Systems biology for nursing in the era of big data and precision health

Founds, Sandra A.

doi:10.1016/j.outlook.2017.11.006

Cited by 25 publications

(15 citation statements)

References 50 publications

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“…From a systems biology conceptual framework in which the whole is greater than the sum of its parts, subsets or different types of preeclampsia may be better elucidated by integrating women’s symptom experiences with biophysical and behavioral factors to phenotype this disorder across gestation (Founds, 2009; Founds, 2017). Although symptoms have been considered to be nonspecific for the diagnosis of preeclampsia or its extremely severe form, hemolysis, elevated liver enzymes, or low platelets (HELLP) syndrome, clinicians at prenatal visits routinely inquire about persistent headache, visual disturbance, and epigastric or right upper abdominal pain as hallmark “warning signs” of abnormality (ACOG, 2013).…”

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confidence: 99%

Associating Symptom Phenotype and Genotype in Preeclampsia

Founds

Tsigas

Ren

et al. 2018

Biological Research For Nursing

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Preeclampsia is a complex genetic disorder with an incompletely understood pathogenesis. Its phenotype may be better elucidated by integrating symptoms. This study aimed to identify symptoms by gestational age and associations with novel preeclampsia candidate genes. Women with a history of preeclampsia recruited from The Preeclampsia Registry completed clinical/demographic, symptom surveys and provided medical records. DNA extracted from saliva was processed with multiplexed assays for eight single-nucleotide polymorphisms (SNPs) selected to tag candidate genes and/or located in symptom susceptibility regions. Groups with versus without symptoms were compared using χ. Associations between SNPs and symptoms were analyzed as genotype categories and presence/absence of the variant allele. Logistic regression modeling was conducted with exploratory p = .05. In 114 participants, 113 reported at least 1 of the 18 symptoms. Symptoms varied by trimester. Nine symptoms were associated with seven SNPs. Visual disturbances were associated with three SNPs and nausea/vomiting with two SNPs. Modeling adjustment for maternal age and parity resulted in 15 associations between 9 symptoms and 8 SNPs. Medical records demonstrated 100% concordance with self-reported diagnosis and 48% concordance with reported severity. Findings indicated novel symptom-genotype associations in preeclampsia. The small sample was self-selected, but results support future studies including medical records review. When validated, these results may lead to holistic phenotyping of women to characterize subsets of preeclampsia. This approach may optimize health in pregnancy and later life for mothers and offspring through prediction, prevention, and precision nursing care.

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confidence: 99%

Associating Symptom Phenotype and Genotype in Preeclampsia

Founds

Tsigas

Ren

et al. 2018

Biological Research For Nursing

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“…Founds revisited her theory showing the intersection of big data and prediction medicine with the systems biology with the P4 medicine [34]. This further enhances the application of it in nursing research, education, and practice, so that it can apply ongoing developments in omics and big data to a holistic precision health framework.…”

Section: ) Nursingmentioning

confidence: 95%

A General Systems Theory Approach in Public Hearing Health: Lessons Learned From a Systematic Review of General Systems Theory in Healthcare

et al. 2020

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General Systems Theory (GST), as it was introduced by Karl Ludwig von Bertalannfy, had a significant, yet mostly unacknowledged influence on systems theory. The purpose of the current review is to highlight and assess the application of the aforementioned theory in the healthcare field and suggest a new approach to the public hearing healthcare sector. A systematic literature review has been conducted in the electronic databases of ScienceDirect, Pubmed and IEEEXplore covering the years of 2009-2019, following the PRISMA guidelines. The article selection was performed to identify GST-related frameworks in the healthcare field and was completed through a process of removing duplicates and non-available articles, analyzing the tittle and abstract, and then reviewing the full text of each selected article. In the final analysis, 47 studies were selected and were thoroughly analysed. Almost half of these articles showed a practical implementation of GST-inspired frameworks, following different types of research methodology. Analysis of these methodologies identified the limitations and positive effects of GST in the healthcare field. Although there is a significant number of references in GST in the healthcare field over the last 10 years, applications of it need to be further tested and explored before they are put into real-situation testing. Simulation models and evidence-based approaches on a micro-, meso-and macro-level of systems should be used to provide the contextual information needed for establishing GST as a driving force in the healthcare field. To this context, a paradigm of GST data framework applied to the hearing loss screening area is hereby presented and discussed. It is shown that a GST approach can be used to identify equilibria in all levels, to balance gain and prediction capacity over time and enhance public hearing health approaches for treatment and management strategies. INDEX TERMS General systems theory, hearing healthcare, systemic approach, systematic review, public hearing health.

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“…The Council for the Advancement of Nursing Science Scientifi c Committee advocates for the importance of the nursing lens in research to address key aspects that promote health, well-being, and health-related quality of life (Eckardt et al, 2017 ). This nursing lens assumes the centrality of the individual as a whole (i.e., a holistic systems biology framework) (Founds, 2018 ); it is imperative that nursing ' s holistic focus be brought to the science around regenerative technologies. Central to nursing engagement in regenerative science is the iterative development of evidence-based, disease-specifi c, and regenerative therapy-tailored frameworks to assist and guide providers in the management of patients (Howell et al, 2018 ;Trounson, DeWitt, & Feigal, 2012 ).…”

Section: Opportuni Es For Nursing Science In Regenera Ve Health Carementioning

confidence: 99%

The Regenerative Horizon: Opportunities for Nursing Research and Practice

Chlan

Tofthagen

Terzic

2019

J of Nursing Scholarship

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Background: Regenerative technologies aim to restore organ form and function. Technological advances in regenerative treatments have led to patients increasingly seeking these therapies. The readiness of nursing to fully contribute to this emerging healthcare field is uncertain. Purpose: The goal of this discipline-oriented overview is to enhance awareness in the nursing community regarding regenerative science, and to provide suggestions for nursing research contributions and practice implications. Methods: Evolving and applied cutting-edge therapies, such as regenerative immunotherapies with chimeric antigen receptor expressing T lymphocytes, are highlighted in the context of emerging opportunities for nurses in practice and research. Discussion: Next generation nurses will increasingly be at the forefront of new therapies poised to make chronic illnesses curable, thus restoring health and function to diverse groups of individuals. Clinical Relevance: The regenerative care model imposes on the nursing community the imperative to (a) increase research awareness; (a) educate, develop, and deploy a skilled nursing workforce; (c) integrate regenerative technologies into nursing practice; and (d) embrace the regenerative technologies horizon as a future in health care.

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Systems biology for nursing in the era of big data and precision health

Cited by 25 publications

References 50 publications

Associating Symptom Phenotype and Genotype in Preeclampsia

Associating Symptom Phenotype and Genotype in Preeclampsia

A General Systems Theory Approach in Public Hearing Health: Lessons Learned From a Systematic Review of General Systems Theory in Healthcare

The Regenerative Horizon: Opportunities for Nursing Research and Practice

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