Systems Biology in Livestock Health and Disease

Kirby, Gordon M.

doi:10.1002/9780470963012.ch4

Cited by 4 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 Illustrative interventions for the management of post-weaning diarrhea in pig farms. Asterisk Vaccination just prior to or at weaning (Inspired from [ 159 ]) …”

Section: Introductionmentioning

confidence: 99%

Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies

et al. 2017

View full text Add to dashboard Cite

Post-weaning diarrhea (PWD) is one of the most serious threats for the swine industry worldwide. It is commonly associated with the proliferation of enterotoxigenic Escherichia coli in the pig intestine. Colistin, a cationic antibiotic, is widely used in swine for the oral treatment of intestinal infections caused by E. coli, and particularly of PWD. However, despite the effectiveness of this antibiotic in the treatment of PWD, several studies have reported high rates of colistin resistant E. coli in swine. Furthermore, this antibiotic is considered of very high importance in humans, being used for the treatment of infections due to multidrug-resistant (MDR) Gram-negative bacteria (GNB). Moreover, the recent discovery of the mcr-1 gene encoding for colistin resistance in Enterobacteriaceae on a conjugative stable plasmid has raised great concern about the possible loss of colistin effectiveness for the treatment of MDR-GNB in humans. Consequently, it has been proposed that the use of colistin in animal production should be considered as a last resort treatment only. Thus, to overcome the economic losses, which would result from the restriction of use of colistin, especially for prophylactic purposes in PWD control, we believe that an understanding of the factors contributing to the development of this disease and the putting in place of practical alternative strategies for the control of PWD in swine is crucial. Such alternatives should improve animal gut health and reduce economic losses in pigs without promoting bacterial resistance. The present review begins with an overview of risk factors of PWD and an update of colistin use in PWD control worldwide in terms of quantities and microbiological outcomes. Subsequently, alternative strategies to the use of colistin for the control of this disease are described and discussed. Finally, a practical approach for the control of PWD in its various phases is proposed.

show abstract

“…3 Illustrative interventions for the management of post-weaning diarrhea in pig farms. Asterisk Vaccination just prior to or at weaning (Inspired from [ 159 ]) …”

Section: Introductionmentioning

confidence: 99%

Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies

et al. 2017

View full text Add to dashboard Cite

show abstract

Meat science: From proteomics to integrated omics towards system biology

D’Alessandro

Zolla

2013

Journal of Proteomics

133

View full text Add to dashboard Cite

Omics in Livestock Animals: Improving Health, Well-being and Production

Sharma,

Chauhan,

Kumar

et al. 2023

Systems Biology, Bioinformatics and Livestock Science

View full text Add to dashboard Cite

India has an extensive livestock wealth with a growing rate of 6% per annum with a crucial role in the Indian economy. The livestock sector is one of the important subsectors of agriculture, which contributes 25.6% of total agriculture GDP. The arrival of deep sequencing technologies such as Next Generation Sequencing (NGS) and Single Cell Sequencing (SCS) has produced huge sequence data that can be exploited to advance well being, health, reproduction and yield of livestocks by employment of integrated omics strategies. The current era of omics, i.e., genomics, transcriptomics, proteomics, metabolomics, translatomics and single-cell sequencing, has considerably improved researcher's understanding of livestock research at the gene level and opened new avenues in terms of single-cell studies, which need to be carried out in the near future. NGS plays a crucial role in understanding the genetic mechanism of animal’s functions and its interaction with the environment. Furthermore, the SCS will provide insight into the functions of cell types in livestock species. The data generated using NGS and SCS approaches may help to discover novel molecular markers from the complete genome and develop global diagnostic methods for the detection of infectious diseases and their agents.

show abstract

Systems Biology in Livestock Health and Disease

Cited by 4 publications

References 44 publications

Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies

Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies

Meat science: From proteomics to integrated omics towards system biology

Omics in Livestock Animals: Improving Health, Well-being and Production

Contact Info

Product

Resources

About