Systems Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies

Bousquet, Jean; Jørgensen, Christian; Dauzat, M.; Cesario, Alfredo; Camuzat, T.; Bourret, Rodolphe; Best, Nicolas; Antó, Josep M.; Abécassis, Frédéric; Aubas, P; Avignon, A.; Badin, Mélanie; Bedbrook, Anna; Blain, Hubert; Bourdin, Arnaud; Bringer, J.; Camu, William; Cayla, Guilhaume; Costa, David J.; Courtet, Philippe; Cristol, Jean Paul; Demoly, Pascal; Coussaye, J.-E. de La; Fesler, Pierre; Gouzi, Farès; Gris, Jean‐Christophe; Guillot, B.; Hayot, Maurice; Jeandel, Claude; Jonquet, O.; Journot, Laurent; Lehmann, Sylvain; Mathieu, Gwenaelle; Morel, Jacques; Ninot, G.; Pélissier, J.; Picot, Marie Christine; Radier-Pontal, F.; Robine, Jean-Marie; Rodier, M.; Roubille, François; Sultan, Ariane; Wojtusciszyn, Anne; Auffray, Charles; Balling, Rudi; Bárbara, Cristina; Cambon‐Thomsen, Anne; Chavannes, Niels H.; Chuchalin, Alexander; Crooks, George; Dedeu, Antoni; Fabbri, Leonardo; Garcia‐Aymerich, Judith; Hajjam, Jawad; Gomes, Elisabete Melo; Palkonen, Susana; Piette, F.; Pison, Christophe; Price, David; Samoliński, Bolesław; Schünemann, Holger J.; Sterk, Peter J.; Yiallouros, Panayiotis Κ.; Roca, Josep; Perre, Philippe Van de; Mercier, Jacques

doi:10.2174/1381612820666140314115505

Cited by 61 publications

(49 citation statements)

References 138 publications

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“…The liver provides an appropriate starting tissue for multi-modal modelling (Virtual Liver Project) for these patients, as it is the organ responsible for the ultimate processing of most medications. The prevention and control of chronic diseases has been identified as a priority by a number of global institutions, and precision medicine approaches are being developed to improve the outcome and quality of life of patients with such diseases, both at the disease-specific and the comorbidity level [47].…”

Section: Precision Medicine Approachesmentioning

confidence: 99%

Problems, challenges and promises: perspectives on precision medicine

Duffy¹

2015

Brief Bioinform

110

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Conflicts of interest:The author discloses no potential conflicts of interest. Summary key points•Introduction of precision medicine/systems medicine concepts and approaches• Review of some of the challenges to the clinical implementation of precision medicine• Outline of methodologies being employed to overcome these challenges• Examination of the claims that precision medicine has overpromised Author biographyDavid J. Duffy is primarily an experimentalist, based at Systems Biology Ireland in University College Dublin. His research interests include cancer biology and evolutionary developmental biology and the application of omic technologies and systems medicine approaches to address questions in these fields. AbstractThe precision medicine (systems medicine) concept promises to achieve a shift to future

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Section: Precision Medicine Approachesmentioning

confidence: 99%

Problems, challenges and promises: perspectives on precision medicine

Duffy¹

2015

Brief Bioinform

110

View full text Add to dashboard Cite

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“…'Review response', including side-effects and patient satisfaction, is essential to avoid over-or under-treatment." This practical approach closely follows the paper presented to the World Health Organization on severe asthma in 2010 [28] and may be used for other chronic diseases [29]. Comparing COPD and asthma, this common approach to the severity and control of chronic diseases suggests important areas for research: prevention of asthma, treatment of severe asthma, and treatment of all patients with COPD [30].…”

Section: @Erspublicationsmentioning

confidence: 87%

GINA 2015: the latest iteration of a magnificent journey

Bousquet

Humbert

2015

Eur Respir J

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“…Many research teams worldwide adopted a bottom-up process, in an attempt to translate the systems biology approach into clinical practice. [23][24][25] Some envisaged a future model of Predictive, Preventive, Personalized and Participatory medicine (P4) based on the translation of systems biology, or as it has later become known, systems medicine. 26 While this approach holds the potential for huge impact, especially in relation to the discovery of new pharmaceutical compounds, in many cases there are knowledge gaps that make the clinical application difficult.…”

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confidence: 99%

In silico clinical trials: how computer simulation will transform the biomedical industry

2016

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<p class="abstract">The term ‘in silico clinical trials indicates the use of individualised computer simulation in the development or regulatory evaluation of a medicinal product, medical device, or medical intervention. This review article summarises the research and technological roadmap developed by the Avicenna Support Action during an 18 month consensus process that involved 577 international experts from academia, the biomedical industry, the simulation industry, the regulatory world, etc. The roadmap documents early examples of in silico clinical trials, identifies relevant use cases for in silico clinical trial technologies over the entire development and assessment cycle for both pharmaceuticals and medical devices, identifies open challenges and barriers to a wider adoption and puts forward 36 recommendations for all relevant stakeholders to consider<span lang="EN-US">.</span></p>

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Systems Medicine Approaches for the Definition of Complex Phenotypes in Chronic Diseases and Ageing. From Concept to Implementation and Policies

Cited by 61 publications

References 138 publications

Problems, challenges and promises: perspectives on precision medicine

Problems, challenges and promises: perspectives on precision medicine

GINA 2015: the latest iteration of a magnificent journey

In silico clinical trials: how computer simulation will transform the biomedical industry

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