Systemic Therapy for Mucosal, Acral, and Uveal Melanoma

Rapisuwon, Suthee; Qin, Yong; Roszik, Jason; Carapeto, Fernando; Patel, Sapna

doi:10.1007/978-3-030-05070-2_62

Cutaneous Melanoma 2020

DOI: 10.1007/978-3-030-05070-2_62

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Systemic Therapy for Mucosal, Acral, and Uveal Melanoma

Suthee Rapisuwon¹,

Yong Qin²,

Jason Roszik³

et al.

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2021

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Cited by 2 publications

References 218 publications

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High Expression of COX-2 Associated with the Depth of Invasion on Acral Melanoma by Increasing TGF-β1

Gipsyianti¹,

Aziz²,

Hernowo³

et al. 2021

CCID

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Introduction Acral melanoma (AM) has a poor prognosis since it is easily metastatic and resistant to chemo and immunotherapy. Cyclooxygenase-2 (COX-2) is an enzyme that plays a role in the carcinogenesis process. The increased expression of COX-2 has an impact on increasing levels of Myeloid-Derived Suppressor Cell (MDSC), which is a key regulator of immune. The increase in MDSC produces Transforming Growth Factor β1 (TGF-β1), which will suppress Natural Killer (NK) cells and Dendritic Cells (DC) function so that tumor cells are spared from the immune systems and are easier to invade surrounding tissues. Purpose This study aimed to determine the role of COX-2 and TGF-β1 on the depth of invasion on AM. Materials and Methods This study was a cross-sectional observational study on 40 paraffin blocks of AM cases during 2014–2019 in the Department of Pathology Anatomy, Faculty of Medicine, Dr. Hasan Sadikin General Hospital, Bandung. The depth of invasion of all samples was measured by dotSlide imaging software and the immunohistochemical staining of COX-2 and TGF-β1 was performed. The association between COX-2 and TGF-β1 expression and AM depth of invasion were analyzed using Mann Whitney. Results The result showed a significant association between COX-2 and TGF-β1 expression and depth of invasion on AM. COX-2 expression had a significant association with TGF-β1 expression (0.0001). Through multivariate analysis, it was found that COX-2 had the greatest association with the depth of invasion (p=0.0001). Conclusion The findings showed that increasing expression of COX-2 in AM is associated with the depth of invasion by increasing TGF-β1 and it might play important roles during the invasion process of AM.

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High Expression of COX-2 Associated with the Depth of Invasion on Acral Melanoma by Increasing TGF-β1

Gipsyianti¹,

Aziz²,

Hernowo³

et al. 2021

CCID

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No Overall Survival Difference in the Immunotherapy Era for Rare Subtypes of Melanoma

Safi

Trapani²,

Alradhi

et al. 2021

Pathol. Oncol. Res.

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We read with interest the article by Uprety et al. on the melanoma survival between contemporary periods depending on the approval time of immunotherapy [1]. I want to congratulate the authors for this fruitful article and make some contributions.In the study, it has been indicated that the immunotherapy era was significantly added benefits to overall survival (OS) for melanoma patients; however, the rare sites of melanoma should be included in these two contemporary groups. Unluckily, the patients with these relatively rare melanoma subtypes (acral lentiginous, uveal, and mucosal melanomas) which typically do not respond to the emerging immunotherapy that has been approved for the more common type of melanoma, and thus have worse overall survival rates [2] and attempting to reach enduring safe and effective responses in these high-risk subtypes of melanoma is one of the field's main challenges [3].We searched for the distant rare subtypes of melanoma (Stage -6th edition.

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Systemic Therapy for Mucosal, Acral, and Uveal Melanoma

Cited by 2 publications

References 218 publications

High Expression of COX-2 Associated with the Depth of Invasion on Acral Melanoma by Increasing TGF-β1

High Expression of COX-2 Associated with the Depth of Invasion on Acral Melanoma by Increasing TGF-β1

No Overall Survival Difference in the Immunotherapy Era for Rare Subtypes of Melanoma

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