Szuperparamágneses vas-oxid nanorészecskék (SPIONs)teranosztikai célú fejlesztése

Multifunctional PEG-carboxylate copolymer coated superparamagnetic iron oxide nanoparticles for biomedical application

“…Both results show in fact negative growth inhibition revealing that the MNP fluid did not reduce cell proliferation. Similar negative cell growth inhibition was detected in the case of polygallate-coated MNPs, while humic acid, citric acid, polyacrylic acid and polyacrylic-co-maleic acid coated particles [46] somewhat reduced cell growth, albeit well below the limit of direct antiproliferative effect (25% cell inhibition). We have used in previous antiproliferative assays four different cell lines [46] including both healthy and cancer cells for testing the biocompatibility of five different polyacid-coated MNPs.…”

“…Similar negative cell growth inhibition was detected in the case of polygallate-coated MNPs, while humic acid, citric acid, polyacrylic acid and polyacrylic-co-maleic acid coated particles [46] somewhat reduced cell growth, albeit well below the limit of direct antiproliferative effect (25% cell inhibition). We have used in previous antiproliferative assays four different cell lines [46] including both healthy and cancer cells for testing the biocompatibility of five different polyacid-coated MNPs. Our present and previous results taking together are in line with the observations of Thorat at al [47] who also found only slight variations in the viability of different cell lines after incubating them with polymer-encapsulated MNPs.…”

Multiscale simulations of the hydration shells surrounding spherical Fe3O4nanoparticles and effect on magnetic properties

“…This agrees well with previous experimental work, in which a high density of hydroxyl groups at the surface of Fe 3 O 4 NPs was found when exposed to water vapor. 28 By comparing the simulated extended X-ray absorption fine structure (EXAFS) of Fe 3 O 4 bulk, of the NP under vacuum and of the water-saturated NP (with one adsorbed monolayer), as shown in Fig. S1 in the ESI, † we can conclude that water adsorption improves the degree of crystallinity of the NP due to the saturation of low-coordinated Fe ions on the surface.…”

“…By XPS and isosteric heat of adsorption, Tombácz proposed that a high density of hydroxyl groups exists at the surface of Fe 3 O 4 NPs when exposed to water vapor. 28 By high-energy X-ray scattering, three distinct interatomic distance peaks (1.48, 1.95 and 2.39 Å) around faceted Fe 3 O 4 NPs in water were found, which are attributed to hydrogen bonds between surface O atoms and H atoms in water, the Fe-O distance between Fe atoms on the surface and O atoms in molecular and dissociated water molecules. 29 To our knowledge, the theoretical study of magnetite NPs in water has not yet been performed for the main reason that the accurate simulation of magnetite NPs of realistic size in bulk water with quantum chemical methods is computationally very demanding.…”