T Cell Calcium Signaling Regulation by the Co-Receptor CD5

Freitas, Claudia M. Tellez; Johnson, Deborah; Weber, K. Scott

doi:10.3390/ijms19051295

Cited by 25 publications

(16 citation statements)

References 208 publications

(282 reference statements)

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“…High levels of ROS in the TME inhibit T-cell proliferation and antitumor function leading to T-cell hyporesponsiveness. Tumor-infiltrating lymphocytes (TILs) suffer from reduced glycolytic capacity and cytokine production due to reduced Ca 2+ signaling attributed to such a glucose deprived TME [82,83]. Low levels of ROS are required for T-cell activation, proliferation and function as T-cell activation through stimulation of the T cell receptors (TCR) and costimulatory receptors induce signaling pathways and transcription factors.…”

Section: Effects Of Tumor Microenvironment (Tme) Metabolism On Immunementioning

confidence: 99%

Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics

Ghoneum

Abdulfattah

Warren

et al. 2020

IJMS

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Reactive Oxygen Species or “ROS” encompass several molecules derived from oxygen that can oxidize other molecules and subsequently transition rapidly between species. The key roles of ROS in biological processes are cell signaling, biosynthetic processes, and host defense. In cancer cells, increased ROS production and oxidative stress are instigated by carcinogens, oncogenic mutations, and importantly, metabolic reprograming of the rapidly proliferating cancer cells. Increased ROS production activates myriad downstream survival pathways that further cancer progression and metastasis. In this review, we highlight the relation between ROS, the metabolic programing of cancer, and stromal and immune cells with emphasis on and the transcription machinery involved in redox homeostasis, metabolic programing and malignant phenotype. We also shed light on the therapeutic targeting of metabolic pathways generating ROS as we investigate: Orlistat, Biguandes, AICAR, 2 Deoxyglucose, CPI-613, and Etomoxir.

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Section: Effects Of Tumor Microenvironment (Tme) Metabolism On Immunementioning

confidence: 99%

Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics

Ghoneum

Abdulfattah

Warren

et al. 2020

IJMS

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“…CD5 antigen-positive T lymphocytes play a role in signal transduction. These cells work with some immune-related genes and immune factors to maintain immune homeostasis and normal immune function of the thymus (Freitas et al, 2018). Cyclin-dependent kinase, CDK6, is a driving factor for cell proliferation and can bind D cell cycle protein 3 to promote tumor cell apoptosis .…”

Section: Dmgs Involved In Immunity and Reproductionmentioning

confidence: 99%

Whole-Genome Methylation Analysis Reveals Epigenetic Variation in Cloned and Donor Pigs

Wang

Feng

et al. 2020

Front. Genet.

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Somatic cloning has had a significant impact on the life sciences and is important in a variety of processes, including medical research and animal production. However, the application of somatic cloning has been limited due to its low success rate. Therefore, potential epigenetic variations between cloned and donor animals are still unclear. DNA methylation, one of the factors which is responsible for phenotypic differences in animals, is a commonly researched topic in epigenetic studies of mammals. To investigate the epigenetic variations between cloned and donor animals, we selected blood and ear fibroblasts of a donor pig and a cloned pig to perform whole-genome bisulfite sequencing (WGBS). A total of 215 and 707 differential methylation genes (DMGs) were identified in blood and ear fibroblasts, respectively. Functional annotation revealed that DMGs are enriched in many pathways, including T/B or natural killer (NK) cell differentiation, oocyte maturation, embryonic development, and reproductive hormone secretion. Moreover, 22 DMGs in the blood and 75 in the ear were associated with immune responses (e.g., CD244, CDK6, CD5, CD2, CD83, and CDC7). We also found that 18 DMGs in blood and 53 in ear fibroblasts were involved in reproduction. Understanding the expression patterns of DMGs, especially in relation to immune responses and reproduction, will reveal insights that will aid the advancement of future somatic cloning techniques in swine.

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“…PECs harbor CD5 and/or CD6 expressing immune cells involved in helminth infection protection. They include all T cells (comprising Tγδ and iNKT) and B1a cells as well as a macrophage subset [81]. Interestingly, CD5 + B1a cells are an important source of polyreactive natural IgM antibodies [82] and of IL-10 [83].…”

Section: Discussionmentioning

confidence: 99%

The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis

et al. 2018

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BackgroundScavenger Receptors (SRs) from the host’s innate immune system are known to bind multiple ligands to promote the removal of non-self or altered-self targets. CD5 and CD6 are two highly homologous class I SRs mainly expressed on all T cells and the B1a cell subset, and involved in the fine tuning of activation and differentiation signals delivered by the antigen-specific receptors (TCR and BCR, respectively), to which they physically associate. Additionally, CD5 and CD6 have been shown to interact with and sense the presence of conserved pathogen-associated structures from bacteria, fungi and/or viruses.Methodology/Principal findingsWe report herein the interaction of CD5 and CD6 lymphocyte surface receptors with Echinococcus granulosus sensu lato (s.l.). Binding studies show that both soluble and membrane-bound forms of CD5 and CD6 bind to intact viable protoscoleces from E. granulosus s.l. through recognition of metaperiodate-resistant tegumental components. Proteomic analyses allowed identification of thioredoxin peroxidase for CD5, and peptidyl-prolyl cis-trans isomerase (cyclophilin) and endophilin B1 (antigen P-29) for CD6, as their potential interactors. Further in vitro assays demonstrate that membrane-bound or soluble CD5 and CD6 forms differentially modulate the pro- and anti-inflammatory cytokine release induced following peritoneal cells exposure to E. granulosus s.l. tegumental components. Importantly, prophylactic infusion of soluble CD5 or CD6 significantly ameliorated the infection outcome in the mouse model of secondary cystic echinococcosis.Conclusions/SignificanceTaken together, the results expand the pathogen binding properties of CD5 and CD6 and provide novel evidence for their therapeutic potential in human cystic echinococcosis.

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T Cell Calcium Signaling Regulation by the Co-Receptor CD5

Cited by 25 publications

References 208 publications

Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics

Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics

Whole-Genome Methylation Analysis Reveals Epigenetic Variation in Cloned and Donor Pigs

The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis

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