Systems Challenges of Hepatic Carcinomas: A Review

Abstract

Hepatocellular Carcinoma (HCC) is ubiquitous in its prevalence in most of the developing countries. In the era of systems biology, multi-omics has evinced an extensive approach to define the underlying mechanism of disease progression. HCC is a multifactorial disease and the investigation of progression of liver cirrhosis becomes much extensive with cultivating omics approaches. We have performed a comprehensive review about such challenges in multi-omics approaches that are concerned to identify the immunological, genetics and epidemiological factors associated with HCC. ( J CLIN EXP HEPATOL 2019;9:233-244)

Genome-Wide Transcriptional Analysis Reveals Alternative Splicing Event Profiles in Hepatocellular Carcinoma and Their Prognostic Significance

“…Then, the RNA-Seq data and corresponding clinicopathological information were mutually paired using the unique TCGA barcodes. Only patients who met the criteria listed below were included: ( Grandhi et al, 2016 ) patients with corresponding RNA-Seq data, ( Siegel et al, 2018 ) patients with complete clinicopathological information, including local invasion, tumor location, sex, age, distal metastasis, pathological stage, differentiation grade, lymph node metastasis, and survival information, ( Madduru et al, 2019 ) histological diagnosis of HCC, and ( Colecchia et al, 2014 ) survival for at least 1 month after the primary pathological diagnosis. SpliceSeq was used to determine RNA splicing patterns and produce AS profiles for each HCC patient as previously described ( Li Y. et al, 2017 ; Zhu et al, 2018 ).…”

“…Despite great advances in recent decades in screening, diagnosis, and curative surgery, hepatocellular carcinoma (HCC) remains the second leading cause of cancer-related mortality worldwide (Grandhi et al, 2016;Siegel et al, 2018). Epidemiological evidence has confirmed that the long-term outcomes of patients with HCC have not improved significantly with the rapid development of surgical techniques (Madduru et al, 2019). More importantly, because of the limitations of systematic status, tumor position, and the need to preserve liver function, more than 70% of patients are not eligible for surgical treatment.…”

Physicochemical characterization of a polysaccharide from Rosa roxburghii Tratt fruit and its antitumor activity by activating ROS mediated pathways

“…To date, multiple types of antineoplastic agents have been used to treat HCC, including sorafenib, nivolumab, lenvatinib, and regorafenib ( Anwanwan et al, 2020 ). However, these drugs are inadequate because of the hasty development of resistance and drug toxicity ( Madduru et al, 2019 ). In recent years, natural polysaccharides from plants, animals, fungi, bacteria, and algae have shown immense potential as they possess potential antitumor activities with low toxicity and side effects.…”