T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward

Pai, Madhukar; Dheda, Keertan; Cunningham, Jane; Scano, Fabio; O’Brien, Richard

doi:10.1016/s1473-3099(07)70086-5

Cited by 145 publications

(120 citation statements)

References 75 publications

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“…This would be particularly useful for children, immunosuppressed individuals and patients with negative cultures, for whom the diagnosis of active disease is more difficult to be established using the conventional assays. 13 Although some aspects still remain controversial, in general, the IGRAs are accepted as being more sensitive and specific than the TST for the diagnosis of latent infection and active disease. However, there is need for longitudinal studies that make it possible to confirm these data in a In terms of public health, the IGRAs could be, at least currently, a complement to the TST, assessing the costbenefit ratio.…”

Section: Resultsmentioning

confidence: 99%

“…Oxlade et al 115 concluded that the best cost-benefit ratio of the QFT would when there is probability of finding false-negative TST results, as it is the case for immunosuppressed individuals and young children, these assays would be indicated for use in the initial phase of investigation. 13,14,68,87 Negative TST and IGRAs results in immunosuppressed population do not rule out latent TB or active disease, at least currently. In practical terms, individuals with these negative assays, but with risk factors for progression from latent TB to active disease, could need chemoprophylaxis or disease treatment.…”

Section: Resultsmentioning

confidence: 99%

“…Seven major priority lines of research on the assays were defined during this meeting (Table 2). 13 In spite of the large number of recent studies published, many questions remain unanswered. The IGRAs ability to identify patients with latent infection at a higher risk of progression to active disease and, therefore, to…”

Section: Resultsmentioning

confidence: 99%

“…The presence of positive cultures for Mycobacterium tuberculosis would be the gold standard for the diagnosis of the active disease. 12,13 With regard to the latent infection, it is not possible to predict which patients will progress to active disease.…”

Section: Introductionmentioning

confidence: 99%

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O desafio da tuberculose na faixa etária pediátrica frente a novas técnicas diagnósticas

Sztajnbok

Boecha

Sztajnbok

et al. 2009

J. Pediatr. (Rio J.)

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Objectives: To present an updated review concerning new assays for diagnosing tuberculosis based on in vitro interferon-gamma production by host T cells, and to compare them with tuberculin skin test.Sources: A literature review was carried out based on MEDLINE and LILACS databases (2000-2008) searching for the following keywords: tuberculosis, interferon-gamma, quantiFERON, ELISPOT and T-SPOT.TB. Summary of the findings:These new assays proved to have, in general, equal or superior sensitivity and specificity than the tuberculin skin test not only in adults but also in children and immunosuppressed patients for the diagnosis of both latent tuberculosis infection or active disease, with some advantages such as less cross-reactivity as a result of previous BCG vaccination, less influence of anergy and better accuracy in small children. In the United States, these assays have been used instead of the tuberculin skin test and, although still very expensive, the World Health Organization will be making its economic viability a priority. Conclusions:Always having in mind the importance of clinical and epidemiological histories, these new assays based on interferon-gamma release present promising results and should be considered in tuberculosis investigation procedures for all patients, however with a special concern in the risk groups (i.e., children and immunosuppressed patients).J Pediatr (Rio J). 2009;85(3):183-193: Tuberculosis, interferon-gamma, quantiFERON, ELISPOT, children, immunosuppression.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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O desafio da tuberculose na faixa etária pediátrica frente a novas técnicas diagnósticas

Sztajnbok

Boecha

Sztajnbok

et al. 2009

J. Pediatr. (Rio J.)

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“…Les gènes qui codent les antigènes sont présents dans le M tuberculosis, mais pas dans les souches de BCG ni dans plusieurs souches environnementales de MNT (12)(13)(14). Par conséquent, ces tests sont beaucoup plus spécifiques (provoquant moins de faux-positifs) que l'IDR.…”

Section: Les Progrès Dans Le Diagnostic De Tb : Les Tests De Détectiounclassified

La tuberculose chez les enfants : de nouvelles analyses sanguines diagnostiques

Kakkar¹,

Allen²,

Ling³

et al. 2010

Paediatrics &Amp; Child Health

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Splenic Tuberculosis in a Patient with Crohnʼs Disease on Infliximab: Case Report

Cappello

Randazzo

Rizzuto

et al. 2010

Inflammatory Bowel Diseases

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T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward

Cited by 145 publications

References 75 publications

O desafio da tuberculose na faixa etária pediátrica frente a novas técnicas diagnósticas

O desafio da tuberculose na faixa etária pediátrica frente a novas técnicas diagnósticas

La tuberculose chez les enfants : de nouvelles analyses sanguines diagnostiques

Splenic Tuberculosis in a Patient with Crohnʼs Disease on Infliximab: Case Report

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