2022
DOI: 10.7759/cureus.23179
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Systemic Sclerosis (SSc) After COVID-19: A Case Report

Abstract: Since the start of the global pandemic caused by coronavirus disease 2019 (COVID-19), there have been numerous reports of autoimmune and rheumatological disorders developing after infection with SARS-CoV-2. To date, there has been only one reported case of systemic sclerosis (SSc) developing after SARS-CoV-2 infection. Here, we present another case of SSc developing after infection with SARS-CoV-2.A 48-year-old female with past medical history of anxiety and depression presented to the rheumatology clinic afte… Show more

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Cited by 9 publications
(15 citation statements)
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“…Mild thoracic, abdominal, and pelvic lymphadenopathy, non-specific. Mild mesenteric stranding may be secondary to mesenteric panniculitis, with possible pancreatitis Proteinuria Holzer et al 2022 [ 19 ] 14 < 5 CK 19,647 Positive ANA: 1:640 Positive anti-NXP2 MRI muscle: Bilateral myositis of muscles of the pelvic hip girdle and thighs Giuggioli et al 2022 [ 41 ] 28 65 Positive ANA, anticentromere pattern Nailfold capillaroscopy: “early scleroderma pattern” Chandra and Kahaleh 2022 [ 42 ] Positive ANA > 1:1280 HRCT chest: interstitial lung disease, findings suggestive of non-specific interstitial pneumonia Bouchard Marmen et al 2022 [ 43 ] 28 61 CK 7696, Positive ANA and anti-Jo-1 CT thorax: missed opacities with sub segmental consolidation MRI: oedema of the gluteal and thigh muscles consistent with myositis Blum et al 2022 [ 44 ] 91 Positive ANA Positive anti-RNP and ani-SSA antibodies CT chest: ground-glass opacities possibility indicating interstitial lung disease Assar et al 2022 [ 32 ] 18 53 …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Mild thoracic, abdominal, and pelvic lymphadenopathy, non-specific. Mild mesenteric stranding may be secondary to mesenteric panniculitis, with possible pancreatitis Proteinuria Holzer et al 2022 [ 19 ] 14 < 5 CK 19,647 Positive ANA: 1:640 Positive anti-NXP2 MRI muscle: Bilateral myositis of muscles of the pelvic hip girdle and thighs Giuggioli et al 2022 [ 41 ] 28 65 Positive ANA, anticentromere pattern Nailfold capillaroscopy: “early scleroderma pattern” Chandra and Kahaleh 2022 [ 42 ] Positive ANA > 1:1280 HRCT chest: interstitial lung disease, findings suggestive of non-specific interstitial pneumonia Bouchard Marmen et al 2022 [ 43 ] 28 61 CK 7696, Positive ANA and anti-Jo-1 CT thorax: missed opacities with sub segmental consolidation MRI: oedema of the gluteal and thigh muscles consistent with myositis Blum et al 2022 [ 44 ] 91 Positive ANA Positive anti-RNP and ani-SSA antibodies CT chest: ground-glass opacities possibility indicating interstitial lung disease Assar et al 2022 [ 32 ] 18 53 …”
Section: Resultsmentioning
confidence: 99%
“…Subsequent hydroxychloroquine 400 mg/day and prednisolone 1 mg/kg/day (dose not specified) Yes Yes Survived Kazzi et al 2022 [ 31 ] Low None SLE No Antibiotics, corticosteroids and MMF 1500 mg twice daily with resolution. Subsequent hydroxychloroquine (dose unspecified) No Yes Survived Holzer et al 2022 [ 19 ] Unknown Unknown Dermatomyositis Unknown Corticosteroids, IVIG, MMF, ciclosporin A, tofacitinib, rituximab No Yes Survived Giuggioli et al 2022 [ 41 ] Unknown Azithromycin for 5 days; hydroxychloroquine 400 mg twice a day for 1 day and then 200 mg every 12 h for 5 days Raynaud's and systemic sclerosis No Nifedipine for Raynaud’s No Yes Survived Chandra & Kahaleh 2022 [ 42 ] Unknown Unknown Systemic Sclerosis No MMF 1500 mg twice daily, amlodipine 5 mg daily, methotrexate 12.5 mg once weekly, prednisone 5 mg twice daily No No Survived Bouchard Marmen et al 2022 [ 43 ] Unknown Unknown Anti-synthetase syndrome Unknown Pulsed IV methylprednisolone, then oral prednisolone, cyclophosphamide, rituximab, IVIG Yes Yes Survived Blum et al 2022 [ 44 …”
Section: Resultsmentioning
confidence: 99%
“…There were 26 studies that proposed mechanisms related to the initiation of an autoimmune process. 6,10,15,[22][23][24]31,33,38,39,45,48,49,55,56,58,65,67,[69][70][71][73][74][75][76][77] Several studies proposed multiple possible autoimmune mechanisms. 10,24,31,39,45,48,55,73,77 Proposed mechanisms included molecular mimicry, 10,15,23,24,31,33,39,45,48,58,65,69,[73][74][75][76]…”
Section: Resultsmentioning
confidence: 99%
“…The treatment with RTX lead to B-cell depletion in patients with SSc, increasing the risk of severe manifestations of SARS-CoV-2 infection [ 60 ]. A number of case reports revealed an association of Long COVID with autoantibody production and new-onset SSc in previously infected patients without history of autoimmune diseases [ 61 , 62 ].…”
Section: Systemic Sclerosis and Long Covidmentioning
confidence: 99%