Systemic sclerosis and the risk of cancer: a nationwide population-based cohort study

Abstract

Systemic sclerosis is a risk factor for cancer, particularly smoking- and alcohol-related cancers. Men with systemic sclerosis generally are at higher cancer risk than women. Both primary and secondary cancer preventive measures are needed in the care of patients with systemic sclerosis.

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

“…In addition, acquired lung diseases like obstructive and fibrotic lung diseases (e.g. chronic obstructive pulmonary disease [COPD], idiopathic pulmonary fibrosis and systemic sclerosis) are associated with increased risk of lung cancer [20][21][22].…”

Refractory anemia in systemic sclerosis: myelodisplastic syndrome

“…In many cohort, prospective, retrospective, and case control studies, hematological cancers such as non-Hodgkin lymphoma, leukaemia, multiple myeloma, and myeloproliferative neoplasms were reported in patients with SSc (3-6). A 2.5-fold increased risk for hematological cancers in a nationwide population-based cohort study was reported by Olesen et al (8) Paraneoplastic scleroderma may accompany hematologic malignancies (3,4). An increased risk for non-Hodgkin lymphoma was reported in female patients with SSc (1).…”

“…Szekanecz et al (3) observed that malignancy occured 6.6 years after the diagnosis of SSc. Diffuse cutaneous SSc compared with localised cutaneous SSc and male patients compared with female patients have a higher cancer risk (8). However, it has been reported that cancer incidence based on gender is controversial (2).…”

“…An increased risk for non-Hodgkin lymphoma was reported in female patients with SSc (1). Conversely, hematological cancer occurs more frequently in male than female patients (8). MDS secondary to rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and SSc is very rare.…”

“…However, a few case reports and series described patients with SSc and MDS (5, 6). Takashima et al (5) Genetic and environmental factors, including drugs and smoking, are involved in the multifactorial pathogenic mechanism for both SSc and MDS (8). The association between anti-centromere, anti-Scl 70 antibodies and cancer risk is not clearly known, except anti-RNA polymerase III for paraneoplastic scleroderma (7).…”