This chapter explores the dynamic interplay between systems and design thinking as essential methodologies for driving organizational change and innovation. It dives into the fundamental principles and practical implications of these approaches, highlighting their synergy and integration in addressing complex, multifaceted problems and changes. Organizations can foster a culture of continuous improvement and adaptability by integrating systems thinking's holistic view and design thinking's human-centred focus. Through examples, the chapter demonstrates how various sectors have successfully harnessed these approaches to innovate and transform. These insights will result in enhancing stakeholder engagement and decoding complexities and creating sustainable systemic solutions that align with organizational goals. This chapter is invaluable for leaders, managers, and change agents seeking to cultivate innovation and resilience in a complex, ever-evolving business landscape.