2024
DOI: 10.3390/ijms25105231
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Systems for Targeted Silencing of Gene Expression and Their Application in Plants and Animals

Daria M. Motorina,
Yuliya A. Galimova,
Nadezhda V. Battulina
et al.

Abstract: At present, there are a variety of different approaches to the targeted regulation of gene expression. However, most approaches are devoted to the activation of gene transcription, and the methods for gene silencing are much fewer in number. In this review, we describe the main systems used for the targeted suppression of gene expression (including RNA interference (RNAi), chimeric transcription factors, chimeric zinc finger proteins, transcription activator-like effectors (TALEs)-based repressors, optogenetic… Show more

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