T-786C Polymorphism in Promoter of eNOS Gene as Genetic Risk Factor in Patients With Erectile Dysfunction in Turkish Population

Sinici, İncilay; Güven, Eşref Oğuz; Serefoglu, E.C.; Hayran, Mutlu

doi:10.1016/j.urology.2009.06.063

Cited by 35 publications

(29 citation statements)

References 30 publications

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“…Besides, 2 low-quality studies were also excluded ( Figure 1 ). Finally, 12 studies were enrolled into our meta-analysis 22526373839404142434445. The subjects in these 12 studies were Asians (5 studies) and Caucasians (7 studies), and the studies contained a combined total of 1962 ED patients and 1752 healthy controls.…”

Section: Resultsmentioning

confidence: 99%

“…Our findings demonstrated the association between T-786C and the risk of ED. Low eNOS mRNA and serum nitrite levels were observed in individuals carrying the CC allele of T-786C polymorphism and homozygosity in this polymorphism correlated with reduced eNOS expression in human endothelial cells and decreased NO-induced vasomotor function 44. The G894T polymorphism results in an amino acid substitution in eNOS, altering its activity.…”

Section: Discussionmentioning

confidence: 97%

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Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction

et al. 2017

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The purpose of our meta-analysis is to examine the associations between three single nucleotide polymorphisms of endothelial nitric oxide synthase (eNOS) gene, G894T, intron 4 and T-786C, and the risk of erectile dysfunction. An electronic database search was performed to identify case-control studies reporting the association between single nucleotide polymorphisms of eNOS gene and erectile dysfunction. Stringent inclusion and exclusion criteria were employed to select high-quality studies for this meta-analysis. Comprehensive Meta-analysis 2.0 software (Biostat Inc., Englewood, New Jersey, USA) was used for statistical analysis of the data extracted from the selected studies. From the initial 203 articles retrieved from database search, this meta-analysis finally selected 12 high-quality case-control studies that conformed to our inclusion criteria. The 12 studies contained a total of 1962 patients with erectile dysfunction and 1752 healthy controls. The results of our meta-analysis showed that G894T correlated with an increased risk erectile dysfunction under both the allele and dominant models (allele: OR = 1.556, 95% CI = 1.064–2.275, P = 0.023; dominant: OR = 1.613, 95% CI = 1.050–2.476, P = 0.029). A similar association was found between T-786C and erectile dysfunction under the allele model (OR = 1.679, 95% CI = 1.341–2.102, P < 0.001), but not under the dominant model (all P > 0.05). Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction

et al. 2017

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“…It was hypothesized that rapid activation of neuronal NOS initiates the erectile process, whereas phosphorylation and activation of eNOS lead to sustained erection. 4 The en- dothelial and neuronal forms of the NOS enzyme are encoded by different genes with eNOS mapped to chromosome 7q35 and consisting of 26 exons spanning 21 kb of DNA. Several polymorphisms of eNOS have been investigated.…”

Section: Nitric Oxide Synthasementioning

confidence: 99%

“…5,16 T-789C is an independent predisposing factor for ED in Iranian and Turkish men. 4,16 However, data supporting its role in other populations are lacking.…”

Section: Nitric Oxide Synthasementioning

confidence: 99%

Genetics of Erectile Dysfunction

Lopushnyan

Chitaley

2012

Journal of Urology

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Studies investigating the genetics of erectile dysfunction are mostly derived from animal models and candidate gene approaches. Candidate gene studies omit the greater portion of the genome, a problem that can be solved using a genome wide association study approach. The lack of persistently replicated results of candidate gene studies may be related to different patient ethnic backgrounds, variations in erectile dysfunction etiology and small sample sizes. Using strict inclusion/exclusion criteria for erectile dysfunction etiology and ethnicity in human studies may lead to improved understanding of the genetics of erectile dysfunction in specific populations.

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“…Initiale Studien wiesen auf eine erniedrigte eNOS-Konzentration und Aktivität im Serum hin, was sich aber durch Serummessungen nicht bestä-tigen ließ[57]. Mehrere Assoziationsstudien in verschiedenen Ethnien konnten bisher keinen Zusammenhang zwischen dem VNTR-Genotyp und dem ED-Risiko belegen[17, 18, 38,52,56]. Das T-Allel im eNOS G894T-Polymorphismus in Exon 7 des eNOS-Gens führt zu einem Austausch von Glutamat durch Asparagin an Position 298 des Proteins[25].…”

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