Systemic Steroid Application Caused Sudden Death of a Patient with Sudden Deafness

Ogino-Nishimura, Eriko; Nakagawa, Takayuki; Tateya, Ichiro; Hiraumi, Harukazu; Ito, Juichi

doi:10.1155/2013/734131

Cited by 8 publications

(12 citation statements)

References 6 publications

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“…A 63‐year‐old male patient with diabetes and hypertension who developed sensorineural hearing loss was treated with intravenous prednisolone. Marked hypertension and tachycardia developed within 10 h and fatal cardiac arrest occurred . Retrospectively, an adrenal tumour was present on previous imaging.…”

Section: Resultsmentioning

confidence: 99%

“…One patient also received metoclopramide, a well‐known precipitant of CC through its actions on the dopamine (D2) receptor leading to increased catecholamine release and significant vasopressor effects . In this case, metoclopramide was prescribed for nausea, well after symptom onset, This may have contributed to the severity of the CC which resulted in a fatal cardiopulmonary arrest. In two other cases of CC, other drugs were involved within the setting of chemotherapy for non‐Hodgkin's lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…Marked hypertension and tachycardia developed within 10 h and fatal cardiac arrest occurred. 8 Retrospectively, an adrenal tumour was present on previous imaging. A 33-year-old female patient with fever and headache was treated with methylprednisolone and dexamethasone.…”

Section: Therapeutic Glucocorticoid Administrationmentioning

confidence: 99%

“…6,7 Several case reports have, however, suggested a link between glucocorticoid or cosyntropin administration and a subsequent CC. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] As a result, some have suggested that biochemical testing for PPGL should be performed prior to proceeding with a DST in patients with an incidentally discovered adrenal mass. 9,25 In this study, we reviewed all cases published in the last fifty years of patients who suffered from a CC after glucocorticoid or cosyntropin administration in the setting of a known metastatic PPGL or in patients subsequently diagnosed with a pre-existing PPGL.…”

Section: Introductionmentioning

confidence: 99%

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Risk of catecholaminergic crisis following glucocorticoid administration in patients with an adrenal mass: a literature review

Barrett

Uum

Lenders

2015

Clinical Endocrinology

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Although a causal relationship cannot be established from this review, it seems prudent to exclude a PPGL in patients with a large incidentaloma or when high-dose DST is considered in a patient with an incidentaloma of any size. Our literature review does not support the need for biochemical testing for PPGL prior to a low-dose (1 mg) DST. Finally, before starting therapeutic glucocorticoids, any clinical signs or symptoms of a potential PPGL should prompt reliable biochemical testing to rule out a PPGL.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Therapeutic Glucocorticoid Administrationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Risk of catecholaminergic crisis following glucocorticoid administration in patients with an adrenal mass: a literature review

Barrett

Uum

Lenders

2015

Clinical Endocrinology

View full text Add to dashboard Cite

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“…Several case reports have noted this phenomenon. The mechanism behind this is thought to be the induction of catecholamine synthesis and the inhibition of vasodilatation in the heart and peripheral vasculature 6 7…”

Section: Discussionmentioning

confidence: 99%

Phaeochromocytoma presenting as an acute coronary syndrome

et al. 2016

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A 44-year-old Caucasian man presented to the emergency department in acute cardiogenic shock, with pulmonary oedema, secondary to an acute myocardial infarction and in a hyperosmolar hyperglycaemic state. The previous day he had undergone a colonoscopy, which revealed features of colitis, and was started on prednisolone. He had been previously diagnosed with type 2 diabetes, migraine and anxiety attacks. While awaiting a coronary angiogram he developed abdominal pain and a CT scan was performed and found a large right adrenal mass. Plasma-free metadrenaline levels were elevated. After 4 months, a right adrenalectomy was performed successfully. He made a good recovery with normalisation of his heart function and resolution of his diabetes. The diagnosis was delayed for years due to his episodic symptoms being attributed to other more common diagnoses. Although a rare diagnosis in itself, there are case reports of phaeochromocytoma initially presenting with an acute coronary syndrome.

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Adrenocorticotropic Hormone Secreting Pheochromocytoma Underlying Glucocorticoid Induced Pheochromocytoma Crisis

Geva

Gross

Mazeh

et al. 2018

Case Reports in Endocrinology

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Context Pheochromocytomas are hormone secreting tumors of the medulla of the adrenal glands found in 0.1–0.5% of patients with hypertension. The vast majority of pheochromocytomas secrete catecholamines, but they have been occasionally shown to also secrete interleukins, calcitonin, testosterone, and in rare cases adrenocorticotropic hormone. Pheochromocytoma crisis is a life threatening event in which high levels of catecholamines cause a systemic reaction leading to organ failure. Case Description A 70-year-old man was admitted with acute myocardial ischemia following glucocorticoid administration as part of an endocrine workup for an adrenal mass. Cardiac catheterization disclosed patent coronary arteries and he was discharged. A year later he returned with similar angina-like chest pain. During hospitalization, he suffered additional events of chest pain, shortness of breath, and palpitations following administration of glucocorticoids as preparation for intravenous contrast administration. Throughout his admission, the patient demonstrated both signs of Cushing's syndrome and high catecholamine levels. Following stabilization of vital parameters and serum electrolytes, the adrenal mass was resected surgically and was found to harbor an adrenocorticotropic hormone secreting pheochromocytoma. This is the first documented case of adrenocorticotropic hormone secreting pheochromocytoma complicated by glucocorticoid induced pheochromocytoma crisis. Conclusion Care should be taken when administering high doses of glucocorticoids to patients with suspected pheochromocytoma, even in a patient with concomitant Cushing's syndrome.

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Systemic Steroid Application Caused Sudden Death of a Patient with Sudden Deafness

Cited by 8 publications

References 6 publications

Risk of catecholaminergic crisis following glucocorticoid administration in patients with an adrenal mass: a literature review

Risk of catecholaminergic crisis following glucocorticoid administration in patients with an adrenal mass: a literature review

Phaeochromocytoma presenting as an acute coronary syndrome

Adrenocorticotropic Hormone Secreting Pheochromocytoma Underlying Glucocorticoid Induced Pheochromocytoma Crisis

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