Systemic sarcocystosis in a patient with acquired immune deficiency syndrome

Velásquez, Jorge Néstor; Risio, Cecilia Di; Etchart, Cristina; Chertcoff, Agustín Víctor; Méndez, Nora Hilda Segura; Cabrera, Marta; Labbé, Jorge H.; Carnevale, Silvana

doi:10.1016/j.humpath.2008.01.016

Cited by 30 publications

(13 citation statements)

References 17 publications

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“…The prevalence of this parasite in meat has been declared in many countries (Ginawi and Shommein, 1977), but unfortunately a proper investigation in Romania has not yet been published. Clinical signs of human intestinal sarcocistosis are particularly digestive system disorders such as nausea, vomiting, diarrhea (Dubey et al, 1989), which appeared especially in immunocompromised patients (Velásquez et al, 2008). According to data released by Saleque et al (1990), intestinal sarcocystosis can be prevented by thoroughly cooking or freezing meat to disablethe action of bradyzoites from the sarcocysts.…”

Section: Resultsmentioning

confidence: 99%

Molecular Identification and Prevalence of Sarcocystis Suihominis in Pork Meat Intended for Public Consumption

Fat¹,

Tăbăran²,

Dan³

et al. 2017

BUASVMCN-VM

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Protozoa of the genus Sarcocystis are among the most prevalent parasitic forms found in pork. In order to rapidly assess the risk that this protozoa produceÂ in human population, a molecular method to detect and identify Sarcocystis suihominis needs to be implemented. The study aimed at characterizing the prevalence of Sarcocystis suihominis in pork obtained in the traditional households through PCR - RFLP method. The material was represented by seventy nine samples of diaphragmatic pillars collected between the periodÂ October 2014 - December 2014 from two local sanitary veterinary units from Alba and Cluj. The samples were processed first by trichinelloscopic compression method. All the positive fragments for Sarcocystis spp. were examined through PCR-RFLP method. The method used in the present study utilized the AluI restriction enzyme and had successfully differentiate the Sarcocystis suihominis from other Sarcocystis spp. prevalent in pork meat.Â The inspection of compressed muscle tissue has detected the presence of Sarcocystis suihominis in a high percentage of investigated samples. The prevalence of Sarcocystis suihominis in the examined samples was 26.58%. According to this result we can affirm that the risk of contamination in humans with Sarcocystis suihominis is high through consumption of contaminated pork meat, raised in the traditional system. In the present scientific research, we demonstrated that this method used for molecular identification of Sarcocystis suihominis has high accuracy and can be successfully applied for obtaining a certain diagnostic.

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Section: Resultsmentioning

confidence: 99%

Molecular Identification and Prevalence of Sarcocystis Suihominis in Pork Meat Intended for Public Consumption

Fat¹,

Tăbăran²,

Dan³

et al. 2017

BUASVMCN-VM

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“…Sarcocystosis was detected in stool and in duodenal and liver biopsy specimens from a 31-year-old AIDS patient in Argentina who had chronic diarrhea, hepatitis, and muscle pain (64). Sexual stages were seen in the lamina propria, sporulated oocysts were found in the stools, and schizont-stage parasites were seen in the liver.…”

Section: Intestinal Sarcocystosis In North and South Americamentioning

confidence: 99%

Human Infections with Sarcocystis Species

2015

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SUMMARY Recurrent outbreaks of muscular sarcocystosis among tourists visiting islands in Malaysia have focused international attention on sarcocystosis, a disease once considered rare in humans. Sarcocystis species require two hosts, definitive and intermediate, to complete their life cycle. Humans can serve as definitive hosts, with intestinal sarcocystosis for two species acquired from eating undercooked meat: Sarcocystis hominis , from beef, and Sarcocystis suihominis , from pork. Symptoms such as nausea, stomachache, and diarrhea vary widely depending on the number of cysts ingested but appear more severe with pork than with beef. Humans serve as intermediate hosts for Sarcocystis nesbitti , a species with a reptilian definitive host, and possibly other unidentified species, acquired by ingesting sporocysts from feces-contaminated food or water and the environment; infections have an early phase of development in vascular endothelium, with illness that is difficult to diagnose; clinical signs include fever, headache, and myalgia. Subsequent development of intramuscular cysts is characterized by myositis. Presumptive diagnosis based on travel history to tropical regions, elevated serum enzyme levels, and eosinophilia is confirmed by finding sarcocysts in muscle biopsy specimens. There is no vaccine or confirmed effective antiparasitic drug for muscular sarcocystosis, but anti-inflammatory drugs may reduce symptoms. Prevention strategies are also discussed.

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“…The prevalence of Sarcocystis in adult bovine muscle is close to 100 % in most regions of the world (Vangeel et al 2007). In immunocompetent patients, this coccidian parasite can cause intestinal and muscular sarcocystosis (Velásquez et al 2008). Meat that is heavily infected may be condemned as unfit for human consumption.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and histopathological finding of thin-walled and thick-walled Sarcocysts in slaughtered cattle of Karaj abattoir, Iran

2013

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Sarcocystosis is a zoonotic disease caused by Sarcocystis spp. with obligatory two host life cycle generally alternating between an herbivorous intermediate host and a carnivorous definitive host. Some species of this coccidian parasite can cause considerable morbidity and mortality in cattle. The present study was set to investigate the prevalence of Sarcocystis spp. and type of cyst wall in slaughtered cattle of Karaj abattoir, Iran. For this purpose 125 cattle (88 males and 37 females) were investigated for the presence of macroscopic and microscopic Sarcocystis cysts in muscular tissues. No macroscopic Sarcocystis cysts were found in any of the samples. In light microscopy, 121 out of 125 cattle (96.8 %) had thin-walled cysts of Sarcocystis cruzi, while 43 out of them (34.4 %) had thick-walled Sarcocystis cyst. In this survey, the most infected tissue was esophagus and heart and the less was diaphragm. Thin-walled cysts (S. cruzi) mostly found in heart and skeletal muscle showed the less. However, thick-walled cyst (S. hominis or S. hirsuta) mostly were detected in diaphragm, heart muscle showed no thickwalled cyst. No significant relation was observed between age and sex and the rate of infection. The results showed that Sarcocystis cyst is prevalent in cattle in the North part of Iran and the evaluation of infection potential can be useful when considering control programs.

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Systemic sarcocystosis in a patient with acquired immune deficiency syndrome

Cited by 30 publications

References 17 publications

Molecular Identification and Prevalence of Sarcocystis Suihominis in Pork Meat Intended for Public Consumption

Molecular Identification and Prevalence of Sarcocystis Suihominis in Pork Meat Intended for Public Consumption

Human Infections with Sarcocystis Species

Prevalence and histopathological finding of thin-walled and thick-walled Sarcocysts in slaughtered cattle of Karaj abattoir, Iran

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