T cell control of the gut IgA response against commensal bacteria

Bos, Nicolaas A.; Hq, Jiang; Cebra, J J

doi:10.1136/gut.48.6.762

Cited by 57 publications

(45 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current evidence suggests that the majority of IgA molecules in the gut are induced by commensal bacteria and that there is a role for this transient population to induce a specific IgA response. 23,[52][53][54][55][56][57] A recent study performed by Hapfelmeier et al 54 confirms the role of commensal bacteria, but also describes the specific IgA response to be less robust and have a slower onset, consistent with our findings. Another relevant finding by Macpherson et al 23 showed induction of commensal-specific IgA antibodies to be mostly T cell independent but dependent largely on the B1 peritoneal B cells, a potential angle that should be evaluated in rice bran-fed mice.…”

Section: Discussionsupporting

confidence: 89%

Consumption of Rice Bran Increases Mucosal Immunoglobulin A Concentrations and Numbers of IntestinalLactobacillusspp.

Henderson

Kumar

Barnett

et al. 2012

Journal of Medicinal Food

View full text Add to dashboard Cite

Gut-associated lymphoid tissue maintains mucosal homeostasis by combating pathogens and inducing a state of hyporesponsiveness to food antigens and commensal bacteria. Dietary modulation of the intestinal immune environment represents a novel approach for enhancing protective responses against pathogens and inflammatory diseases. Dietary rice bran consists of bioactive components with disease-fighting properties. Therefore, we conducted a study to determine the effects of whole dietary rice bran intake on mucosal immune responses and beneficial gut microbes. Mice were fed a 10% rice bran diet for 28 days. Serum and fecal samples were collected throughout the study to assess total immunoglobulin A (IgA) concentrations. Tissue samples were collected for cellular immune phenotype analysis, and concentrations of native gut Lactobacillus spp. were enumerated in the fecal samples. We found that dietary rice bran induced an increase in total IgA locally and systemically. In addition, B lymphocytes in the Peyer's patches of mice fed rice bran displayed increased surface IgA expression compared with lymphocytes from control mice. Antigen-presenting cells were also influenced by rice bran, with a significant increase in myeloid dendritic cells residing in the lamina propria and mesenteric lymph nodes. Increased colonization of native Lactobacillus was observed in rice bran-fed mice compared with control mice. These findings suggest that rice bran-induced microbial changes may contribute to enhanced mucosal IgA responses, and we conclude that increased rice bran consumption represents a promising dietary intervention to modulate mucosal immunity for protection against enteric infections and induction of beneficial gut bacteria.

show abstract

Section: Discussionsupporting

confidence: 89%

Consumption of Rice Bran Increases Mucosal Immunoglobulin A Concentrations and Numbers of IntestinalLactobacillusspp.

Henderson

Kumar

Barnett

et al. 2012

Journal of Medicinal Food

View full text Add to dashboard Cite

show abstract

“…Thus, it is not surprising that most cells emerging from the IPP in sheep are B cells and not T cells (16). It appears then that JPP and "conventional" PP are especially dependent on CD 4 helper T cells, consistent with the concept that 1) the IgA response is T cell-dependent (28,29), 2) IgA responses are dependent on T cell cytokines (30), and 3) rescue from apoptosis depends on CD40/CD40L interactions (31). The T-independent response of mouse peritoneal B1 cells has not been confirmed in other species (32).…”

mentioning

confidence: 71%

Antibody Repertoire Development in Fetal and Neonatal Piglets. XX. B Cell Lymphogenesis Is Absent in the Ileal Peyer’s Patches, Their Repertoire Development Is Antigen Dependent, and They Are Not Required for B Cell Maintenance

Butler

Santiago-Mateo

Sun

et al. 2011

The Journal of Immunology

View full text Add to dashboard Cite

The continuous ileal Peyer’s patches (IPP) of sheep are regarded as a type of mammalian bursal equivalent where B cells diversify their repertoire in an Ag-independent fashion. Anatomically and developmentally similar IPP occur in swine. Resection of ∼90% of the IPP in piglets at birth did not alter Ig levels in serum and secretions or retard diversification of the Ab repertoire when animals were maintained in isolators and colonized with a defined gut flora. Resection or sham surgery elevated IgG and IgA in serum and in lavage fluid from the gut, lung, and in saliva. No changes in the frequency of IgG-, IgA-, and IgM-containing cells in the spleen and peripheral lymph node were observed. Using an index that quantifies diversification of the VDJ repertoire, no differences were seen in three secondary lymphoid tissues between piglets lacking IPP and colonized controls, whereas both groups displayed >10-fold greater diversification than did late-term fetal piglets or piglets maintained germ-free. Somatic hypermutation was very low in fetal IPP and the IPP of germ-free piglets but increased 3- to 5-fold after colonization. D–J signal joint circles were not recovered in IPP, and V–DJ signal joint circles were 5-fold lower than in bone marrow and similar to those in thymus and spleen. We conclude that the porcine IPP are not a site of B cell lymphogenesis, do not undergo Ag-independent repertoire diversification, and are not primary lymphoid tissue since they are not required for maintenance of Ig levels in serum and secretions.

show abstract

“…The intestinal microbiota have been demonstrated to be involved in the proper development of the intestinal immune system and in particular in the production of a diverse repertoire of SIgA (4) composed of at least 90% of natural SIgA with largely unknown specificity (8,15,16). The biological function of such SIgA remains speculative; however, various studies have underscored the natural coating of commensal bacteria by SIgA, a process that may be involved in the homeostatic gut sensing of the microbiota (12,41,44).…”

Section: Discussionmentioning

confidence: 99%

Recognition of Gram-positive Intestinal Bacteria by Hybridoma- and Colostrum-derived Secretory Immunoglobulin A Is Mediated by Carbohydrates

Mathias

Corthésy

2011

Journal of Biological Chemistry

100

View full text Add to dashboard Cite

T cell control of the gut IgA response against commensal bacteria

Cited by 57 publications

References 30 publications

Consumption of Rice Bran Increases Mucosal Immunoglobulin A Concentrations and Numbers of IntestinalLactobacillusspp.

Consumption of Rice Bran Increases Mucosal Immunoglobulin A Concentrations and Numbers of IntestinalLactobacillusspp.

Antibody Repertoire Development in Fetal and Neonatal Piglets. XX. B Cell Lymphogenesis Is Absent in the Ileal Peyer’s Patches, Their Repertoire Development Is Antigen Dependent, and They Are Not Required for B Cell Maintenance

Recognition of Gram-positive Intestinal Bacteria by Hybridoma- and Colostrum-derived Secretory Immunoglobulin A Is Mediated by Carbohydrates

Contact Info

Product

Resources

About