This chapter examined the complex relationship between global university rankings and internationalization efforts within higher education institutions. The author addressed internationalization in higher education, covering a wide range of activities, including academic and student mobility, international research collaborations, and improving the quality of academic programs, particularly through integrating global perspectives into curricula. This study is based on the critical appraisal of the literature by examining the methodologies used by three widely recognized ranking bodies (THE, QS, and ARWU), focusing on the ranking indicators directly and indirectly related to internationalization and its impact on universities. Based on the results, the author took an inductive approach and categorized the observations into eight key challenges and strategies based on the homogeneity of the information retrieved. The identified strategies would help universities improve their global ranking performance in terms of internationalization.