Systems biology of human aging: A Fibonacci time series model

Sacco, Robert G.; Torday, John S.

doi:10.1016/j.pbiomolbio.2022.10.005

Cited by 7 publications

(2 citation statements)

References 91 publications

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“…The human body is also a multiscale system, and its macroscopic energy dissipation during growth could also lead to the development of organs characterized by smaller D [308,309]. However, once growth stops in adulthood, macroscopic dissipation ceases, and humans only dissipate energy at the microscopic scale, resulting in an increase in D. That is why Sections 7.4 and 7.5 provide examples of this process.…”

Section: Summary and Discussionmentioning

confidence: 99%

The Multiscale Principle in Nature (Principium luxuriæ): Linking Multiscale Thermodynamics to Living and Non-Living Complex Systems

Venegas-Aravena,

Cordaro

2024

Fractal Fract

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Why do fractals appear in so many domains of science? What is the physical principle that generates them? While it is true that fractals naturally appear in many physical systems, it has so far been impossible to derive them from first physical principles. However, a proposed interpretation could shed light on the inherent principle behind the creation of fractals. This is the multiscale thermodynamic perspective, which states that an increase in external energy could initiate energy transport mechanisms that facilitate the dissipation or release of excess energy at different scales. Within this framework, it is revealed that power law patterns, and to a lesser extent, fractals, can emerge as a geometric manifestation to dissipate energy in response to external forces. In this context, the exponent of these power law patterns (thermodynamic fractal dimension D) serves as an indicator of the balance between entropy production at small and large scales. Thus, when a system is more efficient at releasing excess energy at the microscopic (macroscopic) level, D tends to increase (decrease). While this principle, known as Principium luxuriæ, may sound promising for describing both multiscale and complex systems, there is still uncertainty about its true applicability. Thus, this work explores different physical, astrophysical, sociological, and biological systems to attempt to describe and interpret them through the lens of the Principium luxuriæ. The analyzed physical systems correspond to emergent behaviors, chaos theory, and turbulence. To a lesser extent, the cosmic evolution of the universe and geomorphology are examined. Biological systems such as the geometry of human organs, aging, human brain development and cognition, moral evolution, Natural Selection, and biological death are also analyzed. It is found that these systems can be reinterpreted and described through the thermodynamic fractal dimension. Therefore, it is proposed that the physical principle that could be behind the creation of fractals is the Principium luxuriæ, which can be defined as “Systems that interact with each other can trigger responses at multiple scales as a manner to dissipate the excess energy that comes from this interaction”. That is why this framework has the potential to uncover new discoveries in various fields. For example, it is suggested that the reduction in D in the universe could generate emergent behavior and the proliferation of complexity in numerous fields or the reinterpretation of Natural Selection.

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Section: Summary and Discussionmentioning

confidence: 99%

The Multiscale Principle in Nature (Principium luxuriæ): Linking Multiscale Thermodynamics to Living and Non-Living Complex Systems

Venegas-Aravena,

Cordaro

2024

Fractal Fract

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“…Recent advancements in time series analysis have offered a mathematical framework for studying these mechanisms based on the Fibonacci sequence [4]. The Fibonacci sequence, a series of numbers in which each number is the sum of the two preceding ones, has been found to have applications in various natural phenomena, including the growth patterns of plants, structure of galaxies, and even the stock market [5].…”

Section: Introductionmentioning

confidence: 99%

Fractal Dynamics and Fibonacci Sequences: A Time Series Analysis of Cultural Attractor Landscapes

G. Sacco

2024

Time Series Analysis - Recent Advances, New Perspectives and Applications

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This study explores the intricate relationship between fractal structures and cultural evolution through time series analysis. Utilizing Fibonacci time series modeling, the author predicts the formation and stabilization of cultural attractors—emergent phenomena that arise from dynamic populations within cognitive landscapes. The model backtests significant milestones in human cultural history, ranging from the Copper Age to the Internet era, and correlates them with Fibonacci time series. The findings suggest that cognitive development, demographic structure, and cultural transmission are key factors that influence the self-organization and dynamic stabilization of cultural attractor landscapes. This study offers a novel perspective on the optimization of information flow in cultural evolution and has implications for interdisciplinary studies in computer science, mathematics, statistics, and geography.

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Fibonacci’s Blueprint in Lifespan: Integrating Mathematical Predictions with RNA Dynamics and DNA Heritability in Systems Biology

Sacco,

Torday

2024

RNA Technologies

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Systems biology of human aging: A Fibonacci time series model

Cited by 7 publications

References 91 publications

The Multiscale Principle in Nature (Principium luxuriæ): Linking Multiscale Thermodynamics to Living and Non-Living Complex Systems

The Multiscale Principle in Nature (Principium luxuriæ): Linking Multiscale Thermodynamics to Living and Non-Living Complex Systems

Fractal Dynamics and Fibonacci Sequences: A Time Series Analysis of Cultural Attractor Landscapes

Fibonacci’s Blueprint in Lifespan: Integrating Mathematical Predictions with RNA Dynamics and DNA Heritability in Systems Biology

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