t(14;19)(q32;q13) incidence and significance in B‐cell lymphoproliferative disorders

BCL3 rearrangement, amplification and expression in diffuse large B-cell lymphoma

“…Both DLBCLs in the study of Kelly et al. (19) that were associated with t(14;19) had a past history of CLL. Similarly, in the four cases of B‐cell lymphomas (two small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL), one DLBCL and one Burkitt‐like lymphoma) reported by Au et al.…”

Thalassemia major in a 49‐year‐old Thai female: Gross and X‐ray examination of dry bone

“…Recent research that combined macroscopic and paleohistological approaches identified thalassemia in a further two prehistoric sites from Northern Vietnam (Vlok et al, 2021). One site (Man Bac) is contemporaneous with the cases reported by Tayles (1996), where up to Weatherall, 2008;Figure 13). Therefore, identification of thalassemia in Southeast Asian antiquity may illuminate the complex co-evolutionary histories of human populations with malaria in the region.…”

correspondence: BCL3 translocation in CLL with typical phenotype: assessment of frequency, association with cytogenetic subgroups, and prognostic significance

“…Few series of CLL harbouring BCL3 translocation have been so far reported. All these reports agreed that CLL harbouring BCL3 translocation is preferentially associated with atypical morphology and phenotype, and may be best described as: (i) small B‐cell leukaemias with atypical morphology (7/7 cases) and a phenotypic score ranging from 1 to 3 (7/7 cases) (Huh et al , 2007); (ii) CLL with atypical morphology (20/30 cases) and low phenotypic score (14/18 cases) (Chapiro et al , 2008); and (iii) CLL with atypical morphology/phenotype (12/27 cases), or lacking CD23 expression (5/8 cases) (Martín‐Subero et al , 2007); (iv) CLL lacking CD23 expression (3/4 cases) (Kelly et al , 2008). From a biological point of view, BCL3 translocations in atypical CLL have been associated with presence of +12, unmutated IGHV genes, and biased usage of the IGHV4‐39 / IGHD6‐13 / IGHJ5 rearrangement (Martín‐Subero et al , 2007; Chapiro et al , 2008).…”

“…From a biological point of view, BCL3 translocations in atypical CLL have been associated with presence of +12, unmutated IGHV genes, and biased usage of the IGHV4‐39 / IGHD6‐13 / IGHJ5 rearrangement (Martín‐Subero et al , 2007; Chapiro et al , 2008). From a clinical point of view, BCL3 translocations in atypical CLL might mark an aggressive course and an increased risk of transformation to aggressive lymphoma (Huh et al , 2007; Martín‐Subero et al , 2007; Chapiro et al , 2008; Kelly et al , 2008). Based on these observations, it has been suggested that B‐cell lymphoproliferative disorders carrying the t(14;19)(q32.3;q13.2) translocation might represent an entity distinct from CLL, provisionally termed as ‘t(14;19)‐positive small B‐CLL leukaemia’ (Huh et al , 2007).…”

“…BCL3 translocation, occurring as a consequence of t(14;19) (q32.3;q13.2), is a recurrent genetic lesion shared by several B‐cell malignancies, including chronic lymphocytic leukaemia (CLL), chronic B‐cell lymphoproliferative disorders, aggressive lymphomas and Hodgkin lymphoma (Michaux et al , 1996, 1997; McKeithan et al , 1997; Au et al , 2002; Martín‐Subero et al , 2006, 2007; Huh et al , 2007, Chapiro et al , 2008; Kelly et al , 2008).…”