Systemic Photodynamic Therapy With Chlorine e6 as a Photosensitizer for the Treatment of Nodular BCC: A Case Report

Abstract

Introduction: Photodynamic therapy (PDT) is a demonstrated therapeutic method for basal cellcarcinoma (BCC), which is the most common human cancer. Here, we present a case report about systemic PDT with chlorine e6 as a photosensitizer (PS) for BCC treatment. Case Report: A 78-year-old man was diagnosed with a history of a 4-year nodular BCC in the nasal area. The patient was under control and treatment for hypertension and type 2 diabetes. Chlorine e6 was injected intravenously at a 0.08 mg/kg dosage in 500 cc normal saline within 20 minutes. Three hours after injection, laser irradiation was performed with a wavelength of 665 nm, a dosage of 150 J/cm2, and an irradiance value of 150 mW/cm2. His nodular BCC was completely cured without any side effects after one session of PDT with chlorine e6. Conclusion: Systemic PDT with chlorine e6 as a PS may be safe and effective in removing BCC lesions due to the data obtained in a two-month follow-up.

Safety and Efficacy of Photodynamic Therapy with Chlorin E6 in Chronic Central Serous Chorioretinopathy

“…Chlorin e6 has been approved by the Food and Drug Administration for use in the treatment of skin and mucosal neoplasms, including skin melanoma, basal cell carcinoma, lung cancer, and bladder cancer. [15][16][17][18][19] Fotoran E6 used in this study is currently available in Russia and several neighboring countries. The chemistry, pharmacodynamics, accumulation in tissues, and fluence parameters for PDT with chlorin e6 were initially studied experimentally in rabbits followed by clinical application in ophthalmology.…”

“…Chlorin e6 has been approved by the Food and Drug Administration for use in the treatment of skin and mucosal neoplasms, including skin melanoma, basal cell carcinoma, lung cancer, and bladder cancer. 15–19…”