t(11;19)(q21;p12∼p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma

The EML4‐ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild‐type EGFR and KRAS

“…20 The chromosomal translocation t (11;19) that results in the oncogenic CREB-regulated transcription coactivator 1-mastermind-like 2 fusion gene CRTC1-MAML2 has been identified in MECs of the salivary glands and lungs. [20][21][22] Overall, our findings and the reported data together suggest that EML4-ALK may be involved in NSCLC subtypes derived from large or proximal airway cells. Most of the patients who had EML4-ALK were primarily nonsmokers (10 never smokers; 2 passive smokers), and the association was statistically significant when all patients were included in the analysis.…”

Chromosomal imbalances, 11q21 rearrangement and MECT1-MAML2 fusion transcript in mucoepidermoid carcinomas of the salivary gland

“…This frequency is in agreement with studies on MECs by other authors (11,19). Several authors concluded that fusion positive tumors are biologically less aggressive with better clinicopathological behavior in comparison with fusion transcript negative tumors (11,20,32,33).…”

“…The fusion transcript activates the transcription of the Notch target genes such as HES1 and HES5 (18,19). This fusion gene is also shared in lung mucoepidermoid carcinoma (20,21). Clear cell hidradenoma of the skin as the third tumor type with an identical MECT1-MAML2 gene fusion was reported by Winnes et al (22) and Behboudi et al (23).…”

“…Fusion-positive patients had a significant lower risk of local recurrence, metastases and tumor-related death. According to the study by Serra et al (20) all analyzed pulmonary MECs with 11q21 rearrangement were low-grade tumors. In contrast to these Table I).…”

Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma

“…To our knowledge our data have the largest number of adult bronchopulmonary MEC subjects evaluated for the MAML2 gene rearrangement and MECT1-MAML2 expression in paraffin sections [17]. FISH analysis detected MAML2 gene rearrangement in 77% (13/ 17) of the bronchopulmonary MEC cases.…”