Systemic Sarcoidosis Presenting With a Testicular Nodule

Kg, Torrington; Pg, Lewis; Cj, Tellis; Rh, Swedarsky

doi:10.1097/00007611-197908000-00030

Cited by 14 publications

(4 citation statements)

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“…Genitourinary sarcoidosis occurs 10 times more frequently in this population (Table 1). 5,12,13 On ultrasound imaging, testicular sarcoidosis appears as hypo-echoic lesions that can mimic testicular neoplasms. 14 MRI and gallium-67 scintigraphy have been used to establish testicular involvement of sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Sarcoidosis With Testicular Involvement

Rohani

Rana

Barot

et al. 2014

Clinical Pulmonary Medicine

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Sarcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the lungs and intrathoracic lymph nodes. Testicular sarcoidosis is a rare presentation of this disease. We review the case of a patient with stage 2 sarcoidosis with bilateral intrascrotal involvement along with classic pulmonary, lymphoid, and dermatological manifestations. We provide a literature review of testicular sarcoidosis and discuss the diagnostic challenges and the management of intrascrotal mass in setting of disseminated sarcoidosis. (Clin Pulm Med 2014;21:96-100) S arcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the pulmonary system. Although the most common presentation involves granulomatous changes of the lungs and intrathoracic lymph nodes, sarcoidosis can involve almost any organ. Testicular sarcoidosis is a rare manifestation of this disease. CASE REPORTA 46-year-old male from the West Indies with a past medical history significant for Graves disease status-post radioactive ablation and chronic normocytic anemia presented to the emergency room with a chief complaint of testicular discomfort and swelling of 1-year duration. He reported increasing bilateral testicular swelling over the past year and recently had become associated with pain and discomfort. He denied any hematuria, dysuria, urinary discharge, or urinary hesitancy. He reported progressive dyspnea on exertion and a nonproductive cough for the prior 10 months. However, he denied hemoptysis, orthopnea, or paroxysmal nocturnal dyspnea. He noted 30 to 40 pounds of unintentional weight loss over the past year and the presence of nonhealing skin lesions over his right face of >10 months duration. He denied recurrent fevers, chills, or night sweats. His social history was pertinent for heterosexual intercourse with commercial sex workers. He also had a history of inhalational cocaine use 1 year before presentation but denied any tobacco use.At initial presentation, he was afebrile. Heart rate was 115 beats per minute, blood pressure was 124/73 mm Hg, respiratory rate was 16 breaths per minute, and oxygen saturation was 96% on room air.He appeared well-nourished and was not in respiratory distress. Chest auscultation revealed bilateral inspiratory crackles and expiratory wheezes. He was tachycardic with normal heart sounds. Pertinent negative findings included the absence of jugular venous distension, organomegaly, or lower extremity edema. Genitourinary examination revealed bilateral testicular fullness with mild tenderness to palpation. Also noted were multiple, raised, irregular papules on the right side of the face, the largest measuring 1.0 cm by 1.5 cm, and bilateral polygonal scaly plaques over the pretibial areas of the lower extremities that had been present since adolescence (Fig. 1).Laboratory studies revealed normocytic anemia (hemoglobin 11.6 g/dL, MCV 90 fL) with eosinophilia (8.4%) and monocytosis (18.0%). His white blood cell count was within normal range at 4000 cells/mL. His se...

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Section: Discussionmentioning

confidence: 99%

Disseminated Sarcoidosis With Testicular Involvement

Rohani

Rana

Barot

et al. 2014

Clinical Pulmonary Medicine

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“…Genitourinary tract involvement is also very rare, and only a few cases of testicular sarcoidosis, documented by either biopsy or autopsy, have been reported (Opal et al 1979;Torrington et al 1979;Haas et al 1986;Turk et al 1986;Singer et al 1990;Strawbridge et al 1990). The initial presentation can range from the more common asymptomatic, painless mass in the scrotum to the more unusual presentation of acute epididymoorchitis (Turk et al 1986).…”

Section: Discussionmentioning

confidence: 99%

“…In sarcoidosis, genitourinary involvement is rare: The frequency is less than 0.2% in clinically diagnosed cases, Offprint requests to: A. Cahid Civelek 5% in postmortem studies, and it arises 10 times more often in black men (Torrington et al 1979;Turk et al 1986;Singer etal. 1990).…”

Section: Introductionmentioning

confidence: 99%

Testicular involvement of sarcoidosis diagnosed by gallium-67 scintigraphy

et al. 1991

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“…In a patient with sarcoid and a palpable scrotal mass, the findings that would suggest benignity include involvement of the epididymis or vas deferens, bilateral testicular involvement, and/or a prior diagnosis of sarcoidosis. 11,12 However, in cases in which both testes are present, radical unilateral orchiectomy may be necessary because sonography cannot distinguish between an inflammatory and a neoplastic process. 13 Although the coexistence of testicular tumors with sarcoidosis has been reported by several investigators, [14][15][16][17][18] in some of these cases, the noncaseating granulomas appeared after therapy for a testicular tumor.…”

Section: Case Reportmentioning

confidence: 99%