Systemischer Lupus erythematodes

Boedecker, Simone; Weinmann‐Menke, Julia

doi:10.1007/s11560-021-00519-w

Cited by 2 publications

(2 citation statements)

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“…SLE is a chronic, recurrent, potentially fatal multisystem autoimmune and inflammatory connective tissue disorder whose diagnosis can be difficult due to the broad range of clinical manifestations and the lack of pathognomic features or specific laboratory tests 7–9 . SLE can be fatal due to its potential to cause premature death, primarily because of active disease, organ failure (e.g., kidneys), infection, or cardiovascular disease resulting from accelerated atherosclerosis 10 . Before puberty, the female‐to‐male ratio of SLE occurrence is 3:1; after puberty, the ratio increases to 9:1.…”

Section: Case Discussionmentioning

confidence: 99%

“… 7 , 8 , 9 SLE can be fatal due to its potential to cause premature death, primarily because of active disease, organ failure (e.g., kidneys), infection, or cardiovascular disease resulting from accelerated atherosclerosis. 10 Before puberty, the female‐to‐male ratio of SLE occurrence is 3:1; after puberty, the ratio increases to 9:1. SLE is generally classified into chronic cutaneous LE (CCLE), subacute cutaneous LE (SCLE), and acute cutaneous LE (ACLE).…”

Section: Case Discussionmentioning

confidence: 99%

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Systemic lupus erythematosus associated with erythema multiforme: A rare case report of Rowell's syndrome

Bhattarai,

Sharma,

Paudel

et al. 2024

Clinical Case Reports

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Key Clinical MessageAlthough it is very uncommon, SLE may initially present with recurrent episodes of EM‐like rash. Despite the various possibilities underlying their association, prompt identification, and treatment of SLE in patients presenting with EM is important to prevent death or serious organ damage.AbstractRowell's syndrome (RS) is an uncommon presentation of systemic lupus erythematosus (SLE) with erythema multiforme (EM)‐like lesions associated with specific serological changes, including positive rheumatoid factor (RF), speckled antinuclear antibody (ANA), positive rheumatoid factor, or anti‐La antibodies in the serum. Our case, a 41‐year‐old male, presented with features of EM. Upon investigation, we identified underlying systemic lupus erythematosus, marking a rare instance of SLE presenting for the first time as EM. Classical or true EM is precipitated by trigger factors such as infective agents like the herpes simplex virus, Mycoplasma pneumoniae, drugs like anticonvulsants, antibiotics, and non‐steroid anti‐inflammatory drugs, any underlying malignancy, or connective tissue disorders, and is not associated with any specific serological abnormalities. EM cases associated with LE lesions where an EM trigger factor is missing are considered an RS diagnostic criterion. In this case report, the importance of considering SLE in patients presenting initially with recurrent episodes of EM‐like rash is emphasized. RS should be considered, especially when there is no evidence of triggering factors. Early diagnosis and prompt treatment of SLE are crucial to preventing death and irreversible organ damage.

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Section: Case Discussionmentioning

confidence: 99%