This study proposes design science research (DSR) as a relevant framework for computational thinking, software engineering, and science, technology, engineering, arts and mathematics integration in higher education. We present four concrete case examples, where DSR has been applied in projects that consist of interdisciplinary teams, which learn by designing solutions for pressing real‐world problems. Our results show that DSR is a potent framework for learning to tackle pressing and wicked problems, and connecting technology projects with research methodology and knowledge from other fields. Our results also show multiple learning gains, including creativity, communication, critical thinking and collaboration. Based on our case analysis, we recommend more extensive use of DSR in future technology curricula.