Systemic scleroderma with moderate to severe mitral regurgitation: Unusual three-dimensional echocardiographic features

Khouzam, Rami N.; D’Cruz, Ivan A.; Arroyo, M.; Minderman, Daniel

doi:10.1016/s0828-282x(08)70576-2

Cited by 8 publications

(4 citation statements)

References 1 publication

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“…The implantation of a 26-mm band easily corrected the regurgitation, supporting this theory. No signs of the mitral chordal or leaflet thickening, seen previously in a patient with scleroderma, 3 or the early left ventricular dysfunction seen in patients undergoing LTx for pulmonary hypertension 4 were associated with the mechanism of regurgitation in this case. The influence of the tricuspid annuloplasty remains unclear, requiring further analysis.…”

Section: Discussionsupporting

confidence: 48%

Novel mechanism of mitral regurgitation after lung transplantation in a patient with scleroderma and pulmonary hypertension

Bermúdez

Rocha

Katz

et al. 2011

The Journal of Thoracic and Cardiovascular Surgery

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Section: Discussionsupporting

confidence: 48%

Novel mechanism of mitral regurgitation after lung transplantation in a patient with scleroderma and pulmonary hypertension

Bermúdez

Rocha

Katz

et al. 2011

The Journal of Thoracic and Cardiovascular Surgery

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“… 19–22 CTD patients suffering from aortic valve disease often suffer from concomitant mitral valve disease, with mitral regurgitation being the most common concomitant valvular lesion in SLE and mitral valve prolapse being common in SSc patients. 23 , 24 …”

Section: Discussionmentioning

confidence: 99%

Autoimmune connective tissue diseases and aortic valve replacement outcomes: a population-based study

Gad

Lichtman

Saad

et al. 2022

European Heart Journal Open

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Introduction Patients with autoimmune connective tissue diseases (CTD) have a high burden of valvular heart disease and are often thought of as high surgical risk patients. Methods Patients undergoing aortic valve replacement (AVR) were identified in the Nationwide Readmission Database (NRD) between January 2012 and December 2018. Patients with a history of systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, mixed connective tissue disease, Sjögren syndrome, polymyositis, and dermatomyositis were included in the CTD cohort. Patients undergoing coronary artery bypass grafting (CABG) concomitantly with AVR were excluded. Results A total of 569,600 hospitalizations were included, of which,16,531 (2.9%) had CTD. CTD patients were more likely to be females, with higher rates of heart failure, pulmonary hypertension, and more likely to be insured by Medicare. CTD patients had lower mortality compared to non-CTD patients (OR 0.66; 95% [CI]: 0.59-0.74); and stroke (OR 0.87; 95% [CI]: 0.79-0.97). CTD patients undergoing SAVR had lower mortality (OR 0.69; 95% [CI]: 0.60-0.80); and stroke (OR 0.86; 95% [CI]: 0.75-0.98). CTD patients undergoing TAVR had lower mortality outcomes (OR 0.67; 95% [CI]: 0.56-0.80); however, had comparable stroke outcomes (OR 0.97; 95% [CI]: 0.83-1.13, p = 0.69). Conclusions Outcomes for patients with CTD requiring AVR are not inferior to their non-CTD counterparts. A comprehensive heart team selection of patients undergoing aortic valve replacement approaches should put CTD history under consideration; however, pre-existing CTD should not be prohibitive of aortic valve replacement interventions.

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“…Systemic sclerosis is an autoimmune disorder of the connective tissue involving fibrosis of the skin and internal organs. Even though the involvement of the heart is very common, valvular involvement in systemic sclerosis is uncommon and most often involves the mitral valve causing mitral valve prolapse [ 6 ]. Aortic stenosis is an extremely rare complication [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Aortic Stenosis in Systemic Sclerosis

Kagalwalla

Gupta

Malwi

et al. 2017

Cureus

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Systemic sclerosis is a connective tissue disorder that frequently involves the heart. All cardiac structures can be involved but aortic valve involvement is rare. We report a case of an 83-year-old man with a history of systemic sclerosis presenting with shortness of breath. A transthoracic echocardiogram revealed severe aortic stenosis that could not be explained by other causes. These patients often pose challenges in management as they are not surgical candidates. Transaortic valvular implantation is a viable option for these patients.

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Systemic scleroderma with moderate to severe mitral regurgitation: Unusual three-dimensional echocardiographic features

Cited by 8 publications

References 1 publication

Novel mechanism of mitral regurgitation after lung transplantation in a patient with scleroderma and pulmonary hypertension

Novel mechanism of mitral regurgitation after lung transplantation in a patient with scleroderma and pulmonary hypertension

Autoimmune connective tissue diseases and aortic valve replacement outcomes: a population-based study

An Unusual Case of Aortic Stenosis in Systemic Sclerosis

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