Systems pharmacology dissection of action mechanisms for herbs in osteoporosis treatment

Huai, Ying; Zhang, Wenjuan; Wang, Wei; Dang, Kai; Jiang, Shuai; Li, Dan-ming; Li, Meng; Hao, Qiang; Miao, Zhiping; Liu, Yü; Qian, Airong

doi:10.1016/j.chmed.2021.06.001

Cited by 6 publications

(4 citation statements)

References 128 publications

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“…25 Furthermore, the inflammatory milieu created by consuming a pro-inflammatory diet may disrupt the delicate balance between bone formation and resorption. 26 This dysregulation could impede the function of osteoblasts, the cells responsible for bone formation, ultimately compromising bone strength and quality. 27 Additionally, pro-inflammatory diets are often associated with comorbidities such as obesity, diabetes, and cardiovascular diseases, which themselves can impact bone health and fracture risk.…”

Section: Discussionmentioning

confidence: 99%

Association between the Dietary Inflammatory Index and fracture risk in older adults: a systematic review and meta-analysis

Zheng,

Li,

Yan

et al. 2024

J Int Med Res

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Objective We explored correlations between the Dietary Inflammatory Index (DII) and fracture risk in older adults. Methods We systematically searched MEDLINE, PubMed, Science Direct, Scopus, and CNKI for all relevant epidemiological studies published through October 16, 2023. Because observational studies were included in the meta-analysis, we used a random-effects model to pool the study-specific effect sizes and 95% confidence intervals (CIs). We assessed study quality using the Newcastle–Ottawa scale. This meta-analysis was registered in PROSPERO. Results Eight studies with 462,986 participants were included, with five cohort studies, two cross-sectional studies, and one case–control study. An analysis of heterogeneity among the eight included studies resulted in I2 = 87.1%, indicating significant between-study heterogeneity; hence, the random-effects model was adopted to generate the combined effect size. We found that the DII was positively associated with fracture (relative risk: 1.188, 95% CI: 1.043–1.354). This result was further confirmed in leave-one-out sensitivity analysis. Conclusions Our study provides evidence suggesting that diets high in pro-inflammatory components might increase the fracture risk among older people. Decreased consumption of pro-inflammatory foods and increased consumption of anti-inflammatory foods are suggested to prevent adverse fracture outcomes. More prospective studies involving both sexes are warranted to verify the results.

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Section: Discussionmentioning

confidence: 99%

Association between the Dietary Inflammatory Index and fracture risk in older adults: a systematic review and meta-analysis

Zheng,

Li,

Yan

et al. 2024

J Int Med Res

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“…ALP, Runt-related transcription factor 2 (RUNX2), and collagen type I α 1 chain (COL Iα1) are hallmark genes of osteogenic differentiation ( Komori, 2010 ; Mostofi et al, 2022 ). With the MC3T3-E1 mouse osteoblast cell line, Huai and coworkers revealed that HG displayed an anti-osteoporosis effect based on facilitating the differentiation and proliferation of osteoblasts via upregulating the expression of the above osteoblast differentiation-related characteristic genes ( Huai et al, 2021 ).…”

Section: Effects and Mechanisms Of Hg And Its Derivativesmentioning

confidence: 99%

“…As evidenced by numerous research articles, HG and its derivatives exhibit a wide spectrum of pharmacological activities in vitro and in vivo , such as anti-cancer ( Liu B. X. et al, 2014 ), anti-inflammation ( Lee et al, 2015 ), anti-neurodegeneration ( Wu et al, 2017 ), anti-depression ( Zhou et al, 2010 ), anti-hyperglycemia ( Luo et al, 2008 ), anti-hyperlipidemia ( Lu et al, 2015 ), and anti-pathogen activities ( Rodríguez-Hernández et al, 2016a ). Recently, the novel pharmacological effects are constantly being discovered, such as anti-fibrosis effect ( Ma et al, 2020 ; Yang and He, 2022 ) and anti-osteoporosis effect ( Tian et al, 2020 ; Huai et al, 2021 ). In addition, more and more neoteric target genes and signaling pathways through which HG and its derivatives exert their effects have been experimentally validated.…”

Section: Introductionmentioning

confidence: 99%

An updated review of the pharmacological effects and potential mechanisms of hederagenin and its derivatives

Zhang,

Li,

Liu

2024

Front. Pharmacol.

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Hederagenin (HG) is a natural pentacyclic triterpenoid that can be isolated from various medicinal herbs. By modifying the structure of HG, multiple derivatives with superior biological activities and safety profiles have been designed and synthesized. Accumulating evidence has demonstrated that HG and its derivatives display multiple pharmacological activities against cancers, inflammatory diseases, infectious diseases, metabolic diseases, fibrotic diseases, cerebrovascular and neurodegenerative diseases, and depression. Previous studies have confirmed that HG and its derivatives combat cancer by exerting cytotoxicity, inhibiting proliferation, inducing apoptosis, modulating autophagy, and reversing chemotherapy resistance in cancer cells, and the action targets involved mainly include STAT3, Aurora B, KIF7, PI3K/AKT, NF-κB, Nrf2/ARE, Drp1, and P-gp. In addition, HG and its derivatives antagonize inflammation through inhibiting the production and release of pro-inflammatory cytokines and inflammatory mediators by regulating inflammation-related pathways and targets, such as NF-κB, MAPK, JAK2/STAT3, Keap1-Nrf2/HO-1, and LncRNA A33/Axin2/β-catenin. Moreover, anti-pathogen, anti-metabolic disorder, anti-fibrosis, neuroprotection, and anti-depression mechanisms of HG and its derivatives have been partially elucidated. The diverse pharmacological properties of HG and its derivatives hold significant implications for future research and development of new drugs derived from HG, which can lead to improved effectiveness and safety profiles.

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“…Chinese herbal medicines were used to treat bone diseases and improve bone quality by regulating the dynamic balance between bone formation and bone resorption. Studies showed that Chinese herbal medicines used to treat osteoporosis usually promote the bone formation of osteoblasts and inhibit the bone resorption process of osteoclasts, thus effectively alleviating the symptoms of osteoporosis by maintaining the balance of bone metabolism ( He et al, 2019 ; Huai et al, 2021 ). However, few studies have been done on the application of Chinese herbal medicines in domestic chickens.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomics reveals the molecular regulation of Chinese medicine formula on improving bone quality in broiler

Zhao,

Duan,

Yan

et al. 2023

Poultry Science

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Systems pharmacology dissection of action mechanisms for herbs in osteoporosis treatment

Cited by 6 publications

References 128 publications

Association between the Dietary Inflammatory Index and fracture risk in older adults: a systematic review and meta-analysis

Association between the Dietary Inflammatory Index and fracture risk in older adults: a systematic review and meta-analysis

An updated review of the pharmacological effects and potential mechanisms of hederagenin and its derivatives

Transcriptomics reveals the molecular regulation of Chinese medicine formula on improving bone quality in broiler

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