t(1;11)(p32;q23)

Spontaneous remission of congenital AML with skin involvement and t(1;11)(p32;q23)

“…Thirty-eight percent of reported leukemia patients with t(1;11)(p32;q23) were infants equally distributed between acute lymphoblastic leukemia (ALL) and AML. 5,6 This translocation was also seen in monozygotic twins with ALL and therapy-related ALL. 7,8 No cases of spontaneously resolving leukemia with t(1;11)(p32;q23) have been reported.Leukemia cutis is noted frequently at the onset of disease; rare cases preceding diagnosis were reported, likely at the aleukemic phase.…”

“…While AML with the t(1;11)(q21;q23) has 100% overall survival rate in childhood, the prognosis of t(1;11)(p32;q23) AML was dismal with a median survival of 15 months. Thirty‐eight percent of reported leukemia patients with t(1;11)(p32;q23) were infants equally distributed between acute lymphoblastic leukemia (ALL) and AML . This translocation was also seen in monozygotic twins with ALL and therapy‐related ALL .…”