2020
DOI: 10.1101/2020.06.24.168930
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Systems genetic analysis of binge-like eating in a C57BL/6J x DBA/2J-F2 cross

Abstract: Word count in abstract: 247 Word count in main text: 4410 ACKNOWLEDGEMENTS This work was funded by R21DA038738 (C.D.B.), R01DA039168 (C.D.B.), and R01CA221260 (M.I.D., C.D.B.) ABSTRACTObjective. Binge eating is a heritable quantitative trait associated with eating disorders (ED) and refers to the rapid consumption of a large quantity of energy-dense food that is associated with loss of control, anxiety, and depression. Binge Eating Disorder is the most common ED in adults in the US; however, the genetic basis … Show more

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Cited by 4 publications
(2 citation statements)
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“…Additionally, a recently developed genotyping array captures polymorphisms between inbred mouse substrains, facilitating rapid and reliable genotyping of RCCs (33). RCCs have been used successfully to identify genetic polymorphisms that impact psychostimulant response, binge eating, binge alcohol consumption, thermal nociception and brain weight (34)(35)(36)(37)(38).…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, a recently developed genotyping array captures polymorphisms between inbred mouse substrains, facilitating rapid and reliable genotyping of RCCs (33). RCCs have been used successfully to identify genetic polymorphisms that impact psychostimulant response, binge eating, binge alcohol consumption, thermal nociception and brain weight (34)(35)(36)(37)(38).…”
Section: Introductionmentioning
confidence: 99%
“…Mice remain the premier mammalian model organism for understanding the genetic and molecular mechanisms of complex traits that model aspects of complex diseases and disorders, permitting control over environmental variance, diet composition, and access to diet than in human studies and providing the molecular tools for validation. We previously described genetic elements mediating differences between the C57BL/6J and DBA/2J strains and mapped quantitative trait loci on chromosomes 5 and 11 responsible for initial palatable food intake and the escalation of palatable food consumption respectively (Babbs et al, 2018;Yao et al, 2021). Large phenotypic differences between closely related substrains, such as with C57BL/6 substrains (Kirkpatrick et al, 2017), can greatly facilitate genetic mapping and gene identification in an F2 reduced complexity cross (the generation and testing of a filial generation 2 population, produced by intercrossing of substrains) by reducing the density of genetic polymorphisms, reducing the chance of gene × gene interactions, and increasing the likelihood of identifying a single causal locus (Bryant et al, 2018(Bryant et al, , 2020.…”
Section: Introductionmentioning
confidence: 99%