Systems Biology of Selenium and Complex Disease

Ying, Huimin; Zhang, Yan

doi:10.1007/s12011-019-01781-9

Cited by 38 publications

(28 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the existing data demonstrate that selenoproteins are both directly and indirectly involved in a myriad of metabolic pathways. However, the particular patterns of altered selenoprotein expression and function and their roles in pathogenesis of various diseases are yet to be estimated [47].…”

Section: A Brief Introduction Into Selenoprotein Functionmentioning

confidence: 99%

Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

et al. 2020

View full text Add to dashboard Cite

Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development and in adipocyte metabolism are unclear. The objective of the present study is to review the current data on Se status in obesity and to discuss the interference between Se and selenoprotein metabolism in adipocyte physiology and obesity pathogenesis. The overview and meta-analysis of the studies on blood Se and selenoprotein P (SELENOP) levels, as well as glutathione peroxidase (GPX) activity in obese subjects, have yielded heterogenous and even conflicting results. Laboratory studies demonstrate that Se may modulate preadipocyte proliferation and adipogenic differentiation, and also interfere with insulin signaling, and regulate lipolysis. Knockout models have demonstrated that the selenoprotein machinery, including endoplasmic reticulum-resident selenoproteins together with GPXs and thioredoxin reductases (TXNRDs), are tightly related to adipocyte development and functioning. In conclusion, Se and selenoproteins appear to play an essential role in adipose tissue physiology, although human data are inconsistent. Taken together, these findings do not support the utility of Se supplementation to prevent or alleviate obesity in humans. Further human and laboratory studies are required to elucidate associations between Se metabolism and obesity.

show abstract

Section: A Brief Introduction Into Selenoprotein Functionmentioning

confidence: 99%

Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The essential nature of this trace element for biochemical reactions in living cells can be easily understood when considering that Se constitutes part of the amino acids selenocysteine (Sec) and selenomethionine (SeMet) [35][36][37]. Sec is present in three major enzyme families (glutathione peroxidases, thioredoxine reductases, and iodothyronine deiodinases) and also in several selenoproteins [38]. Most of these enzyme secproteins are involved in cell oxide-reduction reactions, organism reproduction, thyroid gland/ hormone metabolism, and immune reaction responses [35].…”

Section: Discussionmentioning

confidence: 99%

Lateralized spontaneous exploratory behavior in maturing rats induced by new geometrically differentiated environments after administration with trace elements

Ratti¹,

Sacchi²,

Alvarez³

2019

Journal of Neurorestoratology

View full text Add to dashboard Cite

Functional laterality is known as an intrinsic property of the brain. Since several studies have shown the presence of laterality in many species other than humans, it has been suggested that this is an adaptive mechanism to aid survival. Previous studies have shown that lateralized behavior observed during exposure to different environmental stimuli is not constant in normal animals, depending on the geometrical form of the exploratory field. In these exploratory fields, animals showed right- or left-biased exploratory behavior, according to the nature of the geometrical properties of the environment. Previously, it was found that tellurium (Te) was able to block spontaneous left-biased exploration in one defined geometrical environment. In the present work, the influence of Te and selenium (Se) in animals exposed to novel geometrically different environments were studied. Three geometrically different testing fields (square, rectangle, and T-shaped) were presented to Se- and Te-treated groups of rats. The results show that in the square field, only the Se treatment was able to block spontaneous right-biased exploratory responses; in the rectangular field, both Se and Te treatments blocked right-biased exploratory responses, and in the T-shaped field, only Te was able to block spontaneous left-biased exploratory responses. Data suggest that trace elements modify lateralized behavioral responses independently of the form of the novel exploratory field, suggesting the presence of a specific action in the brain.

show abstract

“…Se is a metalloid trace element, which is essential for normal physiological functions in humans, animals, and many other organisms [5,105]. It mainly occurs in the form of Sec, which is a key component of selenoproteins involved in numerous enzymatic reactions, such as redox homeostasis, thyroid hormone metabolism, anti-inflammatory actions, and reproduction [106,107].…”

Section: Seleniummentioning

confidence: 99%

Bioinformatics of Metalloproteins and Metalloproteomes

Zhang

Zheng

2020

Molecules

Self Cite

View full text Add to dashboard Cite

Trace metals are inorganic elements that are required for all organisms in very low quantities. They serve as cofactors and activators of metalloproteins involved in a variety of key cellular processes. While substantial effort has been made in experimental characterization of metalloproteins and their functions, the application of bioinformatics in the research of metalloproteins and metalloproteomes is still limited. In the last few years, computational prediction and comparative genomics of metalloprotein genes have arisen, which provide significant insights into their distribution, function, and evolution in nature. This review aims to offer an overview of recent advances in bioinformatic analysis of metalloproteins, mainly focusing on metalloprotein prediction and the use of different metals across the tree of life. We describe current computational approaches for the identification of metalloprotein genes and metal-binding sites/patterns in proteins, and then introduce a set of related databases. Furthermore, we discuss the latest research progress in comparative genomics of several important metals in both prokaryotes and eukaryotes, which demonstrates divergent and dynamic evolutionary patterns of different metalloprotein families and metalloproteomes. Overall, bioinformatic studies of metalloproteins provide a foundation for systematic understanding of trace metal utilization in all three domains of life.

show abstract

Systems Biology of Selenium and Complex Disease

Cited by 38 publications

References 146 publications

Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

Lateralized spontaneous exploratory behavior in maturing rats induced by new geometrically differentiated environments after administration with trace elements

Bioinformatics of Metalloproteins and Metalloproteomes

Contact Info

Product

Resources

About