Systems genetics view of endometriosis: a common complex disorder

Baranov, V. S.; Ivaschenko, T.; Liehr, Thomas; Yarmolinskaya, Maria I.

doi:10.1016/j.ejogrb.2014.11.036

Cited by 50 publications

(32 citation statements)

References 38 publications

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“…Candidate gene association studies, whole genome linkage analysis, as well as, more recent, genome-wide association studies (GWAS) were applied and resulted in the identification of over 100 candidate genes associated with EM [Baranov et al 2015]. Most were identified by functional mapping analysis with rather variable results.…”

Section: Gene Interactions: Emmentioning

confidence: 99%

“…Tentatively, it could be attributed either to implantation in peritoneum of otherwise normal cells of endometrum from menstrual debris or to metaplasia of preexisting undifferentiated epithelium cells from peritoneum [Baranov et al 2015;Signorilea and Baldia 2015]. Since 1991 it has been suggested that the high regenerative capacity of human endometrium is mediated by SCs [Padykula 1991].…”

Section: Origin Of Emmentioning

confidence: 99%

“…As follows from Figure 1, most of these genes are responsible for cell proliferation, control embryonic development, or are involved in tumorigenesis. Additional detail of the other candidate gene groups in EM pathogenesis is provided elsewhere [Baranov et al 2015].…”

Section: Gene Interactions: Emmentioning

confidence: 99%

“…Both are known as benign tumors of the female genital tract with EM stemming from cycling endometrium and UL from smooth muscle of the myometrium and have many traits in common (Table 1). Our recent review concerned new options using epigenetic approaches for understanding the development mechanisms and clinical manifestation peculiarities in EM [Baranov et al 2015].…”

Section: Introductionmentioning

confidence: 99%

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Comparative systems genetics view of endometriosis and uterine leiomyoma: Two sides of the same coin?

Baranov

Ivaschenko

Yarmolinskaya

2016

Systems Biology in Reproductive Medicine

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Endometriosis (EM) and uterine leiomyoma (UL) are two most frequent benign tumors of monoclonal origin affecting about 30% of all women in their reproductive age. Modern molecular technologies have made a tremendous impact in understanding both disorders. Here is the first comparative analysis of molecular mechanisms underlying development of EM and UL as it looks from the platform of systems genetics. Similarities and differences of EM and UL at their incipient stages are enlightened with special emphasis on their gene networks, gene expression, and epigenetic regulation, of pathologic development. The analysis substantiates a new hypothesis postulating tumors as outgrowths of the stem cells with mesenchymal commitment lineage (mSC) which migrate from the endometrium/myometrium junctional zone of the uterus. Comparative analysis has revealed basic similarities of molecular pathogenesis of EM and UL suggesting molecular syntropy of both disorders. Peculiarities of the epigenetic landscape determining development of mSC may explain the existence of different clinical forms of EM and UL as well as their unique clinical manifestation. Some perspectives for practical and scientific application in EM and UL studies of this new hypothesis are outlined.

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Section: Gene Interactions: Emmentioning

confidence: 99%

Section: Origin Of Emmentioning

confidence: 99%

Section: Gene Interactions: Emmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative systems genetics view of endometriosis and uterine leiomyoma: Two sides of the same coin?

Baranov

Ivaschenko

Yarmolinskaya

2016

Systems Biology in Reproductive Medicine

Self Cite

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show abstract

“…Экспрессия генов цитокинов и их рецепторов в норме претерпевает значительные циклические из-менения вместе с функциональным слоем эндоме-трия, так как находится под контролем гормональ-ной регуляции. В условиях нарушенного гормональ-ного статуса (абсолютной и относительной гипер-эстрогении), сдвигов в иммунной системе, циркули-рующих токсинов, источником которых является участок персистирующего воспаления в присутствии эктопически разросшейся патологической эндоме-триоидной ткани, физиологическая экспрессия дан-ных биологически активных веществ нарушается [19].…”

Section: характеристика рецептивности эндометрия у больных эндометриозомunclassified