Systolic blood pressure, heart rate, and outcomes in patients with coronary disease and heart failure

Elgendy, Islam Y.; Hill, James A.; Szady, Anita; Gong, Yan; Cooper‐DeHoff, Rhonda M.; Pepine, Carl J.

doi:10.1002/ehf2.12534

Cited by 4 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated that hypertensive patients with persistent HR ≥ 80 bpm have a higher risk of all-cause and CV death than those with HR < 80 bpm [ 31 ]. Elgendy et al found that in CAD patients with hypertension and a history of heart failure, achieving systolic blood pressure of 120–140 mmHg and HR < 85 bpm was associated with a better prognosis [ 32 ]. These results may suggest combined effects of HR and hypertension on CV morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

Effect of Presence versus Absence of Hypertension on Admission Heart Rate-Associated Cardiovascular Risk in Patients with Acute Coronary Syndrome

Xia

Wang

Gao

et al. 2022

International Journal of Hypertension

View full text Add to dashboard Cite

Background and Aims. Heart rate (HR) and hypertension are both important risk factors for adverse cardiovascular (CV) events in patients with established coronary artery disease (CAD). We sought to evaluate whether hypertension can modify the effect of admission HR on adverse CV events in patients with acute coronary syndrome (ACS). Methods. A total of 1056 patients with ACS undergoing percutaneous coronary intervention (PCI) were analyzed. All patients were classified into three groups according to the tertiles of admission HR (T1: ≤66 bpm, n = 369; T2: 67–73 bpm, n = 322; and T3: ≥74 bpm, n = 365). The primary endpoint was defined as major adverse CV events (MACEs), including all-cause death, stroke, myocardial infarction, or unplanned repeat revascularization. The multivariate Cox regression model was performed to evaluate the association of admission HR with MACE stratified by hypertension. Results. During the median follow-up of 30 months, a total of 232 patients developed at least one event. After adjusting for other covariates, elevated admission HR was significantly associated with an increased risk of MACE only in patients with hypertension (when T1 was taken as a reference, the adjusted HR of T2 was 1.143 [95% CI: 0.700–1.864] and that of T3 was 2.062 [95% CI: 1.300–3.270]); however, in patients without hypertension, admission HR was not associated with the risk of MACE (when T1 was taken as a reference, the adjusted HR of T2 was 0.744 [0.406–1.364] and that of T3 was 0.614 [0.342–1.101]) ( P = 0.025 for interaction). Conclusions. In patients with ACS undergoing PCI, the association of elevated admission HR with an increased risk of MACE was present in individuals with hypertension but not in those without hypertension. This finding suggests a potential benefit of HR control for ACS patients when they concomitantly have hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Presence versus Absence of Hypertension on Admission Heart Rate-Associated Cardiovascular Risk in Patients with Acute Coronary Syndrome

Xia

Wang

Gao

et al. 2022

International Journal of Hypertension

View full text Add to dashboard Cite

show abstract

“…In terms of the frequency of research hotspots, diabetes, obesity, and hypertension are signi cant risk factors of post-MI HF [52][53][54], exhibiting a high research heat. Simultaneously, factors like patients' age, atrial brillation, COPD, kidney injury, smoking, and sleep are closely associated with the onset of this disease [5,[55][56][57][58].…”

Section: Risk Factors Of Post-mi Hfmentioning

confidence: 99%

Research status and development trends of post-myocardial infarction heart failure: a bibliometric analysis from 2012 to 2022

Hou,

Wang,

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective: Post-myocardial infarction heart failure (post-MI HF) is a prevalent cardiovascular disease. The study aims to preliminarily explore the current research status and development trends in the field of post-MI HF, providing reference ideas and methods for clinical and scientific research. Methods: Publications related to post-MI HF from 2012-2022 in the Web of Science Core Collection's SCI-expanded dataset were extracted. Bibliometric analysis was executed using VOSviewer and R-bibliometrix, encompassing the number of publications, countries, institutions, authors, journals, cited references, and keywords. Results: Within the last decade, 10,929 publications in the domain were published, involving 58,357 authors from 10,437 research institutions across 120 different countries and regions. These findings appeared in 1,446 distinct journals. The United States led in the number of publications, with Harvard Medical School being the most active institution and Kober, Lars from the University of Copenhagen, Denmark, as the leading author. Plos One was the most prolific journal, while Circulationhad the highest citation count. Over the past decade, research hotspots mainly centered on mortality, cardiac remodeling, and prognosis. In the recent two years, emphasis shifted to topics such as mendelian randomization, dapagliflozin, sacubitril/valsartan, COVID-19, and machine learning. Conclusion: The study reveals the overall performance of publications in the post-MI HF research field. The clinical prognosis of patients and cardiac remodeling have been research hotspots over the past decade, yet mortality and readmission remain urgent clinical challenges. Future research trends in this field may revolve around the mechanisms of cardiac remodeling, apoptosis, and inflammation, as well as clinical prognosis studies on patient mortality rates. Additionally, echocardiography and cardiac magnetic resonance technology are gradually becoming important methods for evaluating drug efficacy and elucidating related mechanisms.

show abstract

“…Blood pressure (BP) and heart rate (HR) are fundamental vital signs that can be assessed during emergency ambulance transport or upon hospital admission, as necessary. Prior studies have indicated that fluctuations in blood pressure and heart rate, along with impaired baroreflex sensitivity (primarily indicative of autonomic dysregulation), are correlated with poor outcomes in ischemic stroke and other cardiovascular diseases [ 5 , 6 ]. While previous research on autonomic function in the context of acute ICH is limited, our study aims to elucidate the relationship between blood pressure, heart rate, and the severity and prognosis of patients with ICH.…”

Section: Introductionmentioning

confidence: 99%

Association of severity and prognosis with elevated blood pressure and heart rate levels in patients with intracerebral hemorrhage

Wang,

Jiang,

Kang

et al. 2023

BMC Neurol

View full text Add to dashboard Cite

Background Intracerebral hemorrhage (ICH) has a high mortality and morbidity in the world. Elevated blood pressure (BP) and heart rate (HR) have been identified as independent risk factors, with potential to predict prognosis and recurrence of cardiovascular diseases. Our study aimed to elucidate the association between BP and HR levels and the severity, as well as prognosis, of patients diagnosed with ICH. Methods The basic characteristics of patients and laboratory examination results, inclusive of BP and HR levels upon admission, were recorded as baseline data. The modified Rankin Scale and living status were taken into account for all patients at a 1-year follow-up. The relationship between various BP and HR levels and clinical outcome was analyzed using logistic regression and the Kaplan-Meier survival method. Results A total of 1,416 patients with acute ICH from 13 hospitals in Beijing were enrolled in our study. Logistic regression analysis indicated that patients with higher HR and BP (group 4), along with those with higher HR but lower BP (group 2), exhibited a poorer prognosis compared to those with lower BP and HR (group 1). This result was particularly pronounced in younger, male subgroups (OR (95% CI) = 4.379(2.946–6.508), P < 0.0001 for group 4; OR (95% CI) = 1.819 (1.219–2.714), P = 0.0034 for group 2). At the 1-year follow-up, group 4 patients demonstrated a significantly higher rate of fatal incidence compared to other groups (P < 0.01). Conclusions Higher HR and BP levels, suggestive of an autonomic dysfunction, were independently associated with a poorer 1-year prognosis and reduced survival rate in ICH patients. Our findings underscore the need for early intervention to modulate these physiological parameters in patients with ICH.

show abstract

Systolic blood pressure, heart rate, and outcomes in patients with coronary disease and heart failure

Cited by 4 publications

References 28 publications

Effect of Presence versus Absence of Hypertension on Admission Heart Rate-Associated Cardiovascular Risk in Patients with Acute Coronary Syndrome

Effect of Presence versus Absence of Hypertension on Admission Heart Rate-Associated Cardiovascular Risk in Patients with Acute Coronary Syndrome

Research status and development trends of post-myocardial infarction heart failure: a bibliometric analysis from 2012 to 2022

Association of severity and prognosis with elevated blood pressure and heart rate levels in patients with intracerebral hemorrhage

Contact Info

Product

Resources

About