Systemic therapies for salivary gland carcinomas: an overview of published clinical trials

Abstract

Background There is no consensus about effective systemic therapy for salivary gland carcinomas (sgcs). Our aim was summarized the clinical trials assessing the systemic therapies (ST) on sgcs. Material and Methods Electronic searches were carried out through MEDLINE/pubmed, EMBASE, Scopus, Web of Science, and the Cochrane Library databases, and gray literature. Results Seventeen different drugs were evaluated, and the most frequent histological subtype was adenoid cystic carcinoma ( n =195, 45.5%). STable disease, observed in 11 ST, achieved the highest rate in adenoid cystic carcinoma treated with sunitinib. The highest complete (11.1%) and partial response (30.5%) rates were seen in androgen receptor-positive tumors treated with leuprorelin acetate. Conclusions Despite all the advances in this field, there is yet no effective evidence-based regimen of ST, with all the clinical trials identified showing low rates of complete and partial responses. Further, translational studies are urgently required to characterize molecular targets and effective ST. Key words: Clinical trials, salivary gland cancer, systemic therapies.

Novel Epigenetic Modifiers of Histones Presenting Potent Inhibitory Effects on Adenoid Cystic Carcinoma Stemness and Invasive Properties

“…At present, numerous clinical trials for ACC are in progress, exploring the use of treatments such as Cetuximab, Paclitaxel, Bortezomib, and Sunitinib, among others. However, achieving a complete response to the disease remains limited [6].…”