Systemically Administered α2-Agonist-induced Peripheral Vasoconstriction in Humans

Talke, Pekka; Lobo, Errol; Brown, Ronald C.

doi:10.1097/00000542-200307000-00014

Cited by 179 publications

(137 citation statements)

References 12 publications

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“…This was administered via TCI. A Harvard Model 22 syringe pump (Harvard Apparatus) connected to a portable computer running STANPUMP software (by Steven L. Schafer, MD, available at http://www.opentci.org/doku.php?idϭcode:code) and the pharmacokinetic parameters of Talke (2003) were used. In Session 1, the infusion was started at a target (plasma) concentration of 1.0 ng/ml, followed first by a 0.5 ng/ml target concentration increase, and then by subsequent 0.25 ng/ml increases thereafter (i.e., 1.0 to 1.5, 1.5 to 1.75, 1.75 to 2.0, and 2.0 to 2.25 ng/ml) until LOC was achieved.…”

Section: Anesthesia Sessionsmentioning

confidence: 99%

Returning from Oblivion: Imaging the Neural Core of Consciousness

Långsjö

Alkire²,

Kaskinoro³

et al. 2012

J. Neurosci.

192

147

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One of the greatest challenges of modern neuroscience is to discover the neural mechanisms of consciousness and to explain how they produce the conscious state. We sought the underlying neural substrate of human consciousness by manipulating the level of consciousness in volunteers with anesthetic agents and visualizing the resultant changes in brain activity using regional cerebral blood flow imaging with positron emission tomography. Study design and methodology were chosen to dissociate the state-related changes in consciousness from the effects of the anesthetic drugs. We found the emergence of consciousness, as assessed with a motor response to a spoken command, to be associated with the activation of a core network involving subcortical and limbic regions that become functionally coupled with parts of frontal and inferior parietal cortices upon awakening from unconsciousness. The neural core of consciousness thus involves forebrain arousal acting to link motor intentions originating in posterior sensory integration regions with motor action control arising in more anterior brain regions. These findings reveal the clearest picture yet of the minimal neural correlates required for a conscious state to emerge.

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Section: Anesthesia Sessionsmentioning

confidence: 99%

Returning from Oblivion: Imaging the Neural Core of Consciousness

Långsjö

Alkire²,

Kaskinoro³

et al. 2012

J. Neurosci.

192

147

View full text Add to dashboard Cite

show abstract

“…In the present study, total intravenous anesthesia with propofol and remifentanil combined with dexmedetomidine maintained HR at a lower level, reduced bleeding and improved surgical satisfaction scores. In addition, unlike anesthetic drugs which dilate blood vessels, dexmedetomidine constricts peripheral arteries and veins (27). Although there is no clear clinical evidence that dexmedetomidine can contract blood vessels in the nasal mucosa, it is not ruled out that reducing bleeding may be associated with vasoconstriction.…”

Section: Discussionmentioning

confidence: 99%

Target‑controlled infusion of propofol and remifentanil combined with dexmedetomidine reduces functional endoscopic sinus surgery bleeding

Ding

Wang

et al. 2017

Exp Ther Med

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“…Same authors in another experimental study reported that clinically relevant doses of dexmedetomidine enhanced blockade when added to ropivacaine 13 . Dexmedetomidine may lead to side effects such as hypotension and bradycardia with increased dosage, along with its effects such as sedation and anxiolysis 14 . In this study the incidence of bradycardia was high, despite the absence of hypotension in the RD group.…”

Section: Discussionmentioning

confidence: 99%