T‐box genes in the ascidian <i>Ciona intestinalis</i>: Characterization of cDNAs and spatial expression

Takatori, Naohito; Hotta, Kohji; Mochizuki, Yasuaki; Satoh, Gouki; Mitani, Yasuo; Satoh, Nori; Satou, Yutaka; Takahashi, Hiroshi

doi:10.1002/dvdy.20082

Cited by 63 publications

(68 citation statements)

References 47 publications

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“…Extensive studies have been performed in the urochordate Ciona (Davidson and Levine, 2003;Takatori et al, 2004;Davidson, 2007), where nine T-box genes have been annotated (representatives of 7 of the 8 T-box subfamilies, Davidson, 2007). Although there is not Ciona ortholog of Tbx4/5 and Tbx20 is not expressed in the embryo, Tbx6 (which is a duplicated locus in Ciona) seems to play a main role in cardiac development (Davidson, 2007).…”

Section: Myocardial Origin and Diversitymentioning

confidence: 99%

Building the vertebrate heart - an evolutionary approach to cardiac development

2009

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The vertebrate heart is unique among the blood pumps described in metazoans. In contrast to the myoepithelial tubes found in most animal phyla, the vertebrate heart is made up of multilayered myocardial cells surrounded by connective tissue derived from epicardium and endocardium, and endowed with complex valvular, coronary vessel and conduction systems. Despite these profound differences, a common genetic program seems to underlie the specification and differentiation of all the cardiac tissues. In this article, we will review the similarities in the transcriptional networks and signalling mechanisms regulating cardiac development in different animals, as well as the origin of the main differences existing between vertebrate and invertebrate hearts. We will pay special attention to the hypotheses concerning the evolutionary origin of the endothelium and the epicardium from ancestral blood cells and pronephric progenitors, respectively. We can summarize the transition between the invertebrate and the vertebrate heart as the result of the thickening of the primarily myoepithelial cardiac tube which was concomitant with: 1) an inner lining by an endothelium with the ability to transform into mesenchyme; 2) an outer lining derived from an ancestral pronephric glomerular primordium with vasculogenic potential; 3) a neural crest cell population which reaches the heart from the pharyngeal region; 4) the incorporation of new myocardium at both ends from a second heart field and 5) the formation of specialized chambers. The complex interactions between all these elements originated an exceptionally powerful blood pump which allowed vertebrates to reach their characteristically large size and activity.

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Section: Myocardial Origin and Diversitymentioning

confidence: 99%

Building the vertebrate heart - an evolutionary approach to cardiac development

2009

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“…For example, there are three Tbx6 genes in the C. intestinalis genome, resulting from lineage-specific duplications (Takatori et al, 2004). Cyclooxygenase (COX) also appears to have undergone independent duplication events in ascidians and vertebrates (Jarving et al, 2004).…”

Section: Ascidian Genomicsmentioning

confidence: 99%

“…These results suggest that these structural muscle genes are downstream of As-T2 (Mitani et al, 2001). In C. intestinalis, all three Tbx6 homologs are expressed in muscle precursors, and CiTbx6b has been suggested to be downstream of Ci-macho1 (Takatori et al, 2004;Yagi et al, 2004b).…”

Section: Musclementioning

confidence: 99%

Ciona intestinalis: Chordate development made simple

2005

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Thanks to their transparent and rapidly developing mosaic embryos, ascidians (or sea squirts) have been a model system for embryological studies for over a century. Recently, ascidians have entered the postgenomic era, with the sequencing of the Ciona intestinalis genome and the accumulation of molecular resources that rival those available for fruit flies and mice. One strength of ascidians as a model system is their close similarity to vertebrates. Literature reporting molecular homologies between vertebrate and ascidian tissues has flourished over the past 15 years, since the first ascidian genes were cloned. However, it should not be forgotten that ascidians diverged from the lineage leading to vertebrates over 500 million years ago. Here, we review the main similarities and differences so far identified, at the molecular level, between ascidian and vertebrate tissues and discuss the evolution of the compact ascidian genome.

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“…In Ciona, Ci-Tbx1/10 transcripts can be detected in dorsal endodermal cells until hatching (Takatori et al 2004). Amphioxus Tbx1/10 (AmphiTbx1/10) is expressed in a bilateral segmented pattern in the ventral half of somites and branchial arches of neurulae (Mahadevan et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Identification and developmental expression of two Tbx1/10-related genes in the agnathan Lethenteron japonicum

et al. 2007

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We have identified two Tbx1/10-related genes, LjTbx1/10A and LjTbx1/10B, from the Japanese river lamprey Lethenteron japonicum. We used in situ hybridization to characterize their expression pattern during embryonic development. LjTbx1/10A and LjTbx1/10B shared common expression in the pharyngeal arches and otic vesicle, although their levels and timing of expression differed markedly. LjTbx1/10A was highly expressed in the mesodermal core of pharyngeal arches and the adjacent endoderm throughout pharyngeal arch development, whereas LjTbx1/10B expression was only transiently upregulated in forming pharyngeal pouches. LjTbx1/10A transcripts first appeared at stage 25 in otic vesicles, whereas LjTbx1/10B transcripts could already be detected in the developing otic placode at stage 20. These results suggest that lamprey LjTbx1/10A and LjTbx1/10B may play distinct roles in the patterning and development of the pharyngeal apparatus. It appears that lamprey Tbx1/10 genes have undergone subfunctionalization independent from gnathostomes, with regard to both regulation and function.

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T‐box genes in the ascidian Ciona intestinalis: Characterization of cDNAs and spatial expression

Cited by 63 publications

References 47 publications

Building the vertebrate heart - an evolutionary approach to cardiac development

Building the vertebrate heart - an evolutionary approach to cardiac development

Ciona intestinalis: Chordate development made simple

Identification and developmental expression of two Tbx1/10-related genes in the agnathan Lethenteron japonicum

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