Systemic reactions due to thiomersal

Tosti, Antonella; Melino, M.; Bardazzi, Federico

doi:10.1111/j.1600-0536.1986.tb01325.x

Cited by 27 publications

(5 citation statements)

References 4 publications

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“…Systemic allergic reactions seem to be very rare, but may be underdiagnosed. Acute disseminated urticaria or exanthema, eczema and an associated increase in body temperature have been reported (4,20,35). However, a positive patch test to thimerosal alone does not definitively prove a causative relation.…”

Section: Clinical Manifestations In Thimerosal Hypersensitivitymentioning

confidence: 99%

Sensitization to thimerosal (Merthiolate) is still present today

Veen

Joost

1994

Contact Dermatitis

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The results on thimerosal (Merthiolate) hypersensitivity of a retrospective study, together with the relevant data on thimerosal hypersensitivity referred to in the literature up to 1993, are presented. Positive patch test reactions to thimerosal (0.1% pet.) were observed in 32 (1.3%) of 2461 adult patients with suspected contact allergy examined in the period 1987-1992. 20 (0.8%) patients had a solitary positive patch test to thimerosal. The observed incidence is low. Clinical symptoms related to thimerosal hypersensitivity were observed in only 3 patients. The collected results are discussed with emphasis on the clinical implications of sensitization to thimerosal. It appears that a positive patch test to thimerosal is frequently clinically irrelevant.

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Section: Clinical Manifestations In Thimerosal Hypersensitivitymentioning

confidence: 99%

Sensitization to thimerosal (Merthiolate) is still present today

Veen

Joost

1994

Contact Dermatitis

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“…Thimerosal is an organic mercurial compound (sodium ethylmercurythiolate) widely used as a preservative in vaccines, solutions for intracutaneous skin testing, immunoglobulin preparations, eyedrops, and contact lens cleaning and storage solutions. In Italy, the number of positive reactions to thimerosal in patients undergoing patch testing is high (3)(4)(5)(6), but, at present, apart from single case reports (7)(8)(9)(10)13), thimerosal sensitization has been found to be clinically relevant only in patients with allergic contact conjunctivitis (3,(14)(15)(16)(17)(18)(19)(20)(21)(22). Nevertheless, some cases of generalized cutaneous reactions probably due to thimerosal-containing vaccines have been described (1,9,(23)(24)(25).…”

mentioning

confidence: 99%

Sensitization to thimerosal in atopic children

et al. 1999

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Thimerosal is an organic mercurial compound widely used as a preservative in vaccines, eyedrops, and contact lens cleaning and storage solutions. 5 infants, 2 female and 3 male, ranging in age from 7 to 28 months and affected by atopic dermatitis (AD) diagnosed according to the Hanifin and Rajka criteria, experienced an exacerbation of their clinical condition 2-10 days after mandatory vaccinations with vaccines containing thimerosal. Cutaneous lesions of nummular eczema appeared on the trunk, limbs and face. All patients were patch tested with serial dilutions of thimerosal in petrolatum. A positive patch test reaction to thimerosal 0.1% pet. was observed in all 5 children. 3 of them also showed a positive reaction at 0.01% and 0.05% pet. Despite their thimerosal-hypersensitivity, all children completed the entire series of mandatory vaccinations, care being taken to use different needles for injection and aspiration of the vaccine. The 2-year follow-up did not reveal other episodes of exacerbation of the AD after vaccination. The present study confirms the high frequency of sensitization to thimerosal in atopic children and suggests that vaccination can cause clinical symptoms in sensitized children. Nevertheless, sensitization to thimerosal does not prevent children from continuing with mandatory vaccinations.

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“…Delayed-type hypersensitivity reactions to hepatitis B vaccine are most frequently induced by the preservative, thimerosal. Hypersensitivity to thimerosal in hepatitis B vaccine has also been reported to induce a variety of other reactions, including lichen striatus type and eczematous urticarial reactions (6), and urticarial eruptions (9,10). Thimerosal hypersensitivity may also induce a generalized exanthematic eruption (9), laryngeal obstruction (11) and severe vesicular hand dermatitis (12).…”

Section: Discussionmentioning

confidence: 99%

Eczematous reaction to hepatitis B vaccine

McKenna

1999

Contact Dermatitis

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Systemic reactions due to thiomersal

Cited by 27 publications

References 4 publications

Sensitization to thimerosal (Merthiolate) is still present today

Sensitization to thimerosal (Merthiolate) is still present today

Sensitization to thimerosal in atopic children

Eczematous reaction to hepatitis B vaccine

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