Systolic Time Intervals in Heart Failure in Man

Weissler, Arnold M.; Harris, Willard S.; Schoenfeld, Clyde D.

doi:10.1161/01.cir.37.2.149

Cited by 1,186 publications

(574 citation statements)

References 18 publications

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“…The phases of systole were measured in 51 patients with acute myocardial infarction and three control groups: (1) a group of 40 patients without heart disease, (2) …”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Preejection Period and Ejection Time in Patients with Acute Myocardial Infarction

et al. 1972

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“…The phases of systole were measured in 51 patients with acute myocardial infarction and three control groups: (1) a group of 40 patients without heart disease, (2) …”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Preejection Period and Ejection Time in Patients with Acute Myocardial Infarction

et al. 1972

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“…MAP was calculated by (SBP + 2 Â DBP)/ 3. In a separate adjustment step, we checked whether results were further influenced by taking individual differences in HR (extracted from the ECG inter-beat-interval time series) and MAP into account (Weissler et al, 1968;Wolf et al, 1978). Finally, in order to examine whether severity of symptomatology further impacted on found associations, analyses were additionally corrected for depression and anxiety severity using the IDS and BAI scores (Rush et al, 1996;Steer et al, 1995).…”

Section: Measurementsmentioning

confidence: 99%

Effects of Antidepressants, but not Psychopathology, on Cardiac Sympathetic Control: A Longitudinal Study

Licht

Penninx

Geus³

2012

Neuropsychopharmacol

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Increased sympathetic activity has been hypothesized to have a role in the elevated somatic disease risk in persons with depressive or anxiety disorders. However, it remains unclear whether increased sympathetic activity reflects a direct effect of anxiety or depression or an indirect effect of antidepressant medication. The aim of this study was to test longitudinally whether cardiac sympathetic control, measured by pre-ejection period (PEP), was increased by depression/anxiety status and by antidepressant use. Cross-sectional and longitudinal data were from a depression and anxiety cohort: the Netherlands Study of Depression and Anxiety (NESDA). Baseline data of 2838 NESDA subjects (mean age 41.7 years, 66.7% female) and 2-year follow-up data of 2226 subjects were available for analyses. Included were subjects with and without depressive/anxiety disorders, using or not using different antidepressants at baseline or followup. The PEP was measured non-invasively by 1.5 h of ambulatory impedance cardiography. Cross-sectional analyses compared PEP across psychopathology and antidepressant groups. Longitudinal analyses compared 2-year changes in PEP in relation to changes in psychopathology and antidepressant use. Cross-sectional analyses showed that antidepressant-naïve depressive/anxious subjects had comparable PEP as controls, whereas subjects using tricyclic (TCA) or combined serotonergic/noradrenergic antidepressants (SNRI) had significantly shorter PEP compared with controls. In contrast, subjects using selective serotonin re-uptake inhibitors (SSRIs) had longer PEP than controls. Longitudinal results confirmed these findings: compared with 2-year change in PEP in continuous non-users ( + 2 ms), subjects who started TCA or SNRI treatment showed significantly shortened PEP (À11 ms, p ¼ 0.005 and po0.001), whereas subjects who started SSRI treatment showed significant prolongation of PEP ( + 9 ms, p ¼ 0.002). Reversed findings were observed among those who stopped antidepressant use. These findings suggest that depressive and anxiety disorders are not associated with increased cardiac sympathetic control. However, results pose that TCA and SNRI use increases sympathetic control, whereas SSRI use decreases sympathetic control.

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“…Is The PEP and LVET are automatically and continuously measured and indexed to H R according to Weissler's tbrmula, 14 The PEP/LVET ratio is also calculated automatically. These values are presented in table form and updated every eight seconds on a screen display.…”

Section: Probe and Flowmetermentioning

confidence: 99%

Continuous oesophageal aortic blood flow echo-Doppler measurement during general anaesthesia in infants

et al. 1997

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Purpose: Invasive haemodynamic monitoring dunng general anaesthesia in infants is usually hmited to very high nsk operations, such as cardiac surgery. Nevertheless, different surgical procedures and/or anaesthetic techniques justify additional monrtonng for children, as for adults. The aim of this preliminary study was to evaluate the feasibility of using a new echo-Doppler device (Dynemo 3000| capable of measunng continuous aortic blood flow during general anaesthesia in infants. Methods: Aortic blood flow (ABF) was measured with a small oesophageal probe designed for newboms and infants. The aortic flowmeter was connected with satellite devices to visualise the haemodynamic profile which included ABE pre-ejection period (PEPi), left ventricular election time (LVETi), mean arterial pressure, heart rate, stroke volume and systemic vascular resistance. Twelve infants, aged 8-26 mo, undergoing surgery under general anaesthesia were successively included in the evaluation of this device. Isoflurane (1% end-expired concentration) was introduced to maint~n anaesthesia after induction with halothane, midazolam, fentanyl and atracurium. Results: Correct positioning of the probe was easily obtained in all cases and the recording quality was excellent, whatever the operative position. Recordings of haemodynamic data showed some myocardial depression from isoflurane: decreased ABF (indexed to body surface area) and lengthened PEP/LVET (2.24 + 0.53 L.min '-m ~ and 0.32 -+ 0.05 respectively, before introduction of isoflurane and 1.71 + 0.53 L.min ~.m ~ (P = 0.027) and 0.39 *_ 0.06 (P --0.007) with isoflurane). Condusiom These preliminary results suggest that this continuous ABF echo-Doppler device may be valuable for peri anaesthetic monitoring in infants.Objectif : La surveillance per-anesth6sique de la fonction cardiovasculaire par methode invasive est exceptionnelle chez les nourrissons, et se limite g~n6ralement ~ des indications chirur~cales & tr& haut risque, telle que la chirurgie cardiaque. Pourtant, diff&entes situations per-op&atoires et/ou anesth6siques justifiereent parfols une surveillance renforc6e chez le nournsson, comme chez I'adulte. Le but de cette &ude pr~liminalre est d'6valuer la faisabilit6 d'une nouvelle m6thode de mesure continue du d6bit aortique (DA) au cour~ de I'anesth6sie g6n6rale des noumssons. M&hodes : Un d~bitrn&re aortique (Dynamo 3000| permet g~ce ~ une sonde oesophagienne pediatnque &ho-Doppler de petit calibre, de d&erminer en continu le DA, le volume d'~jection systolique, les r&istances vasculaires syst~miques et les p&iodes de pr6-~jection (PEPi) et d'~jection du ventncule gauche (LVETi). Douze enfants, de 8 ~ 26 mois, subissant une intervention chirurgicale sous anesth6sie g6ne,-ale ont 6t6 successivement inclus. l'induction anesthesique a 6t6 r6alis6e par halothane, midazolam, fentanyl et atracunum et I'entretien par isoflurane (fraction t~l~expiratoire = I%). R~stdtats : La mise en place de la sonde oesophagienne &ho-Doppler a 6te asee dans tous les cas. Les enregistrements simult...

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Systolic Time Intervals in Heart Failure in Man

Cited by 1,186 publications

References 18 publications

Left Ventricular Preejection Period and Ejection Time in Patients with Acute Myocardial Infarction

Left Ventricular Preejection Period and Ejection Time in Patients with Acute Myocardial Infarction

Effects of Antidepressants, but not Psychopathology, on Cardiac Sympathetic Control: A Longitudinal Study

Continuous oesophageal aortic blood flow echo-Doppler measurement during general anaesthesia in infants

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