Systemic Zygomycosis

Ellis, David

doi:10.1002/9780470688618.taw0160

Cited by 4 publications

(7 citation statements)

References 329 publications

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“…Conidiobolomycosis is a disease of the nasal submucosa and paranasal sinuses, which slowly spreads to the nasal skin, glabella, cheek, upper lip, and pharynx. Rarely, contiguous lymph nodes may be involved [ 24 , 27 , 28 , 29 , 30 ]. Infection of the nasal and paranasal mucocutaneous tissue is known as rhinoentomophthoramycosis.…”

Section: Introductionmentioning

confidence: 99%

Blooming of Unusual Cytochrome P450s by Tandem Duplication in the Pathogenic Fungus Conidiobolus coronatus

Ngwenya

Chen

Basson

et al. 2018

IJMS

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While the Zygomycete fungus Conidiobolus coronatus primarily infects insects, it can be pathogenic to mammals as well, including humans. High variability in the treatment of this fungal infection with currently available drugs, including azole drugs is a very common phenomenon. Azoles bind to the cytochrome P450 monooxygenases (P450s/CYP) including CYP51, a sterol 14-α-demethylase, inhibiting the synthesis of cell membrane ergosterol and thus leading to the elimination of infecting fungi. Despite P450’s role as a drug target, to date, no information on C. coronatus P450s has been reported. Genome-wide data mining has revealed the presence of 142 P450s grouped into 12 families and 21 subfamilies in C. coronatus. Except for CYP51, the remaining 11 P450 families are new (CYP5854-CYP5864). Despite having a large number of P450s among entomopathogenic fungi, C. coronatus has the lowest number of P450 families, which suggests blooming P450s. Further analysis has revealed that 79% of the same family P450s is tandemly positioned, suggesting that P450 tandem duplication led to the blooming of P450s. The results of this study; i.e., unravelling the C. coronatus P450 content, will certainly help in designing experiments to understand P450s’ role in C. coronatus physiology, including a highly variable response to azole drugs with respect to P450s.

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Section: Introductionmentioning

confidence: 99%

Blooming of Unusual Cytochrome P450s by Tandem Duplication in the Pathogenic Fungus Conidiobolus coronatus

Ngwenya

Chen

Basson

et al. 2018

IJMS

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“…Opportunistic fungal infections are an important cause of cutaneous necrotizing infections in immunocompromised patients, and zygomycosis in the debilitated patient is the most acute and fulminant fungal infection known 3 . Percutaneous risks for developing infection with these fungi are well described, 4 and here in, we present a case of fulminant NF caused by zygomycetes following an intramuscular injection.…”

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confidence: 81%

“…Zygomycetes class of fungi includes three orders that are Mucorales, Mortierellales and Entomophthorales. The majority of human illness is caused by the Mucorales 4 . Zygomycosis is an emerging cause of NF, and in a recent study, zygomycosis was responsible for 31.03% cases of NF 5 .…”

mentioning

confidence: 99%

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Fulminant necrotizing fasciitis caused by zygomycetes

Garg¹,

Sujatha²,

Garg³

et al. 2009

J Cutan Pathol

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“…Zygomycosis is an opportunistic infection caused by saprophytic fungi, notably species of Mucor, Rhizopus and Absidia of the family Mucoraceae, order Mucorales and class Zygomycetes (Ellis, 2005). The major predisposing factors for acquisition of zygomycosis are uncontrolled diabetes mellitus, metabolic acidosis, debilitating diseases, immunosuppression and widespread use of broadspectrum antibiotics and steroids, etc.…”

Section: Introductionmentioning

confidence: 99%

Rhinocerebral zygomycosis with pulmonary aspergillosis in a non-HIV-infected patient: an unusual case report from India

Malhotra

Duggal

Bhatia

et al. 2009

Journal of Medical Microbiology

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Zygomycosis and aspergillosis are two serious opportunistic fungal infections that are commonly seen in immunocompromised patients. Since both these fungi invade vessels of the arterial system, an early and rapid diagnosis by direct examination of KOH mounts of the relevant clinical sample can confirm the diagnosis. Here, we present an unusual case of a diabetic patient who presented with nasal blockade and bleeding for 2 months, along with occasional haemoptysis for 15 days. On investigation, the patient was diagnosed with a case of rhinocerebral zygomycosis and was treated with amphotericin B (1 mg kg−1 day−1), which was subsequently replaced with liposomal amphotericin B (2 mg kg−1 day−1). However, the patient did not completely respond to therapy as haemoptysis continued. Further investigations revealed the presence of Aspergillus flavus in respiratory specimens. Thus, a final diagnosis of rhinocerebral zygomycosis with pulmonary aspergillosis in a non-HIV-infected patient was made, but due to infection of two vital sites by these fungi, the patient could not be saved.

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Systemic Zygomycosis

Cited by 4 publications

References 329 publications

Blooming of Unusual Cytochrome P450s by Tandem Duplication in the Pathogenic Fungus Conidiobolus coronatus

Blooming of Unusual Cytochrome P450s by Tandem Duplication in the Pathogenic Fungus Conidiobolus coronatus

Fulminant necrotizing fasciitis caused by zygomycetes

Rhinocerebral zygomycosis with pulmonary aspergillosis in a non-HIV-infected patient: an unusual case report from India

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