dopamine. In the presence of phentolamine, propranolol antagonized the dopamine-induced relaxation (pA2 = 8.54 ± 0.07). In the presence of propranolol (10-6 M), dopamine produced a dose-related contraction displaced to the right by phentolamine. Incubation with haloperidol (10-sM) did not modify the characteristics of the concentration-response curve to dopamine. 4 Pretreatment with reserpine abolished the contraction to dopamine without affecting its relaxant response. Cocaine significantly increased the pD2 value of dopamine in the presence of propranolol. 5 It is concluded that dopamine produced both relaxation of lung parenchymal strip due to direct activation of P-adrenoceptors and contraction mediated through direct and indirect (catecholamine release) actions at a-adrenoceptors. There is no evidence in favour of the existence of specific dopamine-receptors in this preparation.

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Section: Introductionmentioning

confidence: 99%

Pharmacological analysis of the responsiveness of guinea‐pig lung parenchymal strip to dopamine

Cortijo

Esplugues

Morcillo

et al. 1984

British J Pharmacology

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“…Since per- and polyfluorinated ethers display unique physiochemical properties that make them invaluable in practical applications, , considerable effort has been devoted to their synthesis. While earlier attempts relied mainly on electrochemical fluorination, extensive decomposition during this fluorination process makes it impractical to produce perfluorinated ethers on a large scale.…”

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confidence: 99%

Synthesis and Properties of Fluorinated Ethers with Fluorobenzene Rings

1996

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The physical and chemical properties exhibited by per- and polyfluorinated ethers are unique, and make this class of compounds useful in a wide range of applications. In this study, we apply siloxane derivatives of various fluoroalcohols to the preparation of fluorinated ethers containing fluorinated aromatic moieties, e.g., C6F5CF3 + (CH3)3SiOCH2(CF2)2CH2OSi(CH3)3 → [CF3C6F4OCH2CF2]2. The thermal stabilities of these polyfluorinated aromatic ethers are compared as a function of structure in the presence (or absence) of selected metals.

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Responsiveness to tyramine in isolated lung parenchymal strip of guinea-pig and rat

Morcillo

Perpiñá

Esplugues

1984

European Journal of Pharmacology

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Systemic Pharmacology of Adrenergic Activators and Inhibitors: Effects on the Respiratory System

Cited by 3 publications

References 99 publications

Pharmacological analysis of the responsiveness of guinea‐pig lung parenchymal strip to dopamine

Pharmacological analysis of the responsiveness of guinea‐pig lung parenchymal strip to dopamine

Synthesis and Properties of Fluorinated Ethers with Fluorobenzene Rings

Responsiveness to tyramine in isolated lung parenchymal strip of guinea-pig and rat

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