Systolic longitudinal global and segmental myocardial mechanics in symptomatic isolated left ventricular non‐compaction cardiomyopathy

Bogunović, Nikola; Farr, Martin; Pirl, Lukas; Faber, Lothar; Buuren, Frank van; Rudolph, Volker; Roder, Fabian

doi:10.1111/echo.15014

Cited by 2 publications

(16 citation statements)

References 41 publications

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“…1 – 4 , a + c). In healthy individuals and patients with LV-NC [ 21 ], peak longitudinal systolic strain was lowest antero-septally (Fig. 1 a), whereas in CAM, a circumferential shift was detected with lowest values posteriorly and highest antero-septally.…”

Section: Resultsmentioning

confidence: 99%

“…Besides standard echocardiographical parameters, mappings of the longitudinal myocardial mechanics of the entire LV were created for each of the STE-derived parameters and groups using a 17-segment polar diagram [ 23 ]. All parameters in individuals with CAM were compared with those with LV-NC and normal hearts from a previous study conducted at our institution [ 21 ]. Additionally, significant differences between values in AL-CAM and ATTR-CAM were evaluated.…”

Section: Methodsmentioning

confidence: 99%

“…We compared the data in CAM with 30 patients with symptomatic isolated LV-NC (males/females 17/13, mean age 49.4 ± 17.4, range 21–81 years) [ 21 ]. The control group included 150 carefully selected individuals with healthy heart (75 males, 75 females, mean age 33.8 ± 11.5, range 16–76 years) who presented a normal ECG, normal exercise tolerance, normal clinical findings, and a normal echocardiogram [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…A 17-segment polar diagram with mean segmental values for each parameter [ 20 , 21 , 23 ] and group (i.e. healthy, CAM, LV-NC) was used to obtain an overview of the myocardial mechanics for the entire LV.…”

Section: Methodsmentioning

confidence: 99%

“…Although hypertrophic cardiomyopathy (HCM) is more often in the differential diagnosis of CAM, both systolic and diastolic dysfunction are not universally present in patients suffering from HCM and comparison of strain analyses in CAM versus HCM is reported before [ 25 ]. Therefore, we used the data from a previous study conducted at our institution [ 21 ] of patients with symptomatic isolated LV-NC. The patients with LV-NC complied with the preconditions (i.e.…”

Section: Aim Of the Studymentioning

confidence: 99%

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Multi-parametric speckle tracking analyses to characterize cardiac amyloidosis: a comparative study of systolic left ventricular longitudinal myocardial mechanics

Bogunović

Farr

Pirl³

et al. 2022

Heart Vessels

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Cardiac amyloidosis (CAM), the most common cardiac storage disease is associated with significant changes in left-ventricular (LV) morphology and function. To gain particular insights into LV systolic longitudinal myocardial mechanics we investigated seven parameters derived by speckle-tracking-echocardiography (STE) in patients with confirmed CAM (n = 59). The results were compared with those of individuals with healthy heart (n = 150) and another primary myocardial disease with also thickened myocardium and severe diastolic and systolic LV-dysfunction (symptomatic LV-non-compaction-cardiomyopathy, LV-NC, n = 30). In addition to standard echocardiographical measures, the STE-derived data were evaluated and documented utilizing polar-diagrams to obtain overviews of longitudinal myocardial mechanics of the entire LV. Compared with healthy individuals, patients with CAM and LV-NC showed significantly reduced LV-ejection-fraction (EF), global longitudinal systolic peak-strain, strain-rate, and displacement. Pre-systolic stretch-index, post-systolic index, and the EF/global peak-longitudinal-strain-ratio (EF/S) were increased. In contrast to healthy-hearts and the LV-NC group only patients with CAM demonstrated significantly reduced time-to-peak systolic longitudinal strain and time-to-peak strain-rate. Although the level of the segmental values in longitudinal mechanics was significantly different between the groups, comparable intraventricular baso-apical parameter-gradients were found for systolic longitudinal peak-strain and strain-rate, pre-systolic-stretch-index, post-systolic-index, and peak systolic displacement. Compared to ATTR-amyloidosis (ATTR-CAM), patients with AL-amyloidosis (AL-CAM) demonstrated significantly lower end-diastolic and end-systolic LV-volumes, LV-mass-indices, relative apical strain, time-to-peak systolic longitudinal strain, and time-to-peak longitudinal strain-rate. CAM and LV-NC demonstrated altered myocardial mechanics with significantly different STE-derived echocardiographical parameters. ATTR-amyloidosis and AL-amyloidosis had at least significantly different time-to-peak strain, time-to-peak strain-rate and relative apical sparing values.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Aim Of the Studymentioning

confidence: 99%

See 3 more Smart Citations

Multi-parametric speckle tracking analyses to characterize cardiac amyloidosis: a comparative study of systolic left ventricular longitudinal myocardial mechanics

Bogunović

Farr

Pirl³

et al. 2022

Heart Vessels

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Myocardial Mechanics and Associated Valvular and Vascular Abnormalities in Left Ventricular Noncompaction Cardiomyopathy

Nemes

2023

JCM

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Left ventricular (LV) non-compaction (LVNC) is a rare genetic cardiomyopathy due to abnormal intra-uterine arrest of compaction of the myocardial fibers during endomyocardial embryogenesis. Due to the partial or complete absence of LV compaction, the structure of the LV wall shows characteristic abnormalities, including a thin compacted epicardium and a thick non-compacted endocardium with prominent trabeculations and deep intertrabecular recesses. LVNC is frequently associated with chronic heart failure, life-threatening ventricular arrhythmias, and systemic embolic events. According to recent findings, in the presence of LVNC, dysfunctional LV proved to be associated with left atrial volumetric and functional abnormalities and consequential dilated and functionally impaired mitral annulus, partly explaining the higher prevalence of regurgitation. Although the non-compaction process morphologically affects only the LV, signs of remodeling of the right heart were also detected. Moreover, dilation and stiffening of the aorta were present. The aim of the present detailed review was to summarize findings regarding changes in cardiac mechanics, valvular abnormalities, and vascular remodeling detected in patients with LVNC.

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Systolic longitudinal global and segmental myocardial mechanics in symptomatic isolated left ventricular non‐compaction cardiomyopathy

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 2 publications

References 41 publications

Multi-parametric speckle tracking analyses to characterize cardiac amyloidosis: a comparative study of systolic left ventricular longitudinal myocardial mechanics

Multi-parametric speckle tracking analyses to characterize cardiac amyloidosis: a comparative study of systolic left ventricular longitudinal myocardial mechanics

Myocardial Mechanics and Associated Valvular and Vascular Abnormalities in Left Ventricular Noncompaction Cardiomyopathy

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