T and NK Cell-Based Immunotherapy in Chronic Viral Hepatitis and Hepatocellular Carcinoma

Fisicaro, Paola; Boni, Carolina

doi:10.3390/cells11020180

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…M2 macrophages play an important role in the formation of an immunosuppressive microenvironment [ 46 ]. Notably, NK cells showed dysfunction in HCC [ 47 ], but we found that G6PD was associated with KIR2DL4, a marker of NK cells. Recent studies have found that blocking the binding of KIR2DL4 to the ligand on NK cells can restore the sensitivity of breast cancer to trastuzumab [ 48 ].…”

Section: Discussionmentioning

confidence: 86%

Construction of a competing endogenous RNA network to analyse glucose-6-phosphate dehydrogenase dysregulation in hepatocellular carcinoma

et al. 2022

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Hepatocellular carcinoma (HCC) is a common malignant tumour with high rates of morbidity and mortality worldwide. Therefore, it is of great significance to find new molecular markers for HCC diagnosis and treatment. G6PD is known to be dysregulated in a variety of tumours. In addition, the ceRNA network plays a crucial role in the occurrence and development of HCC. However, the mechanism by which the ceRNA network regulates G6PD in HCC remains unclear. We used TCGA-LIHC data to analyse the possibility of using G6PD as an independent prognostic marker. UCR, MCR, and ROC analysis were used to analyse the influence of G6PD overexpression on the prognosis of HCC patients. We also analysed the biological function of G6PD, its effect on the immune microenvironment, and drug sensitivity. Finally, we constructed a ceRNA network of lncRNAs/miR-22-5p/G6PD to explore the regulatory mechanism of G6PD. G6PD was highly expressed in HCC, was related to pathological stage and poor prognosis, and could be used as an independent prognostic indicator of HCC. The expression of G6PD was closely related to the immune microenvironment of HCC. In addition, the expression of G6PD in HCC could be regulated by the ceRNA network. Therefore, G6PD can be used as an immunotherapy target to improve the survival and prognosis of HCC patients, and the ceRNA regulatory network of G6PD has potential diagnostic and therapeutic value for HCC.

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Section: Discussionmentioning

confidence: 86%

Construction of a competing endogenous RNA network to analyse glucose-6-phosphate dehydrogenase dysregulation in hepatocellular carcinoma

et al. 2022

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“…Due to the importance to human health, the current success of cell therapy is mainly based on the use of immune cells, especially T cells, as the chassis therapeutic cells. More recently, other immune cells, such as natural killer cells, macrophages, have shown considerable potential not only in cancer treatment but also in treating infectious diseases (Fisicaro and Boni, 2022;Klichinsky et al, 2020). While many cells being engineered as drugs are still at proof-ofconcept , we envision that once we can design more accurate and functional gene and cellular circuits, engineering at the primary cell level will be easier.…”

Section: Engineered Living Cell Therapeuticsmentioning

confidence: 99%

Enabling technology and core theory of synthetic biology

Zhang

Liu

Dai

et al. 2023

Sci. China Life Sci.

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Synthetic biology provides a new paradigm for life science research (“build to learn”) and opens the future journey of biotechnology (“build to use”). Here, we discuss advances of various principles and technologies in the mainstream of the enabling technology of synthetic biology, including synthesis and assembly of a genome, DNA storage, gene editing, molecular evolution and de novo design of function proteins, cell and gene circuit engineering, cell-free synthetic biology, artificial intelligence (AI)-aided synthetic biology, as well as biofoundries. We also introduce the concept of quantitative synthetic biology, which is guiding synthetic biology towards increased accuracy and predictability or the real rational design. We conclude that synthetic biology will establish its disciplinary system with the iterative development of enabling technologies and the maturity of the core theory.

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“…such as: lung cancer [7], hematological tumors [8,9],glioblastoma [10], pancreatic cancer [11],breast cancer [12]and so on. Recent studies have also claimed that NK cells are extremely correlated with HCC, with a decrease in NK cells numbers leading to rapid growth of liver cancer cells and that the poor prognosis of HCC patients is closely linked to failure of cells failure [13][14][15].Thus, it appears that NK cells play the pivotal role in HCC [16]. However, due to some potential biases in studies, such as confounding factors or reverse causation, whether there is a causal correlation between NK cell-associated immune traits and development of HCC remains to be further con rmed and systematically studied.…”

Section: Introductionmentioning

confidence: 99%

The causality between CD8 + NKT cells and CD16 - CD56 on NK cells with hepatocellular carcinoma: a Mendelian randomization study

Pan

Chai

et al. 2023

Preprint

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Background Hepatocellular carcinoma (HCC), which is featured with high morbidity and mortality worldwide, is a primary malignant tumor of the liver. Recently, there is a wealth of supporting evidence revealing that NK cell-related immune traits are strongly associated with the development of HCC, but the causality between them has not been proven.Methods Two-sample Mendelian randomization (MR) study was performed to probe the causal correlation between NK cell-related immune traits and HCC. Genetic variations in NK cell-related immune traits were extracted from recent genome-wide association studies (GWAS) of individuals with European blood lineage. HCC data were derived from the UK Biobank Consortium's GWAS summary count data, including a total of 372184 female and male subjects, with 168 cases and 372016 controls, all of whom are of European ancestry. Sensitivity analysis was mainly used for heterogeneity and pleiotropy testing.Results Our research indicated the causality between NK cell-related immune traits and HCC. Importantly, CD8+NKT cells had protective causal effects on HCC (OR = 0.9996;95%CI,0.9993–0.9999; P = 0.0489). CD16−CD56 caused similar effects on NK cells (OR = 0.9997;95%CI,0.9996–0.9999; P = 0.0117) as CD8+NKT cells. Intercepts from Egger showed no pleiotropy and confounding factors. Furthermore, insufficient evidence was found to support the existence of heterogeneity by Cochran's Q test.Conclusion MR analysis elucidated that low CD8+NKT cells and CD16−CD56 expression on NK cells were linked with a higher risk of HCC.

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T and NK Cell-Based Immunotherapy in Chronic Viral Hepatitis and Hepatocellular Carcinoma

Abstract: In chronic viral hepatitis and in hepatocarcinoma (HCC), antigen-specific T cells are deeply exhausted, and evidence of dysfunction has also been observed for NK cells, which can play a pathogenetic role, exerting a regulatory activity on adaptive immune responses [...]

Cited by 6 publications

References 10 publications

Construction of a competing endogenous RNA network to analyse glucose-6-phosphate dehydrogenase dysregulation in hepatocellular carcinoma

Construction of a competing endogenous RNA network to analyse glucose-6-phosphate dehydrogenase dysregulation in hepatocellular carcinoma

Enabling technology and core theory of synthetic biology

The causality between CD8 + NKT cells and CD16 - CD56 on NK cells with hepatocellular carcinoma: a Mendelian randomization study

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