T-Cell Costimulation and Coinhibition in Graft-Versus-Host Disease and Graft-Versus-Leukemia Effect

Wu, Yongxia; Anasetti, Claudio; Yu, Xue-Zhong

doi:10.1016/b978-0-12-812630-1.00011-6

Cited by 3 publications

(4 citation statements)

References 291 publications

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“…T cell hyperactivation in COVID-19 is in accordance with findings from other groups (24,27). High proportions of CD226 + and CD244 + CD8 + T cells correspond to a described virus-specificity with increased cytotoxic effector function (28)(29)(30)(31). By exhibiting high proliferative and cytotoxic effector functions (25), these cells contribute to viral control (32).…”

Section: T Cell and Monocyte Phenotypes And Plasma Cytokines In Seversupporting

confidence: 84%

COVID-19 Impairs Immune Response to Candida albicans

Moser¹,

Biere²,

Han³

et al. 2021

Front. Immunol.

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Infection with SARS-CoV-2 can lead to Coronavirus disease-2019 (COVID-19) and result in severe acute respiratory distress syndrome (ARDS). Recent reports indicate an increased rate of fungal coinfections during COVID-19. With incomplete understanding of the pathogenesis and without any causative therapy available, secondary infections may be detrimental to the prognosis. We monitored 11 COVID-19 patients with ARDS for their immune phenotype, plasma cytokines, and clinical parameters on the day of ICU admission and on day 4 and day 7 of their ICU stay. Whole blood stimulation assays with lipopolysaccharide (LPS), heat-killed Listeria monocytogenes (HKLM), Aspergillus fumigatus, and Candida albicans were used to mimic secondary infections, and changes in immune phenotype and cytokine release were assessed. COVID-19 patients displayed an immune phenotype characterized by increased HLA-DR+CD38+ and PD-1+ CD4+ and CD8+ T cells, and elevated CD8+CD244+ lymphocytes, compared to healthy controls. Monocyte activation markers and cytokines IL-6, IL-8, TNF, IL-10, and sIL2Rα were elevated, corresponding to monocyte activation syndrome, while IL-1β levels were low. LPS, HKLM and Aspergillus fumigatus antigen stimulation provoked an immune response that did not differ between COVID-19 patients and healthy controls, while COVID-19 patients showed an attenuated monocyte CD80 upregulation and abrogated release of IL-6, TNF, IL-1α, and IL-1β toward Candida albicans. This study adds further detail to the characterization of the immune response in critically ill COVID-19 patients and hints at an increased susceptibility for Candida albicans infection.

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Section: T Cell and Monocyte Phenotypes And Plasma Cytokines In Seversupporting

confidence: 84%

COVID-19 Impairs Immune Response to Candida albicans

Moser¹,

Biere²,

Han³

et al. 2021

Front. Immunol.

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“…The results are shown in Figure S11. CD27 expression was upregulated in T cells cocultured with MEL526 in anionic MDP D 2 compared to T cells cocultured with A375 in anionic MDP D 2 , demonstrating increased antigen-mediated T cell activation for cells cocultured with MEL526 . The expression of CD107a on the T cells cocultured with MEL526 in D 2 was also elevated compared to cells cocultured with A375.…”

Section: Results and Discussionmentioning

confidence: 90%

“…CD27 expression was upregulated in T cells cocultured with MEL526 in anionic MDP D 2 compared to T cells cocultured with A375 in anionic MDP D 2 , demonstrating increased antigen-mediated T cell activation for cells cocultured with MEL526. 64 The expression of CD107a on the T cells cocultured with MEL526 in D 2 was also elevated compared to cells cocultured with A375. CD107a is another marker that indicates T cell activation in the cocultured CTLs and is also known to protect cytotoxic lymphocytes from damage during degranulation, explaining the maintenance of CTL viability in the hydrogels.…”

Section: Quantification Of Immune Synapses In 3dmentioning

confidence: 92%

Nanofibrous MultiDomain Peptide Hydrogels Provide T Cells a 3D, Cytocompatible Environment for Cell Expansion and Antigen-Specific Killing

Leyva-Aranda,

Singh,

Telesforo

et al. 2024

ACS Biomater. Sci. Eng.

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T cells have the ability to recognize and kill specific target cells, giving therapies based on their potential for treating infection, diabetes, cancer, and other diseases. However, the advancement of T cell-based treatments has been hindered by difficulties in their ex vivo activation and expansion, the number of cells required for sustained in vivo levels, and preferential localization following systemic delivery. Biomaterials may help to overcome many of these challenges by providing a combined means of proliferation, antigen presentation, and cell localization upon delivery. In this work, we studied self-assembling Multidomain Peptides (MDPs) as scaffolds for T cell culture, activation, and expansion. We evaluated the effect of different MDP chemistries on their biocompatibility with T cells and the maintenance of antigen specificity for T cells cultured in the hydrogels. We also examined the potential application of MDPs as scaffolds for T cell activation and expansion and the effect of MDP encapsulation on T cell phenotype. We found high cell viability when T cells were encapsulated in noncationic MDPs, O 5 and D 2 , and superior retention of antigen specificity and tumor-reactivity were preserved in the anionic MDP, D 2 . Maintenance of antigen recognition by T cells in D 2 hydrogels was confirmed by quantifying immune synapses of T Cells engaged with antigen-presenting cancer cells. When 3D cultured in anionic MDP D 2 coloaded with anti-CD3, anti-CD28, IL2, IL7, and IL15, we observed successful T cell proliferation evidenced by upregulation of CD27 and CD107a. This study is the first to investigate the potential of self-assembling peptide-based hydrogels as 3D scaffolds for human T cell applications and demonstrates that MDP hydrogels are a viable platform for enabling T cell in vitro activation, expansion, and maintenance of antigen specificity and therefore a promising tool for future T cell-based therapies.

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“…The inducible co-stimulator (ICOS or CD278) is a CD28 homolog, expressed by TCR-activated CD4 + T cells [46]. ICOS ligand [ICOSL, B7-homolog 2 (H2)] is expressed on APCs, upregulated in inflammation, and doesn't bind CD28 or CTLA-4 [47].…”

Section: Inducible Co-stimulator Ligandmentioning

confidence: 99%

Dendritic cell and co-stimulatory molecule targeted therapy for autoimmune diseases: a review of the newly implemented strategies

Jamal,

Shibli

2024

Explor Immunol

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Dendritic cells (DCs) play an important role in the formation of the immune response, and they are involved in the pathogenesis of autoimmune diseases. Targeting DCs has thus emerged as a new therapeutic modality in the management of inflammatory and autoimmune diseases. DCs can be manipulated ex vivo and then injected back into humans to suppress the immune response. They can also be manipulated in vivo by delivering specific molecules into the DCs. Co-stimulatory molecules that shape DCs interaction with T cells can also be targeted to suppress immunity. This review tackles the latest advances in each of the 3 presented approaches.

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T-Cell Costimulation and Coinhibition in Graft-Versus-Host Disease and Graft-Versus-Leukemia Effect

Cited by 3 publications

References 291 publications

COVID-19 Impairs Immune Response to Candida albicans

COVID-19 Impairs Immune Response to Candida albicans

Nanofibrous MultiDomain Peptide Hydrogels Provide T Cells a 3D, Cytocompatible Environment for Cell Expansion and Antigen-Specific Killing

Dendritic cell and co-stimulatory molecule targeted therapy for autoimmune diseases: a review of the newly implemented strategies

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