Systemic Vasculitis and p-ANCA Positivity Developing in a Patient with Ulcerative Colitis and the Antiphospholipid Syndrome

Satchell, Simon C.; Anthony, P. P.; Aj, Nicholls

doi:10.1159/000045432

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…These include vasculitis of the retina (26,28,36), brain (19,23,30,34), skin (20‐22,24,33,39,40,45,50,51), muscle (25,29,44), joints (25,42,52) and lung (27,31,37,53). Moreover, the observation of antineutrophil cytoplasmic antibodies (ANCA) in some patients with UC and CD (usually perinuclear and directed against mixed epitopes) further lends credence to the hypothesis that a small vessel vasculitis could be a prominent pathogenetic mechanism in IBD (38,43,54,55).…”

Section: Introductionmentioning

confidence: 90%

“…Some will ultimately declare themselves as either ulcerative colitis (UC) or Crohn disease (CD). Others such as the primary systemic vasculitides occasionally mimic IBD (1‐18), and extraintestinal vasculitis can complicate IBD (19‐45). Thus, the differentiation between primary systemic vasculitis and IBD can be clinically challenging, but it is important to distinguish these disorders because their treatment and outcomes are different.…”

Section: Introductionmentioning

confidence: 99%

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Systemic Vasculitis

Brogan¹,

Malik²,

Shah³

et al. 2006

J. pediatr. gastroenterol. nutr.

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Extraintestinal manifestations and inflammatory responses that may be disproportionate to the degree of intestinal inflammation provide clues to the presence of an underlying primary systemic vasculitis, and these data suggest that selective visceral angiography plays a key role in the diagnosis of vasculitis in this context. It is important to identify and treat any vasculitic component because failure to do so may result in consequential morbidity or mortality.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Systemic Vasculitis

Brogan¹,

Malik²,

Shah³

et al. 2006

J. pediatr. gastroenterol. nutr.

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Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase-positive vasculitis in association with ulcerative colitis

Panani

Grigoriadou²,

Magira

et al. 2005

Clin Rheumatol

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We describe a patient with ulcerative colitis (UC) who developed small vessel vasculitis. Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase (p-ANCA-MPO) positivity was detected along with a highly elevated titer of anticardiolipin antibodies. A total proctocolectomy was undertaken and the patient, more than 5 years later, remains in very good condition. The possible causative association between the UC, the p-ANCA-MPO-positive small vessel vasculitis, and the anticardiolipin antibodies is discussed.

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Acute renal failure in a 53-year-old woman with Crohn's disease treated with 5-aminosalicylic acid

Haas

Shetye²

2001

American Journal of Kidney Diseases

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Systemic Vasculitis and p-ANCA Positivity Developing in a Patient with Ulcerative Colitis and the Antiphospholipid Syndrome

Cited by 3 publications

References 7 publications

Systemic Vasculitis

Systemic Vasculitis

Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase-positive vasculitis in association with ulcerative colitis

Acute renal failure in a 53-year-old woman with Crohn's disease treated with 5-aminosalicylic acid

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