T cell contributions to the different phases of granuloma formation

Co, Dominic O.; Hogan, Laura H.; Kim, Shin Il; Sándor, Mátyás

doi:10.1016/j.imlet.2003.11.023

Cited by 103 publications

(76 citation statements)

References 102 publications

(104 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Granulomatous inflammation is a delayed type hypersensitivity reaction, representing a complex process of macrophage recruitment and organization, controlled by numerous cytokines, T cells, and other mediators [11]. As in other sites, granulomatous inflammation in lymph nodes has a long list of causes, and these can often be distinguished based on the morphologic appearance of the granulomas or pattern of histiocytic infiltrates.…”

Section: Discussionmentioning

confidence: 99%

Perifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Perifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis

et al. 2011

View full text Add to dashboard Cite

show abstract

“…While T cells are essential for granuloma function in all instances (36), the presence of B cells varies according to the granuloma-inducing pathogen. Histoplasma-induced liver granulomas also contain a B220 ϩ /MHC class II ϩ B cell component representing ϳ10% of lymphocyte-gated cells during the acute infection and increasing to ϳ20% of lymphocyte-gated cells at day 50 after infection ( Fig.…”

Section: Tcr Usage In Granuloma-infiltrating T Cellsmentioning

confidence: 99%

Characterization of theHistoplasma capsulatum-Induced Granuloma

Héninger

Hogan²,

Karman

et al. 2006

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

Rising rates of Histoplasma capsulatum infection are an emerging problem among the rapidly growing population of immune-compromised individuals. Although there is a growing understanding of systemic immunity against Histoplasma, little is known about the local granulomatous response, which is an important component in the control of infection. The focus of this article is the characterization of Histoplasma-induced granulomas. Five days after i.p. infection, infected macrophage appear in the liver and lung; however, no granulomas are apparent. Two days later, well-formed sarcoid granulomas are abundant in the lung and liver of infected mice, which contain all visible Histoplasma. Granulomas are dominated by macrophage and lymphocytes. Most of the Histoplasma and most of the apoptotic cells are found in the center of the lesions. We isolated liver granulomas at multiple time points after infection and analyzed the cellular composition, TCR gene usage, and cytokine production of granuloma-infiltrating cells. The lesions contain both CD4+ and CD8+ T cell subsets, and T cells are the primary source of IFN-γ and IL-17. The main source of local TNF-α is macrophage. Chemokines are produced by both infiltrating macrophage and lymphocytes. Dendritic cells are present in granulomas; however, T cell expansion seems to occur systemically because TCR usage is very heterogeneous even at the level of individual lesions. This study is the first direct examination of host cellular responses in the Histoplasma-induced granuloma representing the specific interface between host and pathogen. Our studies will allow further analysis of key elements of host Histoplasma interactions at the site of chronic infection.

show abstract

“…Sixty mg PPE Pm /kg BW was the dose of choice, because 33% mortality was observed with a dose of 180 mg/kg BW (data not shown). On the other hand, taking into account the predominant role of T-cells in the development of granulomatous infl ammation (Co et al, 2004) and the slight thymic atrophy that accompanies the inhibition of granuloma formation by PPE Pm and bromelain, also observed for Bromelia hieronymi extracts (Errasti et al, 2013), one might assume that part of the anti-infl ammatory action involves the regulation of T-cell activity.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Anti-Inflammatory Activity of Pseudananas macrodontes (Morr.) Harms (Bromeliaceae) Fruit Extract in Rats

Errasti

Caffini

Pelzer

et al. 2013

Zeitschrift Für Naturforschung C

View full text Add to dashboard Cite

Several species of the family Bromeliaceae are characterized by the production of proteases in unusual amounts, especially in fruits. Bromelain, an extract rich in cysteine endopeptidases obtained from Ananas comosus L., and a few other proteases have been used as anti-infl ammatory agents for some years, but bromelain is still mainly being used as alternative and/or complementary therapy to the treatment with glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. In this study, the anti-infl ammatory action of a partially purifi ed extract from Pseudananas macrodontes (Morr.) Harms fruits (PPE Pm ) is presented, whose main components are cysteine endopeptidases. The effect of PPE Pm was assessed in carrageenan-induced and serotonin-induced rat paw edema, as well as in the cotton pellet granuloma model. Doses with equal proteolytic activity of PPE Pm and bromelain produced signifi cantly similar anti-infl ammatory responses in the acute infl ammatory models assayed, supporting the hypothesis that proteolytic activity could be responsible for the anti-infl ammatory action. On the contrary, comparable anti-infl ammatory effects of PPE Pm and bromelain in the chronic infl ammatory assay required a much lower proteolytic activity content of PPE Pm , which could be due to a differential affi nity for the protein target involved in this process.

show abstract

T cell contributions to the different phases of granuloma formation

Cited by 103 publications

References 102 publications

Perifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis

Perifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis

Characterization of theHistoplasma capsulatum-Induced Granuloma

Evaluation of Anti-Inflammatory Activity of Pseudananas macrodontes (Morr.) Harms (Bromeliaceae) Fruit Extract in Rats

Contact Info

Product

Resources

About