Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis

Rubér, Marie; Andersson, Manne; Petersson, Bengt Fredrik; Olaison, Gunnar; Andersson, Roland; Ekerfelt, Christina

doi:10.1016/j.surg.2009.09.039

Cited by 70 publications

(75 citation statements)

References 24 publications

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“…Indeed, removal of IL-21 after 5 d of culture led to the progressive decrease of HLA-DR and CD86 expression (data not shown), suggesting that the capacity of these NK cells to modulate CD4 T lymphocytes might require the presence of IL-21 in vivo. We therefore decided to evaluate the presence of MIF and HLA-DR + NK cells in inflamed appendix where the Th17-like cytokine pattern was already described (43). Confocal microscopy analysis of these samples showed the presence of MIF + NK cells (Fig.…”

Section: Discussionmentioning

confidence: 99%

IL-21–Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor–Dependent Manner

Loyon

Picard

Mauvais

et al. 2016

The Journal of Immunology

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NK cells are critical for innate immunity–mediated protection. The main roles of NK cells rely on their cytotoxic functions or depend on the tuning of Th1 adaptive immunity by IFN-γ. However, the precise influence of inflammatory cytokines on NK cell and CD4 T lymphocyte interactions was never investigated. In this study, we provide evidence that IL-21, a cytokine produced during chronic inflammation or infectious diseases, promotes the differentiation of a specific subset of NK cells coexpressing CD86 and HLA-DR and lacking NKp44. More importantly, IL-21–propagated HLA-DR+ NK cells produce macrophage migration inhibitory factor and provide costimulatory signaling during naive CD4+ T cell priming inducing the differentiation of uncommitted central memory T cells. Central memory T cells expanded in the presence of HLA-DR+ NK cells are CXCR3+CCR6−CCR4−CXCR5− and produce IL-2, as well as low levels of TNF-α. Costimulation of CD4+ T cells by HLA-DR+ NK cells prevents the acquisition of effector memory phenotype induced by IL-2. Moreover, we identified this population of NK HLA-DR+ macrophage migration inhibitory factor+ cells in inflammatory human appendix. Collectively, these results demonstrate a novel function for IL-21 in tuning NK and CD4+ T cell interactions promoting a specific expansion of central memory lymphocytes.

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Section: Discussionmentioning

confidence: 99%

IL-21–Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor–Dependent Manner

Loyon

Picard

Mauvais

et al. 2016

The Journal of Immunology

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“…Nowadays, the progressive nature of appendicitis is questioned. Based upon epidemiological, radiological and pathological data, the idea is endorsed that two distinct types of appendicitis exist: uncomplicated (simple) and complicated (complex) appendicitis [2][3][4]. If the course of appendicitis is not progressive, the necessity of surgical removal of an uncomplicated inflamed appendix can be debated.…”

mentioning

confidence: 99%

Systematic review of nonoperative versus operative treatment of uncomplicated appendicitis

Gorter

Gorter-Stam

Eker

et al. 2017

Journal of Pediatric Surgery

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“…In a previous study, we found that CCL2, SAA and IL-6 had the highest independent discriminating capacity for appendicitis 147 . We now tested extended versions of the AIR score by the inclusion of these biochemical markers one by one.…”

Section: Construction Of the Extended Scorementioning

confidence: 75%

Structured management of patients with suspected acute appendicitis

Andersson¹

2015

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Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis

Cited by 70 publications

References 24 publications

IL-21–Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor–Dependent Manner

IL-21–Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor–Dependent Manner

Systematic review of nonoperative versus operative treatment of uncomplicated appendicitis

Structured management of patients with suspected acute appendicitis

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