Systems biology approaches to investigating the roles of extracellular vesicles in human diseases

Gézsi, András; Kovács, Árpád Ferenc; Visnovitz, Tamás; Buzás, Edit I.

doi:10.1038/s12276-019-0226-2

Cited by 49 publications

(49 citation statements)

References 160 publications

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“…Extracellular vesicles can encapsulate small portions of the subjacent cytosol, creating a heterogeneous population of phospholipid-walled vesicles, which play an important role in intercellular communication, immune response, angiogenesis, and signal transduction, in both physiological and pathological conditions [8].…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication

Battistelli

Falcieri

2020

Biology

323

244

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In the last decade, a new method of cell–cell communication mediated by membranous extracellular vesicles (EVs) has emerged. EVs, including exosomes, microvesicles, and apoptotic bodies (ApoBDs), represent a new and important topic, because they are a means of communication between cells and they can also be involved in removing cellular contents. EVs are characterized by differences in size, origin, and content and different types have different functions. They appear as membranous sacs released by a variety of cells, in different physiological and patho-physiological conditions. Intringuingly, exosomes and microvesicles are a potent source of genetic information carriers between different cell types both within a species and even across a species barrier. New, and therefore still relatively poorly known vesicles are apoptotic bodies, on which numerous in-depth studies are needed in order to understand their role and possible function. In this review we would like to analyze their morpho-functional characteristics.

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Section: Extracellular Vesiclesmentioning

confidence: 99%

Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication

Battistelli

Falcieri

2020

Biology

323

244

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“…d. Characterization of dynamic relationships between different species in model holobionts by the application of the Systems Biology point of view, with the help of artificial intelligence algorithms for the integration of "omics" data, together with environmental factors [101,153].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Interspecies Communication in Holobionts by Non-Coding RNA Exchange

Leitão

Costa

Gabriel

et al. 2020

IJMS

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Complex organisms are associations of different cells that coexist and collaborate creating a living consortium, the holobiont. The relationships between the holobiont members are essential for proper homeostasis of the organisms, and they are founded on the establishment of complex inter-connections between all the cells. Non-coding RNAs are regulatory molecules that can also act as communication signals between cells, being involved in either homeostasis or dysbiosis of the holobionts. Eukaryotic and prokaryotic cells can transmit signals via non-coding RNAs while using specific extracellular conveyors that travel to the target cell and can be translated into a regulatory response by dedicated molecular machinery. Within holobionts, non-coding RNA regulatory signaling is involved in symbiotic and pathogenic relationships among the cells. This review analyzes current knowledge regarding the role of non-coding RNAs in cell-to-cell communication, with a special focus on the signaling between cells in multi-organism consortia.

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“…Some EVs contain DNAs, such as single-stranded DNA (ssDNA), mitochondrial DNA (mtDNA), and double-stranded DNA (dsDNA) [ 58 ]. They may range in size from 100 to several thousand base pairs [ 59 ] and, sometimes, even 2 million base pairs [ 60 ].…”

Section: Origin and Composition Of Naturally Secreted Evsmentioning

confidence: 99%

Extracellular Vesicle- and Extracellular Vesicle Mimetics-Based Drug Delivery Systems: New Perspectives, Challenges, and Clinical Developments

Gangadaran

Ahn

2020

Pharmaceutics

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Extracellular vesicles (EVs) are small membrane-based nanovesicles naturally released from cells. Extracellular vesicles mimetics (EVMs) are artificial vesicles engineered from cells or in combination with lipid materials, and they mimic certain characteristics of EVs. As such, EVs facilitate intracellular communication by carrying and delivering biological materials, such as proteins, lipids, and nucleic acids, and they have been found to find organ tropism in preclinical studies. Because of their native structure and characteristics, they are considered promising drug carriers for future clinical use. This review outlines the origin and composition of natural EVs and EVM engineering and internalization. It then details different loading approaches, with examples of the drug delivery of therapeutic molecules. In addition, the advantages and disadvantages of loading drugs into EVs or EVMs as a drug delivery system are discussed. Finally, the advantages of EVMs over EVs and the future clinical translation of EVM-based drug delivery platforms are outlined.

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Systems biology approaches to investigating the roles of extracellular vesicles in human diseases

Cited by 49 publications

References 160 publications

Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication

Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication

Interspecies Communication in Holobionts by Non-Coding RNA Exchange

Extracellular Vesicle- and Extracellular Vesicle Mimetics-Based Drug Delivery Systems: New Perspectives, Challenges, and Clinical Developments

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