Systems pharmacology reveals the multi-level synergetic mechanism of action of Ginkgo biloba L. leaves for cardiomyopathy treatment

Liu, Yueping; Xu, Chi; Wang, Haiqing; Liu, Xiaobing; Jiang, Li; Liang, Shengnan; Wu, Ziyin; Wang, Zhenzhong; Zhou, Jun; Xiao, Wei; Guo, Zihu; Wang, Yonghua

doi:10.1016/j.jep.2020.113279

Cited by 19 publications

(19 citation statements)

References 52 publications

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“…The extracts of G. biloba contain Ginkgolide B, flavonoid-O-glycosides and terpene trilactone which controls H2O2/FeSO4-induced oxidative damage ( Shi et al, 2010 ). It also reduces intracellular ROS generation by preventing amyloid peptide (A)-induced mitochondrial dysfunction and thereby accumulation of the Aβ fibrils which is a potent neurotoxin ( Li et al, 2021 ). Ion homeostasis, modification of tau protein phosphorylation, and activation of growth factor production are all possible pathways for G. biloba extract’s neuroprotective effects ( Singh et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Phytotherapy for Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis

et al. 2022

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Attention deficit hyperactivity disorder (ADHD) is commonly a neurodevelopmental behavioural disorder in children and adolescents. Mainly characterized by symptoms like lack of attention, hyperactivity, and impulsiveness, it can impact the overall mental development of the one affected. Several factors, both genetic and non-genetic, can be responsible for this disorder. Although several traditional treatment methods involve medication and other counselling techniques, they also come with different side effects. Hence, the choice is now shifting to alternative treatment techniques. Herbal treatments are considered one of the most popular complementary and alternative medicine (CAM) administered. However, issues related to the safety and efficacy of herbal remedies for the treatment of ADHD need to be investigated further. This study aims to find out the recent advancement in evidence-based use of herbal remedies for ADHD by a comprehensive and systematic review that depicts the results of the published works on herbal therapy for the disorder. The electronic databases and the references retrieved from the included studies present related randomized controlled trials (RCTs) and open-label studies. Seven RCTs involving children and adolescents diagnosed with ADHD met the inclusion criteria. There is a fair indication of the efficacy and safety of Melissa officinalis L., Bacopa monnieri (L.) Wettst., Matricaria chamomilla L., and Valeriana officinalis L. from the studies evaluated in this systematic review for the treatment of various symptoms of ADHD. Limited evidence was found for Ginkgo biloba L. and pine bark extract. However, various other preparations from other plants did not show significant efficacy. There is inadequate proof to strongly support and recommend the administration of herbal medicines for ADHD, but more research is needed in the relevant field to popularize the alternative treatment approach.

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Section: Resultsmentioning

confidence: 99%

Phytotherapy for Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis

et al. 2022

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“…However, the healing is often “stalled” in the inflammation phase, which is mainly caused by an elevated production of pro-inflammatory mediators within the diabetic wounds ( Salazar et al, 2016 ). GB ( Figure 1A ), a natural product extracted from the leaves of Ginkgo biloba L. , exerts the anti-inflammatory activity in protecting against inflammation-associated disorders (e.g., stroke and cardiomyopathy) ( Shu et al, 2016 ) ( Li et al, 2021a ). In this study, the anti-inflammatory effects of GB were assessed ex vivo using LPS and IFN-γ co-stimulated BMDM ( Figures 1B,C ).…”

Section: Resultsmentioning

confidence: 99%

Local Administration of Ginkgolide B Using a Hyaluronan-Based Hydrogel Improves Wound Healing in Diabetic Mice

Wang¹,

Xia²,

Han³

et al. 2022

Front. Bioeng. Biotechnol.

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“…ISO was found to reverse the enhanced TGF- β and collagen type I alpha 1 mRNA expression induced by AgII exposure, which causes cardiovascular remodeling in ventricular tissue [ 27 ]. Isorhamnetin treated myocardial-related diseases by regulating PI3K, Akt, and NF- κ B signaling pathway [ 28 ]. Components of Tinglizi, such as quercetin, kaempferol, β -sitosterol, and isorhamnetin, collectively resist inflammation and oxidative stress, protect cardiomyocytes, and inhibit ventricular remodeling to treat CHF.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Mechanisms of Tinglizi against Chronic Heart Failure Determined by Network Pharmacology and Molecular Docking

Luo

Wang

Huang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Tinglizi has been extensively used to treat chronic heart failure (CHF) in modern times, but the material basis and pharmacological mechanisms are still unclear. To explore the material basis and corresponding potential targets and to elucidate the mechanism of Tinglizi, network pharmacology and molecular docking methods were utilized. Methods. The main chemical compounds and potential targets of Tinglizi were collected from the pharmacological database analysis platform (TCMSP). The corresponding genes of related action targets were queried through gene cards and UniProt database. The corresponding genes of CHF-related targets were searched through Disgenet database, and the intersection targets were obtained by drawing Venn map with the target genes related to pharmacodynamic components. Then, drug targets and disease targets were intersected and put into STRING database to establish a protein interaction network. The “active ingredient-CHF target” network was constructed with Cytoscape 3.8.2. Finally, Gene Ontology (GO) Enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of intersection targets were analyzed using metascape. With the aid of SYBYL software, the key active ingredients and core targets were docked at molecular level, and the results were visualized by PyMOL software. Molecular docking was carried out to investigate interactions between active compounds and potential targets. Results. A total of 12 active components in Tinglizi were chosen from the TCMSP database, and 193 corresponding targets were predicted. Twenty-nine potential targets of Tinglizi on CHF were obtained, of which nine were the core targets of this study. Twenty GO items were obtained by GO function enrichment analysis ( P < 0.05 ), and 10 signal pathways were screened by KEGG pathway enrichment analysis ( P < 0.05 ), which is closely related to the treatment of CHF by Tinglizi. The constructed drug compound composition action target disease network shows that quercetin, kaempferol, and other active compounds play a key role in the whole network. The results of molecular docking showed that all the key active ingredients, such as quercetin and isorhamnetin, were able to successfully dock with ADRB2 and HMOX1 with a total score above 5.0, suggesting that these key components have a strong binding force with the targets. Conclusion. Through network pharmacology and molecular docking technology, we found that the main components of Tinglizi in the treatment of CHF are quercetin, kaempferol, β-sitosterol, isorhamnetin, and so on. The action targets are beta 2-adrenergic receptor (ADRB2), heme oxygenase 1 (HMOX1), and so on. The main pathways are advanced glycation end products/receptor for advanced glycation end products (AGE-RAGE) signaling pathway in diabetic complications, hypoxia-inducible factor (HIF-1) signaling pathway, estrogen signaling pathway, and so on. They play an integrated role in the treatment of CHF.

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Systems pharmacology reveals the multi-level synergetic mechanism of action of Ginkgo biloba L. leaves for cardiomyopathy treatment

Cited by 19 publications

References 52 publications

Phytotherapy for Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis

Phytotherapy for Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis

Local Administration of Ginkgolide B Using a Hyaluronan-Based Hydrogel Improves Wound Healing in Diabetic Mice

Pharmacological Mechanisms of Tinglizi against Chronic Heart Failure Determined by Network Pharmacology and Molecular Docking

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